Publications by authors named "Shigekuni Okumura"
Cardiovasc Res
December 2024
Article Synopsis
- The study aims to understand the role of the PGE2 receptor EP4 in vascular intimal hyperplasia (IH), noting its differing effects in vascular smooth muscle cells (VSMCs) and endothelial cells.
- Researchers generated EP4 reporter mice and found that EP4 expression peaks in VSMCs two weeks post-femoral artery injury, affecting IH's progression based on EP4 levels in these cells.
- The downstream effects of EP4 signaling in VSMCs were explored, revealing that EP4 promotes VSMC proliferation and migration through fibulin-1 and its interaction with ECM1, suggesting that targeting this signaling pathway could be a potential therapeutic approach to manage IH.
