Multifunctional Composite Scaffold with Nanosilver, Graphene Oxide, and Macrophage Membrane Vesicles for Sequential Treatment of Infected Bone Defects.

The management of infected bone defects poses a significant clinical challenge, and current treatment modalities exhibit various limitations. This study focuses on the development of a multifunctional composite scaffold comprising nanohydroxyapatite/polyethyleneglycol diacrylate matrix, silver nanoparticles, graphene oxide (GO), sodium alginate, and M2-type macrophage membrane vesicles (MVs) to enhance the healing of infected bone defects. The composite scaffold demonstrates several key features: first, it releases sufficient quantities of silver ions to effectively eliminate bacteria; second, the controlled release of MVs leads to a notable increase in M2-type macrophages, thereby significantly mitigating the inflammatory response.

LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs.

The differentiation fate of bone marrow mesenchymal stem cells (BMSCs) affects the progression of steroid-induced osteonecrosis of the femoral head (SONFH). We find that lncRNA DGCR5 encodes a 102-amino acid polypeptide, RIP (Rac1 inactivated peptide), which promotes the adipogenic differentiation of BMSCs and aggravates the progression of SONFH. RIP, instead of lncRNA DGCR5, binds to the N-terminal motif of RAC1, and inactivates the RAC1/PAK1 cascade, resulting in decreased Ser675 phosphorylation of β-catenin.

Stannate-Based Materials as Anodes in Lithium-Ion and Sodium-Ion Batteries: A Review.

Binary metal oxide stannate (MSnO; M = Zn, Mn, Co, etc.) structures, with their high theoretical capacity, superior lithium storage mechanism and suitable operating voltage, as well as their dual suitability for lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs), are strong candidates for next-generation anode materials. However, the capacity deterioration caused by the severe volume expansion problem during the insertion/extraction of lithium or sodium ions during cycling of MSnO-based anode materials is difficult to avoid, which greatly affects their practical applications.

Comprehensive and high-resolution emission inventory of atmospheric pollutants for the northernmost cities agglomeration of Harbin-Changchun, China: Implications for local atmospheric environment management.

Using a bottom-up estimation method, a comprehensive, high-resolution emission inventory of gaseous and particulate atmospheric pollutants for multiple anthropogenic sectors with typical local sources has been developed for the Harbin-Changchun city agglomeration (HCA). The annual emissions for CO, NOx, SO, NH, VOC, PM, PM, BC and OC during 2017 in the HCA were estimated to be 5.82 Tg, 0.

Chemical Composition and Source Apportionment of Wintertime Airborne PM in Changchun, Northeastern China.

This study presents field observations and laboratory analyses of wintertime airborne particulate matter (PM) and its chemical components in the Changchun metropolitan area, the geographical center of northeastern China. Twenty-four hour PM filter samples were collected from 23 December 2011 to 31 January 2012 at four sites in the types of traffic, residential, campus, and a near-city rural village, respectively. Daily PM concentrations ranged from 49 to 466 µg m, with an arithmetic average of 143 µg m.

[Effect of Biomass Burning on the Light Absorption Properties of Water Soluble Organic Carbon in Atmospheric Particulate Matter in Changchun].

To investigate the effect of biomass burning in Changchun in autumn on the absorbance of water-soluble organic carbon (WSOC) on PM, PM samples were collected from October to November 2017. The light absorption characteristics of WSOC, carbonaceous components, and carbohydrate content in PM were analyzed. The study showed that the average concentrations of WSOC, organic carbon (OC), and elemental carbon (EC) in PM in Changchun were (10.

[Research progress and ecological roles of phytoplankton cysts].

Phytoplankton have a complex life-cycle. Resting cysts are formed like terrestrial plants. Cysts play important roles in resisting environmental pressure, surviving adverse environment, maintaining physiological homeostasis, and maintaining species reproduction.

[Molecular Composition and Source Apportionment of Fine Organic Aerosols in Autumn in Changchun].

Organic aerosols have attracted increasing attention recently due to their significant contribution to fine particles (PM) and their complex components and sources. In this study, a total of 40 PM samples were collected simultaneously with high-volume samplers in Changchun from 16 Oct to 29 Nov 2016. Organic carbon (OC), elemental carbon (EC), non-polar organic compounds including -alkanes, polycyclic aromatic hydrocarbons (PAHs), and hopanes, and levoglucosan in atmospheric fine particles were analyzed.

[Spatial and Temporal Characteristics of Air Quality and Cause Analysis of Heavy Pollution in Northeast China].

Northeastern China experiences severe atmospheric pollution, with an increasing occurrence of heavy haze episodes. Based on ground monitoring data, satellite products and meteorological products of atmospheric pollutants in northeast China from 2013 to 2017, the characteristics of spatial and temporal distribution of air quality and the causes of heavy haze events in northeast China were discussed. It was found that the "Shenyang-Changchun-Harbin" city belt was the most polluted area in the region on an annual scale.

An in situ simultaneous measurement system combining photoelasticity and caustics methods for blast-induced dynamic fracture.

