Publications by authors named "Shigeru Koba"
Background: Many patients who get discharged from the intensive care unit experience physical dysfunction that persists even after discharge. Physical dysfunction is associated with skeletal muscle atrophy and accompanying intensive care unit-acquired weakness in the early stages of intensive care unit admission, and early diagnosis and prevention with early mobilization are crucial. However, the amount of physical activity required for early mobilization remains controversial in critically ill patients.
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- The study aimed to determine the best tissue perfusion measurement for initial treatment in adults with sepsis or septic shock through a network meta-analysis.
- Researchers analyzed data from 17 randomized trials, focusing on short-term mortality within 90 days as the primary outcome.
- The findings indicated that both lactate-guided and capillary refill time-guided therapies significantly reduced short-term mortality, while central venous oxygen saturation-guided therapy was linked to increased mortality risk.
Disseminated intravascular coagulation (DIC) is a systemic life-threatening process that can cause thrombosis and hemorrhage. Chronic DIC has been associated with aortic aneurysm/dissection. Aortic aneurysm/dissection should be included in the differential diagnosis of elderly patients with hemorrhagic diathesis due to DIC of uncertain etiology.
View Article and Find Full Text PDFDiagnosis of invasive cryptococcal infection in apparently nonimmunocompromised patients is difficult and often delayed. Human immunodeficiency virus- (HIV-) negative patients with decompensated hepatic cirrhosis might be at high risk of cryptococcal infection. We report here an 82-year-old Japanese female with end-stage hepatic failure and undergoing renal dialysis, hospitalized with septic shock-like symptoms.
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- Seven elderly Japanese patients (60 - 88 years old) with vitamin B12 deficiency were studied for hemolytic anemia symptoms.
- Their serum vitamin B12 levels were significantly low, and they showed signs of thrombotic microangiopathy, which included anemia and abnormal blood test results.
- After treatment with vitamin B12, five out of the seven patients saw their anemia improve within four weeks, suggesting that vitamin B12 deficiency should be considered in similar cases of hemolytic anemia.
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- A 74-year-old Japanese woman with no prior health issues was hospitalized due to fever and high levels of C-reactive protein.
- She showed symptoms resembling Behçet’s disease, including mouth ulcers, intestinal problems, and a specific skin rash.
- During her treatment, she developed a significant increase in monocytic cells in her blood, leading to a diagnosis of acute monocytic leukemia, with the leukemic cells identified in both her skin and intestines.
In this study, we compared expression pattern of multiple microRNAs in individual patient with scleroderma with that in normal subject. Serum levels of six microRNAs (miR-7 g, miR-21, miR-29b, miR-125, miR-145 and miR-206) were evaluated using real-time PCR in 15 patients with scleroderma and 15 normal subjects. While levels of the six microRNAs were similar between the two groups, we found significant difference in the ranks between miRNAs in patients with scleroderma.
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