The drug risks of cilostazol: A pharmacovigilance study of FDA Adverse Event Reporting System database.

Objective: Cilostazol is indicated for alleviating intermittent claudication (IC) in stable-phase peripheral arterial disease (PAD) patients. Conducting data mining on adverse events (AEs) of cilostazol in the U.S.

Evaluation of the immobilized enzymes function in soil remediation following polycyclic aromatic hydrocarbon contamination.

The bioremediation of polycyclic aromatic hydrocarbon (PAHs) from soil utilizing microorganisms, enzymes, microbial consortiums, strains, etc. has attracted a lot of interest due to the environmentally friendly, and cost-effective features. Enzymes can efficiently break down PAHs in soil by hydroxylating the benzene ring, breaking the C-C bond, and catalyze the hydroxylation of a variety of benzene ring compounds via single-electron transfer oxidation.

Synergistic approach of GCW-ISTR for enhanced remediation of semi-volatile organic contaminants in groundwater: Modeling and experimental validation.

The poor remediation performance of groundwater circulation well (GCW) on semi-volatile organic contaminants (such as aniline) has severely limited its practical application. To address the challenges posed by the low volatility and solubility of these contaminants, an innovative integration of GCW with in-situ thermal remediation (ISTR) was proposed to create a thermal enhanced circulation well (GCW-ISTR) in this study. Laboratory experiments and model simulations were performed to evaluate the heat transfer and enhanced remediation effect by GCW-ISTR.

Bibliometric analysis and systematic review of electrochemical methods for environmental remediation.

Electrochemical methods are increasingly favored for remediating polluted environments due to their environmental compatibility and reagent-saving features. However, a comprehensive understanding of recent progress, mechanisms, and trends in these methods is currently lacking. Web of Science (WoS) databases were utilized for searching the primary data to understand the knowledge structure and research trends of publications on electrochemical methods and to unveil certain hotspots and future trends of electrochemical methods research.

A new method of alkalinity remediation for Cd-contaminated groundwater by PAAS-modified MgCO/Mg(OH) colloid.

Mg(OH) dissolves slowly and can provide a long-term source of alkalinity, thus a promising alternative reagent for the in situ remediation of heavy metal polluted groundwater. Unfortunately, it exhibits a relatively poor stabilization effect on heavy metal Cd due to the higher solubility of the resulting stabilized product, Cd(OH). To overcome this limitation, we investigated the use of MgCO/Mg(OH) colloid modified by sodium polyacrylate (PAAS) to remove Cd from groundwater.

Light Addressable Potentiometric Sensors for Biochemical Imaging on Microscale: A Review on Optimization of Imaging Speed and Spatial Resolution.

Light addressable potentiometric sensors (LAPS) are a competitive tool for unmarked biochemical imaging, especially imaging on microscale. It is essential to optimize the imaging speed and spatial resolution of LAPS since the imaging targets of LAPS, such as cell, microfluidic channel, etc., require LAPS to image at the micrometer level, and a fast enough imaging speed is a prerequisite for the dynamic process involved in biochemical imaging.

"Wane and wax" strategy: Enhanced evolution kinetics of liquid phase LiS to LiS via mutually embedded CNT sponge/Ni-porous carbon electrocatalysts.

The lithium-sulfur battery (Li-S) has been considered a promising energy storage system, however, in the practical application of Li-S batteries, considerable challenges remain. One challenge is the low kinetics involved in the conversion of LiS to LiS. Here, we reveal that highly dispersed Ni nanoparticles play a unique role in the reduction of LiS.

A Simulation Optimization Factor of Si(111)-Based AlGaN/GaN Epitaxy for High Frequency and Low-Voltage-Control High Electron Mobility Transistor Application.

