A novel easily available near-infrared fluorescent probe for rapid and specific detection of Au(Ⅲ) ion in environmental water samples and its biological imaging applications in living cells and zebrafish.

The in-situ tracking of Au contaminant in the environment andorganisms has aroused considerable research interest. Herein, a simple colorimetric and near-infrared probe DPHB (2-3-(4-(dimethylamino)phenyl)allylidene)-6-hydroxybenzofuran-3(2H)-one) was strategically designed and readily synthesized for Au monitoring. DPHB presented a conspicuous fluorescence quenching response toward Au in nearly 100 % aqueous solution.

A Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detecting Hydrogen Sulfide in Environmental Waters, Wine Samples, and Living Systems.

Hydrogen sulfide (HS) is closely related to physiological diseases, environmental pollution, food safety, and plant growth. Herein, a new nopinone-based near-infrared fluorescent probe has been developed to detect HS with superior performance, including a large Stokes shift, low detection limit, good selectivity, and fast response time. was used to detect HS in environmental water and wine samples quantitatively.

A HClO-activated BODIPY based ratiometric fluorescent probe with dual near-infrared channels for differentiating cancerous cells from normal cells and surgical guidance of tumor resection.

Cancer (malignant tumor), a serious disease with a high mortality rate, early-stage diagnosis and treatment are very important for cancer therapy. The average concentration of reactive oxygen species (ROS) in cancer cells is ten times higher than in normal cells, and the overexpression of hypochlorous acid (HClO) is closely associated with cancer progression. Herein, a novel near-infrared (NIR) Golgi apparatus-targetable (GA) fluorescent probe GA-BOD-S was synthesized using the BODIPY and phenothiazine as the basic fluorescence framework for HClO monitoring.

Construction of a flavonol-based colorimetric and fluorescent probe with large Stokes shift for detecting hypochlorous acid in foodstuffs and imaging in living cells, zebrafish and plants tissues.

The excessive addition of hypochlorous acid (HClO) during food preservation can reduce the nutritional value of foodstuffs, and its abnormal levels in organisms will affect normal physiological and pathological activities. Herein, an efficient fluorescent probe HTTPC for monitoring HClO in foodstuffs and biosystems has been developed from natural flavonol. HTTPC itself emitted intense orange fluorescence emission in nearly 100 % aqueous solution, and it underwent a remarkable fluorescence quenching effect after being treated with HClO.

A near-infrared ratiometric fluorescent probe for simultaneous detection of hydrazine and hypochlorous acid in biological systems and its portable detection in environmental samples using a smartphone.

Hydrazine (NH) and hypochlorous acid (HClO) are significant chemicals that gain widespread applications in industrial fields. Excessive NH and HClO can cause severe environmental pollution and have toxic effects on living organisms. In this study, a near-infrared (NIR) dual-responsive fluorescent probe PTZ-BA was designed for the ratiometric detection of NH and HClO.

Utilization of Stable and Efficient High-Entropy (NiZnMgCuCo)AlO Catalyst with Polyvalent Transition Metals to Boost Peroxymonosulfate Activation toward Pollutant Degradation.

A polyacrylamide gel method has been used to synthesize a variety of polyvalent-transition-metal-doped Ni position of high entropy spinel oxides (NiZnMgCuCo)AlO-800 °C (A) on the basis of NiAlO, and the catalytic activity of A is studied under the synergistic action of peroxymonosulfate (PMS) activation and simulated sunlight. The A containing polyvalent transition metals (Ni, Cu, and Co) can effectively activate PMS and efficiently degrade levofloxacin (LEV) and tetracycline hydrochloride (TCH) under simulated sunlight irradiation. After 90 min of light exposure, the degradation percentages of LEV (50 mg L) and TCH (100 mg L) degrade by the A/PMS/vis system reach 87.

A novel carbazole-pyrimidine-based dual mode fluorescent probe for detection of acidic and basic pH in biological systems.

pH balance is an important factor in regulating the internal environment of body and maintaining the normal physiological activities, but pH cannot be detected in vivo without damaging the tissue. It is important to develop a pH probe with low toxicity, high sensitivity and targeting of organelles. In this research, a novel carbazole-pyrimidine-based probe PKZP was designed from 2-hydroxyl-3-pinanone which was derived from natural monoterpene α-pinene for detecting both acidic and basic pH in vivo.

A novel BODIPY-derived colorimetric and ratiometric dual-mode fluorescent probe for highly sensitive and visual detection of sulfite in food and living organisms.

