Zoonotic Malaria: Non- Biology and Invasion Mechanisms.

Malaria, which is caused by parasites through mosquito transmission, remains one of the most life-threatening diseases affecting hundreds of millions of people worldwide every year. , which accounts for the majority of cases of recurring malaria caused by the (non-) subgenus, is an ancient and continuing zoonosis originating from monkey hosts probably outside Africa. The emergence of other zoonotic malarias (, , and ) further highlights the seriousness of the disease.

Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues .

p53 protein, activated and stabilized by posttranslational modifications, performs its major functions by inducing DNA repair, cell-cycle arrest, or apoptosis through transcriptional activation. Here, we determined the ability of p53 protein stabilized via proteasome inhibition to perform similar functions as p53 induced by stresses such as DNA damage. Treating mice with the proteasome inhibitor bortezomib stabilized p53 in stem/progenitor cells of the intestine and stomach, in other proliferating tissues, and in intestinal tumors.