Management of Low-Grade Gliomas.

The term "low-grade glioma" historically refers to adult diffuse gliomas that exhibit a less aggressive course than the more common high-grade gliomas. In the current molecular era, "low-grade" refers to World Health Organization central nervous system grade 2 gliomas almost always with an isocitrate dehydrogenase (IDH) mutation (astrocytomas and oligodendrogliomas). The term "lower-grade gliomas" has emerged encompassing grades 2 and 3 IDH-mutant astrocytomas and oligodendrogliomas, to acknowledge that histological grade is not as important a prognostic factor as molecular features, and distinguishing them from grade 4 glioblastomas, which lack an IDH mutation.

Rapid detection assays for Bacillus anthracis, Yersinia pestis, and Brucella spp. via triplex-recombinase polymerase amplification.

Background: Bacillus anthracis (B. anthracis), Yersinia pestis (Y. pestis), and Brucella spp.

Radiomics for prediction of perineural invasion in colorectal cancer: a systematic review and meta-analysis.

Background: Perineural invasion (PNI) in colorectal cancer (CRC) is a significant prognostic factor associated with poor outcomes. Radiomics, which involves extracting quantitative features from medical imaging, has emerged as a potential tool for predicting PNI. This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of radiomics models in predicting PNI in CRC.

Enhanced accuracy and stability in automated intra-pancreatic fat deposition monitoring of type 2 diabetes mellitus using Dixon MRI and deep learning.

Purpose: Intra-pancreatic fat deposition (IPFD) is closely associated with the onset and progression of type 2 diabetes mellitus (T2DM). We aimed to develop an accurate and automated method for assessing IPFD on multi-echo Dixon MRI.

Materials And Methods: In this retrospective study, 534 patients from two centers who underwent upper abdomen MRI and completed multi-echo and double-echo Dixon MRI were included.

Autophagy-mediated TET2 degradation by ALV-J Env protein suppresses innate immune activation to promote viral replication.

Unlabelled: Avian leukosis virus subgroup J (ALV-J) poses a significant threat to the poultry industry; yet, our understanding of its replication and pathogenic mechanisms is limited. The Ten-Eleven Translocation 2 (TET2) is an indispensable regulatory factor in active DNA demethylation and immune response regulation. This study reports a significant and time-dependent decrease in TET2 levels following ALV-J infection and shows that the reduction of TET2 protein is mediated by the autophagy pathway.

Multifunctional Artificial Peroxisome Basing on Lactate Oxidase as a Self-Cascade Enhancing Active Oxygen Amplifier for Tumor Therapy.

The intricacy, diversity, and heterogeneity of cancers make research focus on developing multimodal synergistic therapy strategies. Herein, an oxygen (O) self-feeding peroxisomal lactate oxidase (LOX)-based LOX-Ce6-Mn (LCM) was synthesized using a biomineralization approach, which was used for cascade chemodynamic therapy (CDT)/photodynamic therapy (PDT) combination therapies through dual depletion of lactate (Lac) and reactive oxygen species (ROS) generation. After endocytosis into tumor cells, the endogenous hydrogen peroxide (HO) can be converted to O by the catalase-like (CAT) activity of LCM, which can facilitate the catalytic reaction of LOX to consume more Lac and alleviate tumor hypoxia to enhance the generation of singlet oxygen (O) upon light irradiation.

Correction: Single glucose molecule transport process revealed by force tracing and molecular dynamics simulations.

Correction for 'Single glucose molecule transport process revealed by force tracing and molecular dynamics simulations' by Yangang Pan , , 2018, , 517-524, https://doi.org/10.1039/C8NH00056E.

Fe-Catalyzed Hydrocyclization of Inactivated Alkenes to Synthesize Ring-Fused 2,3-Dihydroquinazolinone.

A Fe-catalyzed hydrocyclization reaction of unactivated alkenes was developed, utilizing PhSiH as the hydrogen source, yielding 2,3-dihydroquinazolinone (DHQZ) derivatives in moderate to good yields. Notably, when the substrate was switched to -cyano--(2-(prop-1-en-2-yl)phenyl)benzamides, the reaction yielded only the unreduced products. Mechanistic studies revealed that the intramolecular addition of the in situ formed radical to the unactivated alkene results in the formation of the fused ring.