Sulfite, widely used as a food additive, performs indispensable functions in the field of food sterilization, bleaching, and antisepsis. However, the overuse of sulfite may destroy food nutrition and pose health risks to people. In this work, an innovative BODIPY-based fluorescent probe (BODIPY-DBC) was constructed for highly sensitive recognition of sulfite.

Carbazole-pyrimidine-based novel ratiometric fluorescent probe with large Stokes shift for detection of hydrazine in real environments and organisms.

Widespread application of hydrazine results in serious harm on the natural environments and human health because of its highly toxic, mutagenic, carcinogenic and teratogenic properties. Hence, it is very emergent to develop a convenient and efficient method for detection of hydrazine existed in real environments and living organisms. In this work, a novel ratiometric fluorescent probe PKZ-IN from the natural monoterpenoid 2-hydroxy-3-pinanone was designed and synthesized to detect trace hydrazine.

Design, synthesis, and evaluation of a pyrazole-based corrosion inhibitor: a computational and experimental study.

By employing a synergistic blend of experimental and theoretical methodologies, we investigated the corrosion inhibition efficacy of a synthesized pyrazole derivative (BM-01) in a solution of hydrochloric acid (1 M). We utilized molecular dynamics (MD) simulations, scanning electron microscopy (SEM), density functional theory (DFT), complexation, plus electrochemical impedance spectroscopy (EIS). We conducted weight loss (WL) measurements from 298 to 328 K.

Synthesis of a new camphor-derived carboxylesterase-activated fluorescent probe for sensitive detection of dimethoate residues in agricultural products and its applications in biological systems.

In this paper, a camphor-derived enzyme activatable probe CPA was synthesized for detecting dimethoate pesticide. The ester bond of probe CPA could be selectively hydrolyzed and fragmented in the presence of carboxylesterase (CE), which caused a remarkably enhanced green fluorescence signal at 501 nm. Probe CPA could function as an effective fluorescent platform for the sequential detection of dimethoate due to the obvious inhibition effect of dimethoate on the activity of CE.

A novel fluorescent probe for fast detection of sulfur dioxide derivatives in water, soil, food samples and its applications in biological imaging.

Sulfur dioxide (SO) has a wide range of applications in food additives and industrial production, and it is one of the main substances that form acid rain, causing serious harm to ecosystems and human health. Hence, it is necessary to construct an effective tool to quickly and accurately detect SO derivatives in environmental, food, and biological samples. In this study, fluorescent probe NPMQ was built to detect SO derivatives from nopinone with the merits of superior water solubility, high sensitivity (12 nM), excellent specificity, large Stokes shift (180 nm), and rapid response time (within 5 s).

A highly effective curcumin-based fluorescent probe with single-wavelength excitation for simultaneous detection and bioimaging of Cys, Hcy and GSH.

Cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) act as significant roles in many physiological processes, and their abnormal proliferation will cause multiple diseases including Alzheimer's disease, Parkinson's disease, Cardiovascular disease, atherosclerosis, and soft tissue damage. However, It is challenging work to develop a efficient method for differentiating and detecting GSH, Cys and Hcy because of their significant similarity in structures and functions. In this work, a smart fluorescent probe FBCN based on curcumin was rationally devised and developed by etherifying the phenol hydroxyl group on FBC with NBD-Cl, which emitted strong green at 516 nm.

Rational design of a highly effective cellulose-based macromolecular fluorescent probe for real-time recognition of palladium ion in environmental samples and its applications in plant and zebrafish.

Palladium ion (Pd) plays an important role in our daily life, but poses a great threat to the environment and human health. Thus, it is desirable to exploit a rapid and sensitive approach to realize the detection of Pd. In this study, a cellulose acetate-based macromolecular fluorescent probe CA-NA-PA was successfully prepared for tracking amounts of Pd.

A ratiometric fluorescent probe with a large Stokes shift for rapid and sensitive detection of Hg in environmental water samples and its applications in living cells and zebrafish.

Detection of highly toxic mercury ions (Hg) in actual environmental and biological samples is of significant importance for protecting environment and human health. In this paper, a new ratiometric fluorescent probe BTIA was designed and synthesized from 3-pinone based on Internal Charge Transfer (ICT) mechanism. BTIA could selectively recognize Hg over other competitive analytes with short reaction time (5 s), distinct ratiometric response, strong anti-interference ability, large Stokes shift (200 nm), and low detection limit (2.

In-situ evaluation the fluctuation of hypochlorous acid in acute liver injury mice models with a mitochondria-targeted NIR ratiometric fluorescent probe.

