Publications by authors named "Shideh Mirhadi"
Article Synopsis
- Brain metastases (BMs) are the most common and lethal brain tumors, primarily originating from lung adenocarcinoma (LUAD), yet reliable predictors for their development are currently lacking.
- Researchers analyzed 402 tumor and plasma samples from LUAD patients to create a predictive model based on DNA methylation signatures, combining it with clinical data for personalized risk assessments of developing BMs.
- The study also identified unique genetic markers and immune cell changes that could aid in early detection of BMs through non-invasive tests, enhancing the potential for targeted and effective treatments.
Article Synopsis
- Nonautoimmune hyperthyroidism (NAH) results from mutations in the thyroid stimulating hormone receptor (TSHR) and correlates with a high incidence of papillary thyroid cancer in specific mouse models.
- Whole exome sequencing and phosphoproteome analysis of these mice revealed three mutated genes but indicated distinct changes in signaling pathways related to cancer development, particularly in the ERK/MAPK pathway.
- The study establishes a potential mechanism linking TSH signaling to thyroid cancer via alterations in phosphoproteins, marking a significant finding in understanding thyroid carcinoma development.
Unlabelled: The ability of a patient tumor to engraft an immunodeficient mouse is the strongest known independent indicator of poor prognosis in early-stage non-small cell lung cancer (NSCLC). Analysis of primary NSCLC proteomes revealed low-level expression of mitochondrial aconitase (ACO2) in the more aggressive, engrafting tumors. Knockdown of ACO2 protein expression transformed immortalized lung epithelial cells, whereas upregulation of ACO2 in transformed NSCLC cells inhibited cell proliferation in vitro and tumor growth in vivo.
View Article and Find Full Text PDFDiffuse midline gliomas (DMGs) bearing driver mutations of histone 3 lysine 27 (H3K27M) are incurable brain tumors with unique epigenomes. Here, we generated a syngeneic H3K27M mouse model to study the amino acid metabolic dependencies of these tumors. H3K27M mutant cells were highly dependent on methionine.
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- Non-small cell lung cancer (NSCLC) is a major cause of cancer deaths around the world, and scientists need better ways to develop targeted treatments for it.
- Researchers created 137 models from patients with NSCLC to study the disease more closely and understand its different forms based on proteins, not just DNA.
- The study found that by examining proteins, they could classify NSCLC types and find potential new treatments, making these models really useful for future cancer research.
Serine hydroxymethyltransferase 2 (SHMT2) converts serine plus tetrahydrofolate (THF) into glycine plus methylene-THF and is upregulated at the protein level in lung and other cancers. In order to better understand the role of SHMT2 in cancer a model system of HeLa cells engineered for inducible over-expression or knock-down of SHMT2 was characterized for cell proliferation and changes in metabolites and proteome as a function of SHMT2. Ectopic over-expression of SHMT2 increased cell proliferation in vitro and tumor growth in vivo.
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