The effects of barrier layer thickness, Al component of barrier layer, and passivation layer thickness of high-resistance Si (111)-based AlGaN/GaN heterojunction epitaxy on the knee-point voltage (), saturation current density (), and cut-off frequency () of its high electron mobility transistor (HEMT) are simulated and analyzed. A novel optimization factor is proposed by considering the various performance parameters of the device to reduce the and improve the on the premise of ensuring the . Based on this factor, the optimized AlGaN/GaN epitaxial structure was designed with a barrier layer thickness of 20 nm, an Al component in the barrier layer of 25%, and a SiN passivation layer of 6 nm.

Light addressable potentiometric sensor with well-ordered pyramidal pits-patterned silicon.

Light addressable potentiometric sensor (LAPS) with the structure of electrolyte-insulator-semiconductor is a kind of field effect sensor that detects local potential changes caused by protonation and deprotonation between electrolyte and insulator by light pulse. And scanned light pulse allows two-dimensional imaging of the distribution of chemical/biological species on the surface of sensor. An important challenge is to achieve low-cost, strong anti-interference and high-performance silicon-based LAPS.

Molecular Simulation of Methane Adsorption Capacity of Matrix Components of Shale.

Shale gas occurs mainly as adsorption and free gas. Among them, whether the adsorbed gas can be gradually desorbed or not is a major cause of stable and high yield. The matrix component is the main factor affecting the adsorption capacity of shale.

Microbial functional changes mark irreversible course of Tibetan grassland degradation.

The Tibetan Plateau's Kobresia pastures store 2.5% of the world's soil organic carbon (SOC). Climate change and overgrazing render their topsoils vulnerable to degradation, with SOC stocks declining by 42% and nitrogen (N) by 33% at severely degraded sites.

Electrodeposition of cobalt-iron bimetal phosphide on Ni foam as a bifunctional electrocatalyst for efficient overall water splitting.

To solve environmental pollution and energy crisis, it is essential to design an efficient, economical, and stable bifunctional electrocatalyst for water splitting to produce renewable energy sources H and O. In this study, low-crystallinity and microspherical CoFe-P/NF catalyst synthesized by potentiostat electrodeposition on a foam nickel substrate had an excellent hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and water splitting performance. In 1 M KOH solution, the CoFe-P/NF required the overpotentials of 45 mV for HER and 287 mV for OER in order to create a current density of 10 mA cm.

Light-Addressable Potentiometric Sensors in Microfluidics.

The light-addressable potentiometric sensor (LAPS) is an electrochemical sensor based on the field-effect principle of semiconductors. It is able to sense the change of Nernst potential on the sensor surface, and the measuring area can be controlled by the illumination of a movable light. Due to the unique light-addressable ability of the LAPS, the chemical imaging system constructed with the LAPS can realize the two-dimensional image distribution detection of chemical/biomass.

Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4).

Diabetic nephropathy (DN) is associated with inflammation. Platycodin D (PD) demonstrates anti-inflammatory activity. However, whether PD affects DN remains to be explored.

Nutrients in the rhizosphere: A meta-analysis of content, availability, and influencing factors.

Nutrient deficiency in most terrestrial ecosystems constrains global primary productivity. Rhizosphere nutrient availability directly regulates plant growth and is influenced by many factors, including soil properties, plant characteristics and climate. A quantitatively comprehensive understanding of the role of these factors in modulating rhizosphere nutrient availability remains largely unknown.

Impact of ZnO nanoparticles on soil lead bioavailability and microbial properties.

In the present study, we investigated the responses of microbial respiration and community structure, enzyme activity and DTPA-extractable Pb within 60 days of incubation in soils treated with Pb and nano-ZnO. The results showed that when the concentration of nano-ZnO exceeded 10 mg/kg, the concentration of DTPA-extractable Pb significantly decreased by 10.6%-21.

Copper and Zirconium Codoped O3-Type Sodium Iron and Manganese Oxide as the Cobalt/Nickel-Free High-Capacity and Air-Stable Cathode for Sodium-Ion Batteries.