Acute liver injury (ALI) is a frequent and devastating liver disease that has been made more prevalent by the excessive use of chemicals, drugs, and alcohol in modern life. Hypochlorous acid (HClO), an important biomarker of oxidative stress originating mainly from the mitochondria, has been shown to be intimately connected to the development and course of ALI. Herein, a novel BODIPY-based NIR ratiometric fluorescent probe Mito-BS was constructed for the specific recognition of mitochondrial HClO.

Comprehensive investigations of four ratiometric fluorescent chemosensors based on 4-(1H-imidazol-2-yl)benzaldehyde skeleton for malononitrile detection.

Malononitrile is a very important chemical material and has wide application fields in production of medicines, pesticides, and extraction of gold. However, its nonnegligible hypertoxicity inspired researchers to develop more efficient analysis techniques to sensitively and selectively detect malononitrile. Nopinone derivatives initiated by our research group have been developed as a class of organic fluorescent chemosensors for identifying multiple analytes in recent years.

A ratiometric fluorescent probe with a large Stokes shift for the detection of Hg2+ and its applications in environmental sample and living system analysis.

Toxic mercury ions (Hg2+) can cause serious environmental pollution and accumulate in living organisms the food chain. Therefore, monitoring Hg2+ is crucial in ensuring the safety of ecosystems and organisms. In this work, a novel ratiometric fluorescent probe CMT (5-(4-(diphenylamino)phenyl)-1-(7-hydroxy-coumarin-3-yl)-4-pentene-1,3-dione) based on coumarin was developed for detecting Hg2+, which displayed obvious fluorescence changes, a low detection limit (2.

Phyto-fabricated ZnO nanoparticles for anticancer, photo-antimicrobial effect on carbapenem-resistant/sensitive Pseudomonas aeruginosa and removal of tetracycline.

Alternanthera sessilis (AS) leaf extract was used to synthesize zinc oxide nanoparticles (ZnO NPs). Bioanalytical characterization techniques such as X-ray diffraction (XRD) and field emission scanning electron microscope (FESEM) confirmed the formation of crystalline ZnO NPs with average sizes of 40 nm. The AS-ZnO NPs antimicrobial activity was analyzed under dark (D) and white light (WL) conditions.

ADME Study, Molecular Docking, Elucidating the Selectivities and the Mechanism of [4 + 2] Cycloaddition Reaction Between (E)-N ((dimethylamino)methylene)benzothioamide and (S)-3-acryloyl-4-phenyloxazolidin-2-one.

The molecular electron density theory (MEDT) was employed to examine the [4 + 2] cycloaddition reaction between (E)-N-((dimethylamino)methylene)benzothioamide (1) and (S)-3-acryloyl-4-phenyloxazolidin-2-one (2) at the B3LYP/6-311++G(d,p) design level. Parr functions and energy studies clearly show that this reaction is regio- and stereoselective, in perfect agreement with experimental results. By evaluating the chemical mechanism in terms of bond evolution theory (BET) and electron localization function (ELF), which divulges a variety of variations in the electron density along the reaction path, a single-step mechanism with highly asynchronous transition states structures was revealed.

Rational design and comparison of three curcumin-based fluorescent probes for viscosity detection in living cells and zebrafish.

Viscosity is a crucial indicator of the cellular microenvironment, which can affect the normal level of cellular metabolism. Aberrant levels of viscosity can result in the emergence of a variety of physiological problems including diabetes, Parkinson's disease, inflammation, . Therefore, it is crucial to exploit effective assays that can detect viscosity levels in living cells and organisms.

Enhanced O/N separation by QuaternizedMatrimid/Multiwalled carbon nanotube mixed-matrix membrane.

The air separation (O/N) based on polymeric membranes is critical because it is more energy efficient than traditional methods. Dense polymeric membranes are now the main stay of industrial processes that generate oxygen and nitrogen enriched gas. Though, regular polymeric membranes often fall short of selective pressure demands because O and N gases have such comparable equivalent diameters.

Nano spinel NiAlO: structure, optical and photocatalytic performance evaluation and optimization.

Four kinds of spinel NiAlOwere synthesized by the polyacrylamide gel method using Al(SO)·18HO and Al(NO)·9HO as aluminum salts and anhydrous NiSOand NiSO·6HO as nickel salts. The effects of different aluminum salts and nickel salts on the structure, optical and photocatalytic activity of spinel NiAlOwere confirmed by various characterizations. There is no NiO impurity in the spinel NiAlOsynthesized with Al(SO)·18HO as aluminum salt, while NiAlO, NiO and C-O functional group coexist in the target product with Al(NO)·9HO as aluminum salt, and C-O functional group and NiO inhibits the photocatalytic activity of the system.