Publications by authors named "Shigeki Nakagawa"
Article Synopsis
- - The study examined the effect of aspirin on patients with hepatocellular carcinoma (HCC) who had liver surgery, finding that those who took aspirin showed improved outcomes compared to those who didn't.
- - Out of 1,032 patients, 87 were in the aspirin group, and results indicated significantly higher five-year recurrence-free survival (RFS) and overall survival (OS) rates for these patients.
- - The conclusion suggested that aspirin use may lead to better prognosis for HCC patients post-liver resection, highlighting the potential benefits of aspirin in this context.
Purpose: It has reported that the prevalence of frailty in patients with pancreatic cancer is 45%. The number of patients with pancreatic cancer is increasing, and within this cohort, patients often suffer from impaired activities of daily living (ADLs). This study aimed to examine the association between perioperative Barthel Index (BI) scores, a validated measure of ADLs, and survival outcomes after pancreatectomy for pancreatic cancer.
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- The study aims to assess the effectiveness and impact of minimally invasive pancreatoduodenectomy (MIPD) compared to open pancreatoduodenectomy (OPD) on patients' nutrition and immune response post-surgery.
- Out of 306 patients analyzed, MIPD showed significant benefits over OPD, including less blood loss, fewer transfusions, shorter hospital stays, and fewer complications, though it had a longer operation time.
- Despite these surgical advantages, nutritional and immunological outcomes, such as albumin levels and other indices, were similar between the two surgical methods.
Backgrounds: Several studies have indicated that BALAD score which includes the HCC tumor markers of HCC, AFP, AFP-L3%, DCP, and serum albumin and bilirubin value were good predictors of HCC patients for all treatment modalities. In this study, we aim to clarify the impact of BALAD score as the prognostic factor for HCC patients after curative surgery.
Methods: This study investigated 578 patients who underwent hepatectomy for HCC between January 2003 and May 2013.
Background: Distal pancreatectomy (DP) with lymph node (LN) dissection is the standard procedure for pancreatic ductal adenocarcinoma of the tail (Pt-PDAC). However, the optimal surgery including extent of LN dissection is still being debated. The present study investigated the incidence and prognostic impact of LN metastasis on patients suffering from Pt-PDAC.
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- - The study presents a case where molecular-targeted agents, like sorafenib, successfully treated a patient with unresectable hepatocellular carcinoma (HCC), leading to a significant reduction in tumor size and disappearance of lung metastases.
- - A 61-year-old male diagnosed with unresectable HCC underwent sorafenib treatment, which improved his condition, allowing for subsequent treatments like radiofrequency ablation (RFA) and transarterial chemoembolization (TACE).
- - After eight years, the patient remains alive and free from recurrence, indicating potential long-term survival through a combination of targeted therapy and multimodal treatments.
Aim: Patients with malignant tumors are prone to develop nutritional disorders. The Geriatric Nutritional Risk Index (GNRI) is a new prognostic indicator for assessing the nutritional status. This study was performed to evaluate whether the preoperative GNRI can serve as a prognostic factor in patients with intrahepatic cholangiocarcinoma (ICC) undergoing curative surgery.
View Article and Find Full Text PDFBackground: With the rapid aging of populations worldwide, the number of vulnerable patients with liver metastasis from colorectal cancer has increased. This study aimed to examine the association between vulnerability and clinical outcomes in patients with colorectal liver metastasis (CRLM).
Methods: Consecutive 101 patients undergoing upfront hepatectomy for CRLM between 2004 and 2020 were included.
Purpose: To investigate the prognostic impact of RAS mutations on the Japanese Society of Hepatobiliary and Pancreatic Surgeons (JSHBPS) nomogram score in patients with colorectal cancer liver metastasis (CRLM) following hepatectomy.
Methods: We included 218 consecutive patients undergoing hepatectomy for CRLM between 2004 and 2020. The JSHBPS nomogram score was calculated using six preoperative clinical factors.
Background: The number of vulnerable patients with colorectal liver metastasis (CRLM) has increased. This study aimed to clarify the relationship between perioperative activities of daily living (ADL) and clinical outcomes after hepatectomy for CRLM.
Methods: Consecutive patients undergoing resection of CRLM from 2004 to 2020 were included.
Objectives: Serine racemase (SRR) participates in serine metabolism in central nervous systems. Serine racemase is only studied in colorectal cancer, and its role in pancreatic cancer (PC) is unknown. This study aims to investigate the role of SRR in PC.
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- Statins are cholesterol-lowering drugs that inhibit HMG CoA reductase and have recently been shown to have effects on the immune system.
- In patients with resectable pancreatic cancer, statin intake was linked to better prognostic outcomes, particularly with lipophilic statins like simvastatin showing the strongest anti-proliferative effects on cancer cells.
- Simvastatin not only inhibited cancer cell growth by targeting specific protein expressions but also enhanced the effectiveness of anti-cancer immunotherapy when combined with an anti-PD-1 drug, showcasing its potential dual role in cancer treatment.
Aim: Laparoscopic and endoscopic cooperative surgery for early non-ampullary duodenum tumors (D-LECS) is now noted because of its safety and lower invasiveness. Here, we introduce two distinct approaches (antecolic and retrocolic) according to the tumor location during D-LECS.
