Causal Relationship Between the Abuse of Cholesterol-Lowering Medication, Blood Pressure Medication, Insulin, and Exogenous Hormones and Cerebral Infarction.

Background: Cholesterol-lowering medications, blood pressure medication, insulin, and exogenous hormones (including hormone replacement therapy, oral contraceptives, and minipills) are commonly utilized in clinical practice. Recent studies indicate that the use of these medications may significantly influence the occurrence and progression of cerebral infarction. This study aims to investigate the relationship between these medications and cerebral infarction using Mendelian randomization (MR) analysis, with the goal of offering valuable insights for the clinical management of cerebral infarction.

Causal Relationship between Parkinson's Disease with Heart and Vascular Disease: A Two-Sample Mendelian Randomization Study.

Introduction: The aim of this study was to investigate the causal relationship between Parkinson's disease (PD) and myocardial infarction (MI), atrial fibrillation and flutter (AF), and venous thromboembolism (VTE) by Mendelian randomization (MR) analysis.

Methods: By using data from publicly available genome-wide association studies from databases, single nucleotide polymorphisms were screened as instrumental variables, and the MR analysis was finished by inverse-variance weighted (IVW), MR-egger, weighted median methods.

Results: The primary IVW method showed a negative association between genetically predicted PD and risk of MI (OR = 0.

Application Effect of Sevoflurane Combined with Nerve Block Anesthesia in Surgical Anesthesia in Patients with Uterine Fibroids.

Sevoflurane has been widely used clinically as an inhalation anesthetic. A review of domestic and domestic research, combined with the current synthesis research, pharmacological progress, existing production capacity, production, and sales status, can show that sevoflurane is a very good new type of inhalation anesthetic. .