Single Cell-Pair Proteomics for Decoding Immune-Cancer Cell Interactions.

The efficacy of cancer immunotherapy is significantly influenced by the heterogeneity of individual tumors and immune responses. To investigate this phenomenon, a microfluidic platform is constructed for profiling immune-cancer cell interactions at the single-cell proteomics level for the first time. Based on the platform, a comprehensive workflow is proposed for achieving accurate single-cell pairing of an immune cell and a cancer cell with low cell damage and high success rate up to 95%, cell pair co-culture, and real-time microscopic monitoring of the cell-pair interactions, cell pair retrieval, mass spectrometry-based proteomic analysis of singe cell pairs, and decoupling of the proteomic information for each cell within the cell pair with the stable-isotope labeling method.

Nanodrugs Targeting Key Factors of Ferroptosis Regulation for Enhanced Treatment of Osteoarthritis.

Osteoarthritis (OA) is a globally prevalent degenerative joint disease. Recent studies highlight the role of ferroptosis in OA progression. Targeting ferroptosis regulation presents a promising therapeutic strategy for OA; however, current research primarily focuses on single targets associated with ferroptosis.

Advances on Defect Engineering of Niobium Pentoxide for Electrochemical Energy Storage.

The reasonable design of advanced anode materials for electrochemical energy storage (EES) devices is crucial in expediting the progress of renewable energy technologies. NbO has attracted increasing research attention as an anode candidate. Defect engineering is regarded as a feasible approach to modulate the local atomic configurations within NbO.

In Situ Anchoring Functional Molecules to Polymer Chains Through Supramolecular Interactions for a Robust and Self-Healing Multifunctional Waterborne Polyurethane.

Nowadays, much attention is paid to the development of high-performance and multifunctional materials, but it is still a great challenge to obtain polymer materials with high mechanical properties, high self-healing properties, and multifunctionality in one. Herein, an innovative strategy is proposed to obtain a satisfactory waterborne polyurethane (PMWPU-Bx) by in situ anchoring 3-aminophenylboronic acid (3-APBA) in a pyrene-capped waterborne polyurethane (PMWPU) via supramolecular interactions. The multiple functional sites inherent in 3-APBA can produce supramolecular interactions with groups on PMWPU, promoting the aggregation of hard domains in the polymer network, which confers the PMWPU-Bx strength (7.

2D Perovskite Heterojunction-Based Self-Powered Polarized Photodetectors with Controllable Polarization Ratio Enabled by Ferro-Pyro-Phototronic Effect.

Metal halide perovskites (MHPs) are commonly used in polarization-sensitive photodetectors (PDs) for applications such as polarization imaging, remote sensing, and optical communication. Although various methods exist to adjust the polarization-sensitive photocurrent, a universal and effective approach for continuous control of MHPs' optoelectronic and polarized properties is lacking. A universal strategy to electrically modulate the polarization ratio (PR) of self-powered polarized PDs using the ferro-pyro-phototronic effect (FPPE) in 2D perovskites is presented.

Cerebral tissue oxygen saturation and its potential relationship with neurodevelopmental delay in pediatric liver transplant recipients.

Objective: To discover the potential association between diminished intraoperative average SctO levels and postoperative neurodevelopmental delays among patients after pediatric living-donor liver transplantation.

Study Design: Patients undergoing living-donor liver transplantation were recruited for this trial. The neurodevelopment status of patients was assessed using the Ages Stages Questionnaires.

Narcolepsy in early childhood: a case report and a Mini review.

Narcolepsy is a sleep-wake disorder with an onset commonly seen in individuals aged 10-30 years. Due to various reasons, the diagnosis of narcolepsy often experiences a delay of at least ten years. Diagnosing narcolepsy in children is particularly challenging due to atypical symptoms, leading to frequent misdiagnosis or missed diagnoses.

Hemostatic effect of oxidized regenerated cellulose vs. topical tranexamic acid in total knee arthroplasty-a prospective randomized controlled trial.

Aims: This study compared the hemostatic effects and complications of oxidized regenerated cellulose (ORC) and topical TXA in total knee arthroplasty (TKA), thus providing a reference for the use of ORC as an alternative hemostatic agent to TXA in TKA.

