Signal Transducer and Activator of Transcription 3 Hyperactivation Associates With Follicular Helper T Cell Differentiation and Disease Activity in Rheumatoid Arthritis.

Follicular helper T (Tfh) cells are the specialized CD4 T cell subset that supports B cells to produce high-affinity antibodies and generate humoral memory. Not only is the function of Tfh cells instrumental to mount protect antibodies but also to support autoantibody production and promote systemic inflammation in autoimmune diseases. However, it remains unclear how the activation of Tfh cells is driven in autoimmune diseases.

Comparative analyses of phenotypic methods and 16S rRNA, khe, rpoB genes sequencing for identification of clinical isolates of Klebsiella pneumoniae.

The present work aimed to evaluate 16S rRNA, khe and rpoB gene sequencing for the identification of Klebsiella pneumoniae in comparison with phenotypic methods. Fifteen clinical isolates were examined, which were initially identified as K. pneumoniae subsp.

[An increased level of interleukin 27 in peripheral blood mononuclear cells and fibroblasts like synoviocytes of patients with rheumatoid arthritis or osteoarthritis].

Objective: To detect the levels of interleukin 27 (IL-27) and its receptor in peripheral blood mononuclear cells (PBMCs) and fibroblasts like synoviocytes (FLS) of patients with rheumatoid arthritis (RA) or osteoarthritis (OA).

Methods: PBMCs were collected from 20 patients with RA, 20 patients with OA and 20 healthy controls. FLS were cultured from synovial tissues of 4 patients with RA and 4 patients with OA.