Publications by authors named "Shibi B Likhite"
Article Synopsis
- Neuroinflammation plays a significant role in worsening neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), but existing treatments focusing only on this inflammation have not been effective in clinical trials.
- Previous research has shown that correcting motor neurons and astrocytes improves ALS outcomes, yet mice still face mortality due to persistent inflammation, indicating a need for a more comprehensive approach.
- The study introduces a new treatment combining galectin-1 to target microglia with AAV9-mediated SOD1 suppression, resulting in reduced inflammation and improved survival rates in ALS mouse models, emphasizing the importance of addressing inflammatory microglia in future therapies.