Photoelasticity and caustics methods are extensively used in the history of dynamic fracture mechanics. However, there is little work for the combination of them in the same experiment associated with high loading rate in extreme conditions. In the present work, it is the first time to build a simultaneous measurement system which can use photoelasticity and caustics methods at the same instant for in situ optical investigations of blast-induced dynamic fracture.

Chemical characteristics of dicarboxylic acids and related organic compounds in PM2.5 during biomass-burning and non-biomass-burning seasons at a rural site of Northeast China.

Fine particulate matter (PM2.5) samples were collected using a high-volume air sampler and pre-combusted quartz filters during May 2013 to January 2014 at a background rural site (4735 N, 13331 E) in Sanjiang Plain, Northeast China. A homologous series of dicarboxylic acids (C-C) and related compounds (oxoacids, α-dicarbonyls and fatty acids) were analyzed by using a gas chromatography (GC) and GC-MS method employing a dibutyl ester derivatization technique.

Local PM and PM emission inventories from agricultural tillage and harvest in northeastern China.

Mineral particles or particulate matters (PMs) emitted during agricultural activities are major recurring sources of atmospheric aerosol loading. However, precise PM inventory from agricultural tillage and harvest in agricultural regions is challenged by infrequent local emission factor (EF) measurements. To understand PM emissions from these practices in northeastern China, we measured EFs of PM and PM from three field operations (i.

Typical atmospheric haze during crop harvest season in northeastern China: A case in the Changchun region.

This study presents the mass concentrations of PM, O, SO and NO at one urban, one suburban and two rural locations in the Changchun region from September 25 to October 27 2013. Major chemical components of PM at the four sites were daily sampled and analyzed. Most of daily concentrations of SO (7-82μg/m), O (27-171μg/m) and NO (14-213μg/m) were below the limits of the National Ambient Air Quality Standard (NAAQS) in China.

Neuroprotection of Cilostazol against ischemia/reperfusion-induced cognitive deficits through inhibiting JNK3/caspase-3 by enhancing Akt1.

Cilostazol(CTL) is a phosphodiesterase inhibitor, which has been widely used as anti-platelet agent. It also has preventive effects on various central nervous system (CNS) diseases, including ischemic stroke, Parkinson's disease and Alzheimer disease. However, the molecular mechanism underlying the protective effects of CTL is still unclear, and whether CTL can prevent I/R induced cognitive deficit has not been reported.

Temporal variability of atmospheric particulate matter and chemical composition during a growing season at an agricultural site in northeastern China.

This study presents the observations of PM10 and PM2.5 concentrations at an agricultural site from April to October 2012 in Dehui city, China. Ambient air was sampled by filter-based samplers and online PM monitors.

Inorganic markers, carbonaceous components and stable carbon isotope from biomass burning aerosols in Northeast China.

To better characterize the chemical compositions and sources of fine particulate matter (i.e. PM) in Sanjiang Plain, Northeast China, total carbon (TC), organic carbon (OC), elemental carbon (EC), water-soluble organic carbon (WSOC), and inorganic ions as well as stable carbon isotopic composition (δC) were measured in this study.

The complete mitochondrial genome of the Fossorochromis rostratus.

The Fossorochromis rostratus is a species of cichlid endemic to Lake Malawi in East Africa. In this study, we first reported the complete mitochondrial genome of F. rostratus.

[Purification of the wastewater of quartz processing by mineral-based porous granulation material].

A mineral-based porous granulation material (MPGM) was prepared for absorbing the heavy metal ions from quartz processing wastewater. Analytic results of the MPGM were illustrated by the techniques of BET, SEM and FT-IR, which revealed the excellent properties of multi-aperture distribution, large specific surface area, low loss ratio and so on; the N2 adsorption-desorption isotherm was type-III with H4 hysteresis loop; the functional groups were dominated by groups of layer silicate mineral. A batch adsorption study was carried out with varied adsorbent dosage, initial pH and reaction time.

HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.

Although recent studies have found that HO-1 plays an important role in neuronal survival, little is known about the precise mechanisms occurring during cerebral ischemia/reperfusion (I/R). Therefore, the aim of this study was to investigate the neuroprotective mechanisms of HO-1 against ischemic brain injury induced by cerebral I/R and to explore whether the BDNF-TrkB-PI3K/Akt signaling pathway contributed to the protection provided by HO-1. Over-expressed HO-1 plasmids were employed to induce the overexpression of HO-1 through hippocampi CA1 injection 5 days before the cerebral I/R animal model was induced by four-vessel occlusion for 15 min transient ischemia and followed by reperfusion in Sprague-Dawley rats.

CXCR-7 receptor promotes SDF-1α-induced migration of bone marrow mesenchymal stem cells in the transient cerebral ischemia/reperfusion rat hippocampus.

The stromal cell-derived factor 1/C-X-C chemokine receptor type 4 (SDF-1/CXCR-4) axis plays an important role during stem cell recruitment. SDF-1 can also bind the more recently described CXCR-7 receptor, but effects of SDF-1/CXCR-7 signaling on stem cell migrating to ischemic brain injury area are little known. In the present study, we investigated the effect of CXCR-7 on bone marrow mesenchymal stem cell (BMSC) migration toward SDF-1α in the cerebral ischemia/reperfusion (I/R) rat hippocampus.