Methods: From October 2018 to March 2022, 24 patients (25 lesions) underwent D-LECS.
Article Synopsis
- As life expectancy rises, the older population is growing, leading to a higher demand for surgeries among elderly patients with gastrointestinal cancer, who exhibit diverse health characteristics.
- The lack of specific treatment guidelines for frail older patients means they are often at risk of being either undertreated or overtreated, highlighting the importance of identifying frail individuals to improve treatment outcomes.
- Research suggests that prehabilitation, which focuses on exercise and nutrition, can enhance recovery and surgical results, and integrating geriatric assessments in clinical settings may lead to better surgical outcomes and long-term survival for these patients.
Background: Hyperglycaemia is a well-known initial symptom in patients with pancreatic ductal adenocarcinoma (PDAC). Metabolic reprogramming in cancer, described as the Warburg effect, can induce epithelial-mesenchymal transition (EMT).
Methods: The biological impact of hyperglycaemia on malignant behaviour in PDAC was examined by in vitro and in vivo experiments.
Aim: Intrahepatic cholangiocarcinoma (ICC) is a rare disease; however, its incidence and mortality are increasing worldwide. The rapid aging of populations around the world is leading to an increased number of patients with cancer who develop disability in activities of daily living (ADL). This study was conducted to investigate the associations of perioperative ADL with patient survival after hepatic resection for ICC.
View Article and Find Full Text PDFIntroduction: Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma and cancer-associated fibroblasts (CAFs) provide a favorable tumor microenvironment. Smad4 is known as tumor suppressor in several types of cancers including PDAC, and loss of Smad4 triggers accelerated cell invasiveness and metastatic potential. The thrombospondin-1 (TSP-1) can act as a major activator of latent transforming growth factor-β (TGF-β) in vivo.
View Article and Find Full Text PDFThe presence of neuroendocrine liver metastases is one of the poorest prognostic factors in patients with pancreatic neuroendocrine neoplasms, and surgical resection of neuroendocrine liver metastases is the only curable treatment. A 38-year-old man had a pancreatic neuroendocrine neoplasm with synchronous multiple liver metastases, and two surgeries and continuous everolimus and octreotide achieved R0 resection. However, multiple neuroendocrine liver metastases developed twice after more than 5 years of recurrence-free survival.
View Article and Find Full Text PDFBackground: Although PNENs generally have a better prognosis than pancreatic cancers, some PNENs display malignant behavior including lymph node (LN) metastasis. Complete tumor resection can be the only potentially curative treatment for patients with resectable PNENs. However, the indications for LN dissection are still controversial.
View Article and Find Full Text PDFBackground: The number of cancer patients with impairment of activities of daily living (ADLs) has increased. This study aimed to examine associations of perioperative Barthel index score, a validated measure of ADLs, with survival outcomes following hepatectomy for hepatocellular carcinoma (HCC).
Methods: We analyzed data of 492 consecutive patients who underwent hepatectomy for HCC between 2010 and 2018.
Prediction of hepatocellular carcinoma (HCC) risk is an urgent unmet need in patients with nonalcoholic fatty liver disease (NAFLD). In cohorts of 409 patients with NAFLD from multiple global regions, we defined and validated hepatic transcriptome and serum secretome signatures predictive of long-term HCC risk in patients with NAFLD. A 133-gene signature, prognostic liver signature (PLS)-NAFLD, predicted incident HCC over up to 15 years of longitudinal observation.
View Article and Find Full Text PDFBackground: Bloom syndrome helicase (BLM) is overexpressed in multiple types of cancers and its overexpression may induce genomic instability. This study aimed to determine the function of BLM expression in pancreatic cancer.
Methods: BLM messenger RNA (mRNA) expression was analyzed using public datasets to determine its relationship with pancreatic cancer prognosis.
Background & Aims: There is a major unmet need to assess the prognostic impact of antifibrotics in clinical trials because of the slow rate of liver fibrosis progression. We aimed to develop a surrogate biomarker to predict future fibrosis progression.
Methods: A fibrosis progression signature (FPS) was defined to predict fibrosis progression within 5 years in patients with hepatitis C virus and nonalcoholic fatty liver disease (NAFLD) with no to minimal fibrosis at baseline (n = 421) and was validated in an independent NAFLD cohort (n = 78).
Mini-abstract: The pan-immune-inflammation value was associated with clinical outcomes and tumor-infiltrating lymphocytes in 866 esophageal cancers. Systemic immune competence may influence patient prognosis through local immune response.
Objective: To examine the relationship between the pan-immune-inflammation value (PIV), tumor immunity, and clinical outcomes in 866 patients with esophageal cancer.
Article Synopsis
- Chronic liver disease and hepatocellular carcinoma (HCC) pose significant health risks with few effective treatments, largely due to the absence of suitable experimental models for research.
- The study introduces a human liver cell-based model that accurately reflects a clinical prognostic liver signature (PLS), which helps predict the progression of liver disease to HCC.
- By validating the PLS with animal models and patient samples, researchers identify nizatidine, an H2 receptor blocker, as a promising treatment for advanced liver disease and as a preventive measure against HCC, revealing new therapeutic targets through advanced analysis techniques.