Considering the abundance of iron and manganese within the Earth's crust, the cathode O3-NaFeMnO has shown great potential for large-scale energy storage. Following the strategy of introducing specific heteroelements to optimize the structural stability for energy storage, the work has obtained an O3-type NaFeMnCuZrO that exhibits enhanced electrochemical performance and air stability. It displays an initial reversible capacity of 147.

Honeycomb meshed working electrodes based on microsphere lithography for high-resolution chemical image sensor.

The chemical image sensor has attracted much attention because of its ability to visualize the spatial distribution of biochemical species in solution. However, the lateral diffusion of photo-generated carriers generated by illuminating backside of the substrate limits the spatial resolution of the sensor and the sharpness of the image. In this study, honeycomb meshed metal array based on microsphere lithography as working electrodes of the sensor is proposed.

The critical role of titanium cation in the enhanced performance of P2-NaNiMnTiO cathode material for sodium-ion batteries.

Tremendous effort has been devoted to develop durable electrode materials for sodium ion batteries. This work focuses on enhancing the reversibility of a cathode material NaNiMnO by adopting the titanium cation doping strategy. The obtained P2-NaNiMnTiO material shows smooth charge-discharge curves upon suppressing the Na/vacancy ordering effect via the partial substitution of Mn for Ti, and enhanced cycling performance.

Impact of manure on soil biochemical properties: A global synthesis.

Manure application mitigates land degradation and improves soil fertility. Despite many individual studies on manure effects, a comprehensive overview of its consequences for a broad range of soil properties is lacking. Through a meta-analysis of 521 observations spanning the experiments from days after pulse addition up to 113 years with continues manure input, we quantified and generalized the average responses of soil biochemical properties depending on climate factors, management, soil, and manure characteristics.

Hub Proteins Involved in RAW 264.7 Macrophages Exposed to Direct Current Electric Field.

At present, studies on macrophage proteins mainly focus on biological stimuli, with less attention paid to the responses of macrophage proteins to physical stimuli, such as electric fields. Here, we exploited the electric field-sensitive hub proteins of macrophages. RAW 264.

Cellular processes involved in lung cancer cells exposed to direct current electric field.

With the rapid breakthrough of electrochemical treatment of tumors, electric field (EF)-sensitive genes, previously rarely exploited, have become an emerging field recently. Here, we reported our work for the identification of EF-sensitive genes in lung cancer cells. The gene expression profile (GSE33845), in which the human lung cancer CL1-0 cells were treated with a direct current electric field (dcEF) (300 mV/mm) for 2 h, was retrieved from GEO database.

Low-Strain Reticular Sodium Manganese Oxide as an Ultrastable Cathode for Sodium-Ion Batteries.

Sodium-ion batteries (SIBs) are recognized as attractive alternatives for grid-scale electrochemical energy storage applications. Transition metal oxide cathodes represent one of the most dynamic materials for industrialization among the various cathodes for SIBs. Here, a cation-doped cathode NaMnTiO with a tunnel structure is introduced, which undergoes a lowered volume change of only 5.

Microplastics in aquatic environments: Toxicity to trigger ecological consequences.

The prevalence of microplastic debris in aquatic ecosystems as a result of anthropogenic activity has received worldwide attention. Although extensive research has reported ubiquitous and directly adverse effects on organisms, only a few published studies have proposed the long-term ecological consequences. The research in this field still lacks a systematic overview of the toxic effects of microplastics and a coherent understanding of the potential ecological consequences.

Synergistic construction of green tea biochar supported nZVI for immobilization of lead in soil: A mechanistic investigation.

Biochar-based nanocomposites with functional materials provide an excellent prospect in reactivity and stability. Most biochar reported have no reusability upon aging and offer the risk of release of immobilized components after short-term immobilization. To overcome this, we developed nano zero-valent iron (nZVI) impregnated magnetic green tea biochar (nZVI@GTBC) and studied its performance in immobilizing Pb and long-term effectiveness in the soil.