Publications by authors named "Shigeki Ohshima"
Cardiopulmonary arrest during the Nuss procedure: case report and review.
Acute Med Surg
October 2015
Article Synopsis
- * A case study highlighted a 14-year-old boy who underwent the Nuss procedure and later experienced a fatal cardiac event before the removal of the pectus bar, despite immediate bystander CPR efforts which were unsuccessful.
- * The study emphasizes the need for better management of potential emergencies related to the procedure, such as heart rhythm issues, and the importance of ongoing research for improving medical materials used in surgeries like Nuss.
Article Synopsis
- Atopic dermatitis (AD) is a common inflammatory skin condition, and recent research has focused on using a novel DNA vaccine that targets macrophage migration inhibitory factor (MIF), a protein involved in AD.
- The study tested this MIF-DNA vaccine in mouse models, finding that it not only prevented the onset of AD but also improved symptoms in mice that already had the condition.
- Results indicated that vaccinated mice showed less skin inflammation and lower levels of a specific antibody (IgE) linked to allergies, suggesting that the MIF-DNA vaccine could be a promising treatment for AD.
In this retrospective cohort study, two surgical methods of conventional open-door laminoplasty and deep extensor muscle-preserving laminoplasty were allocated for the treatment of cervical myelopathy, and were specifically compared in terms of axial pain, cervical spine function, and quality of life (QOL) with a minimum follow-up period of 2 years. Eighty-four patients were divided into two groups and received either a conventional open-door laminoplasty (CL group) or laminoplasty using a deep extensor muscle-preserving approach (MP group). The latter approach was performed by preserving multifidus and semispinalis cervicis attachments followed by open-door laminoplasty and re-suture of the bisected spinous processes at each decompression level.
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- - A retrospective study compared the surgical outcomes of correcting adolescent idiopathic scoliosis using either sublaminar Nesplon tape or sublaminar metal wire in a group of 30 patients.
- - Both groups showed similar average curve correction rates (approximately 63% for tape and 60% for wire), with no significant differences in operative time, blood loss, or patient satisfaction scores post-surgery.
- - Both methods achieved successful spinal fusion without major complications, suggesting that Nesplon tape is as effective as metal wire for treating this condition.
Article Synopsis
- The study evaluated the accuracy of pedicle screw placement in posterior scoliosis surgeries, comparing traditional methods using fluoroscopy and modern computer-assisted techniques.
- It involved a total of 45 patients, with Group C (manual control) showing a significantly higher perforation rate (11%) compared to Group N (navigation surgery) which had only 1.8%.
- The findings suggest that using a navigation system reduces insertion errors and helps avoid perforations, especially in specific vertebrae like L1 when the pedicle axis aligns closely with the sacral axis.
Objective: Previous studies have demonstrated that neutralization of macrophage migration inhibitory factor (MIF) by anti-MIF antibodies decreases joint inflammation and destruction in a type II collagen-induced arthritis model in mice. The aim of this study was to develop and describe a simple and effective method of active immunization that induces anti-MIF autoantibodies, which may neutralize MIF bioactivity.
Methods: We developed a MIF DNA vaccine by introducing oligonucleotides encoding a tetanus toxoid (TTX) Th cell epitope into the complementary DNA sequence of murine MIF.
Unlabelled: The bone phenotype of mice overexpressing MIF was studied. These mice showed decreased trabecular bone, increased bone formation rate, and increased MMP-3, -9, and -13 mRNA expression in the femora and tibias. This model provides evidence of the role played by MIF in bone remodeling and balance in vivo.
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