Publications by authors named "Shigeki Hatanaka"
Int J Hematol
December 2024
Article Synopsis
- Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder that causes low platelet counts and can be treated with a drug called romiplostim, although data on its safety in Japan is limited.
- A 2-year survey involving 1,622 patients was conducted to assess the real-world effectiveness and safety of romiplostim, finding that 94.08% had chronic ITP and most maintained stable dosages throughout treatment.
- Results showed significant improvements in platelet counts and a favorable risk-benefit balance for romiplostim, with only a small percentage of patients discontinuing treatment due to adverse effects or improvements in their symptoms.
Open Forum Infect Dis
January 2023
Article Synopsis
- Subspecies serovar Oranienburg (SO) is typically a foodborne pathogen that rarely leads to serious infections like bacteremia; however, in 2018, 12 cases were reported in healthy individuals in southern Kyushu, Japan.
- A study using Randomly Amplified Polymorphic DNA (RAPD) analysis and whole-genome sequencing (WGS) aimed to explore the genetic similarities of the bacteremia strains and other SO isolates, revealing the bacteremia strains formed a distinct cluster.
- Findings indicate that the 12 cases resulted from a single SO clone, which may have a propensity for causing bacteremia, highlighting the need for increased surveillance on this clone and its relatives in future studies.
Clin Cancer Res
September 2004
Article Synopsis
- The study looks at how different versions of a receptor (FcgammaRIIIa) affect the way a medicine called rituximab works in fighting cancer.
- Scientists tested a new version of this medicine, called KM3065, which is made with less fucose sugar, to see if it works better than regular rituximab.
- They found that KM3065 is much more effective, working 10 to 100 times better for all donors, and even helps cells with a less effective receptor do better in fighting the disease.
