Photocatalytic degradation of norfloxacin antibiotics on ZnCdS/g-CN composites in water.

g-CN/ZnCdS composites were synthesized by a simple hydrothermal method. The composites were characterized by X-ray diffraction, UV-vis diffuse reflectance spectroscopy, infrared spectroscopy, and electron micro-projective microscopy. According to the performance of ZnCdS for the photocatalytic degradation of norfloxacin under visible light in water, the best stoichiometric number of x was 0.

Prevalence, early predictors, and outcomes of sepsis in neurocritical illnesses: A prospective cohort study.

Background: Patients with neurocritically illness are an under-recognized population at high risk of sepsis. We aimed to investigate the prevalence, early predictors, and outcomes of sepsis in neuro-ICU.

Methods: Daily and accumulative incidences of sepsis in neuro-ICU were explored.

Prevalence, predictors, and outcomes of acute respiratory distress syndrome in severe stroke.

Objectives: Patients with severe stroke are at high risk of developing acute respiratory distress syndrome (ARDS), but this severe complication was often under-diagnosed and rarely explored in stroke patients. We aimed to investigate the prevalence, early predictors, and outcomes of ARDS in severe stroke.

Methods: This prospective study included consecutive patients admitted to neurological intensive care unit (neuro-ICU) with severe stroke, including acute ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage.

Blood-brain barrier damage and new onset refractory status epilepticus: An exploratory study using dynamic contrast-enhanced magnetic resonance imaging.

Objective: This study was undertaken to characterize the blood-brain barrier (BBB) dysfunction in patients with new onset refractory status epilepticus (NORSE) using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).

Methods: This study included three groups of adult participants: patients with NORSE, encephalitis patients without status epilepticus (SE), and healthy subjects. These participants were retrospectively included from a prospective DCE-MRI database of neurocritically ill patients and healthy subjects.

The clinical value of neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage.

Background: Inflammatory mechanisms play important roles in intracerebral hemorrhage (ICH) and have been linked to the development of stroke-associated pneumonia (SAP). The neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) are inflammatory indexes that influence systemic inflammatory responses after stroke. In this study, we aimed to compare the predictive value of the NLR, SII, SIRI and PLR for SAP in patients with ICH to determine their application potential in the early identification of the severity of pneumonia.

Variability across countries for brain death determination in adults.

Background: The guidelines of brain death determination vary across countries. Our aim was to compare diagnostic procedures of brain death determination in adults among five countries.

Method: Consecutive comatose patients who received brain death determination from June 2018 to June 2020 were included.

Geniposide attenuates early brain injury by inhibiting oxidative stress and neurocyte apoptosis after subarachnoid hemorrhage in rats.

Background: Oxidative stress and neurocyte apoptosis are crucial pathophysiological process in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Geniposide (GNP) has been reported to exert neuroprotective effects by reducing oxidative injury and neurocyte apoptosis. However, the effect of GNP has not been clarified in EBI after SAH.

Nutraceutical Study on , a Wild Medicinal Food Plant in Northwest Yunnan, China.

(Franch) LaFrankie (Asparagaceae), called in Tibetan or in Drung or in local Chinese, is a wild vegetable consumed by the Tibetan people and other ethnic groups in Northwest Yunnan, China. It is also a traditional medicinal plant used by different linguistic groups for antimicrobial purposes. However the nutritional and phytochemical compositions of this important medicinal food plant have not been well studied previously.

New Micropeptins with Anti-Neuroinflammatory Activity Isolated from a Cyanobacterial Bloom.

Metabolite mining of environmentally collected aquatic and marine microbiomes offers a platform for the discovery of new therapeutic lead molecules. Combining a prefractionated chromatography library with liquid chromatography tandem mass spectrometry (LC-MS/MS)-based molecular networking and biological assays, we isolated and characterized two new micropeptins ( and ) along with the previously characterized micropeptin 996. These metabolites showed potency in anti-neuroinflammatory assays using BV-2 mouse microglial cells, showing a 50% reduction in inflammation in a range from 1 to 10 μM.

Reversible leukoencephalopathy caused by 2 rodenticides bromadiolone and fluoroacetamide: A case report and literature review.

Rationale: With the easy access, rodenticide poisoning has been a public health problem in many countries. Characteristics of central nervous system (CNS) lesions induced by rodenticides are scarcely reported.

Patient Concerns: We presented a case of a 40-year-old man with seizure and consciousness disorder, coagulation dysfunction, and symmetric lesions in white matter and corpus callosum.

Refractory Status Epilepticus Responsive to Electroacupuncture at Shuigou Acupoint: A Case Report.

Refractory status epilepticus (RSE) is a critical and intractable neurological emergency. Around 55% of RSE episodes still persist despite high dose of continuous infusion of anesthetics. It's a clinical urgency and challenge to search for novel alternative treatments to control RSE as soon as possible.

Pesticide-derived bright chlorine-doped carbon dots for selective determination and intracellular imaging of Fe(III).