Methods: A total of 105 patients were included in this study and randomized into blank control, ORC, and TXA groups. The primary outcomes were total blood loss, hemoglobin drop (Hb drop), transfusion rates, and incidence of thrombosis.

Polydatin retards the progression of osteoarthritis by maintaining bone metabolicbalance and inhibiting macrophage polarization.

Background: Polydatin (PD), also known as tiger cane glycoside, is a natural compound extracted from the Japanese knotweed plant, which is often referred to as white resveratrol. It exhibits anti-inflammatory, antioxidant, and anti-apoptotic effects in the treatment of various diseases. However, the potential molecular mechanisms of PD in osteoarthritis have not been clearly elucidated.

Alterations of gray matter volume and functional connectivity in patients with cognitive impairment induced by occupational aluminum exposure: a case-control study.

Background: Cognitive impairment (CI) is a condition in which an individual experiences noticeable impairment in thinking abilities. Long-term exposure to aluminum (Al) can cause CI. This study aimed to determine the relationship between CI and MRI-related changes in postroom workers exposed to Al.

Involvement of the posterior limb of the internal capsule independently predicts the prognosis of patients with basal ganglia and thalamic hemorrhage.

Background: Intracerebral hemorrhage (ICH) is the most lethal and devastating subtype of stroke. Basal ganglia hemorrhage and thalamic hemorrhage are the most common types of ICH, accounting for 50-70% of all ICH cases, leading to disability and death, and it involves the posterior limb of the internal capsule to varying degrees. In this study, we investigated the impact of varying degrees of the involvement of the posterior limb of the internal capsule on the prognosis of patients with basal ganglia and thalamic ICH and assessed whether it improves the predictive accuracy of the max-ICH score, an existing scale for ICH functional outcome.

A case report of hypospadias combined with polyorchidism.

Hypospadias is a common congenital malformation of the reproductive system; however, to date, no cases of hypospadias complicated by polyorchidism have been reported in the literature. This article reports a case of a 1-year-old boy presenting with hypospadias, who was also diagnosed with polyorchidism combined with cryptorchidism. Preoperative Doppler ultrasound revealed two testes on the right side, and an atrophic testis on the left.

Application of artificial intelligence in the health management of chronic disease: bibliometric analysis.

Background: With the rising global burden of chronic diseases, traditional health management models are encountering significant challenges. The integration of artificial intelligence (AI) into chronic disease management has enhanced patient care efficiency, optimized treatment strategies, and reduced healthcare costs, providing innovative solutions in this field. However, current research remains fragmented and lacks systematic, comprehensive analysis.

Impact of preoperative blood glucose levels on prognosis and postoperative complications in patients with pancreatic cancer.

The relationship between diabetes and pancreatic cancer is well documented; however, the effect of preoperative blood glucose levels on prognosis and postoperative complications is currently unclear. The present study aimed to investigate the effect of preoperative blood glucose levels on overall survival (OS) and postoperative complications in patients with pancreatic cancer. This retrospective study included 225 patients with pancreatic cancer treated at The Fourth Hospital of Hebei Medical University from January 2015 to December 2020.

Analysis of Factors Related to Pulmonary Nodules in Patients With Fatty Liver: A Large-Scale Cohort Study Based on a Physical Examination Population.

Purpose: People with fatty liver are at high risk for pulmonary nodules, but the underlying mechanism is unclear. This study aimed to investigate the occurrence of lung nodules in fatty liver patients and explore influencing factors.

Patients And Methods: We retrospectively analyzed 57,119 individuals who underwent health checkups at the People's Hospital of Guangxi from May 2020 to May 2024.

Isolation, identification and characteristics of from diseased rainbow trout ().

is an opportunistic pathogen that can infect humans, animals and aquatic species, which is widely distributed in different aquatic environments and products. In recent years, with the rapid expansion of intensive aquaculture, the disease caused by has occurred. This study aims to understand the pathogenic characteristics of and provide scientific basis for the prevention and control of the epidemic.

Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants.

Background: Antibiotics, as the most commonly prescribed class of drugs in neonatal intensive care units, have an important impact on the developing neonatal gut microbiota. Therefore, comprehending the effects of commonly used antibiotic therapy on the gut microbiota and butyrate-producers in early infants could provide information for therapeutic decision-making in the NICU.

Objectives: To explore the effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants.