Clinical validity of proliferating cell nuclear antigen as an objective marker for evaluating biologic features in patients with untreated prostate cancer.

Background: Although Gleason grading may be the most useful system for evaluating biological activity of untreated prostate cancer, lack of interobserver validity with Gleason scores (GS) is an unsolved issue. In this study, the proliferating cell nuclear antigen labeling index (PCNA LI) in untreated prostate cancer was investigated in order to clarify the usefulness of supplemental and objective markers for evaluating the biologic features of prostate cancer.

Methods: Sixty cases of prostate cancer were randomly selected from the cancer registry in Gunma University Hospital for this study.

Arthroscopic treatment of soft-tissue impingement under the patella after total knee arthroplasty.

There has been an increased number of reports of complicated diseases of the patellofemoral joints after total knee arthroplasty (TKA). We treated soft-tissue impingement under the patella after TKA by arthroscopic surgery and investigated the findings and efficacy of the treatment. Six patients and 8 knees that showed soft-tissue impingement of patellofemoral joints after TKA were treated by arthroscopic surgery.