Inspired by the conversion from organics or biomass to fluorescent carbon dots (C-dots), the use of pesticide 4-chlorophenol (4-CP) as a precursor to prepare C-dots has been reported. The as-prepared chlorine-doped C-dots display a brightly blue emission at ∼445 nm with ∼22.8% quantum yield.

Three new compounds with nitric oxide inhibitory activity from , an ethnomedicinal plant from Southwest China.

The medicinal plant has been used by the Zhuang ethnic people in mountainous areas of Southwest China to stop bleeding, invigorate blood circulation, and treat inflammation and wounds. In order to further explore its traditional medicinal uses, the phytochemical constituents of this species were examined. Three new compounds, the lignan tirpitzin (), the flavonoid tirpitzoside (), and the furan-glycoside tirpitziol (), along with five known compounds were isolated from the aerial part of for the first time.

Jaboticabin and Related Polyphenols from Jaboticaba ( Myrciaria cauliflora) with Anti-inflammatory Activity for Chronic Obstructive Pulmonary Disease.

Myrciaria cauliflora (jaboticaba) is an edible fruit common in Brazil that has been used for treating respiratory diseases, including chronic tonsillitis and asthma. This study explores the distribution of an anti-inflammatory depside, jaboticabin, in different parts of the jaboticaba plant as well as major polyphenols from the wood of jaboticaba, some with biological activity similar to jaboticabin. The peel of the fruit was found to be the major source of jaboticabin.

Cyanobufalins: Cardioactive Toxins from Cyanobacterial Blooms.

Cyanobufalins A-C (1-3), a new series of cardiotoxic steroids, have been discovered from cyanobacterial blooms in Buckeye Lake and Grand Lake St. Marys in Ohio. Compounds 1-3 contain distinctive structural features, including geminal methyl groups at C-4, a 7,8 double bond, and a C-16 chlorine substituent that distinguish them from plant- or animal-derived congeners.

The Effect of a Scanning Strategy on the Residual Stress of 316L Steel Parts Fabricated by Selective Laser Melting (SLM).

The laser scanning strategy has an important influence on the surface quality, residual stress, and deformation of the molten metal (deformation behavior). A divisional scanning strategy is an effective means used to reduce the internal stress of the selective laser melting (SLM) metal part. In order to understand and optimize the divisional scanning strategy, three divisional scanning strategies and an S-shaped orthogonal scanning strategy are used to produce 316L steel parts in this study.

Microcystins Containing Doubly Homologated Tyrosine Residues from a Microcystis aeruginosa Bloom: Structures and Cytotoxicity.

Four new microcystin congeners are described including the first three examples of microcystins containing the rare doubly homologated tyrosine residue 2-amino-5-(4-hydroxyphenyl)pentanoic acid (Ahppa) (1-4). Large-scale harvesting and biomass processing allowed the isolation of substantial quantities of these compounds, thus enabling complete structure determination by NMR as well as cytotoxicity evaluation against selected cancer cell lines. The new Ahppa-toxins all incorporate Ahppa residues at the 2-position, and one of these also has a second Ahppa at position 4.

Customized a Ti6Al4V Bone Plate for Complex Pelvic Fracture by Selective Laser Melting.

In pelvic fracture operations, bone plate shaping is challenging and the operation time is long. To address this issue, a customized bone plate was designed and produced using selective laser melting (SLM) technology. The key steps of this study included designing the customized bone plate, metal 3D printing, vacuum heat treatment, surface post-processing, operation rehearsal, and clinical application and evaluation.

Adsorption of Cr(VI) on nano Uio-66-NH MOFs in water.

An efficient adsorbent, nano Uio-66-NH Metal-organic frameworks (MOFs), for the high efficiency removal of Cr(VI) from aqueous solution was successfully synthesized. The adsorbent was characterized and its performance in Cr(VI) removal was evaluated for the first time. Kinetic data reveal that the Cr(VI) adsorption is rapid in the beginning followed by a slower adsorption process; The Cr(VI) adsorption kinetics were well described by the pseudo-second-order kinetics model.

UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives.

A number of Garcinia species accumulate benzophenone derivatives that may be useful for the treatment of breast cancer. The dereplication of new benzophenone derivatives from Garcinia species is challenging due to the occurrence of multiple isomers and the known compounds found in their extracts. In the current study, a strategy is described using the UPLC-QTOFMS(E) technique to identify tentatively the known and uncharacterized benzophenones of interest based upon the characteristic fragmentation ions.

Development of a nanosphere adsorbent for the removal of fluoride from water.

A new uniform-sized CeCO3OH nanosphere adsorbent was developed, and tested to establish its efficiency, using kinetic and thermodynamic studies, for fluoride removal. The results demonstrated that the CeCO3OH nanospheres exhibited much high adsorption capacities for fluoride anions due to electrostatic interactions and exchange of the carbonate and hydroxyl groups on the adsorbent surface with fluoride anions. Adsorption kinetics was fitted well by the pseudo-second-order model as compared to a pseudo-first-order rate expression, and adsorption isotherm data were well described by Langmuir model with max adsorption capacity of 45mg/g at pH 7.