Publications by authors named "Shibani Panda"
Rabies is a zoonotic viral disease with inevitably fatal outcome. Toll-like receptor 3 (TLR3) could sense dsRNA viral infections, and implicated in pathogenesis of rabies and Negri bodies (NBs) formation. Present study was undertaken to elucidate the role of TLR3 in pathogenesis, NBs formation, and therapeutic potential of blocking TLR3/dsRNA interaction in rabies infection.
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- Rabies is a deadly neurological infection caused by the rabies virus, affecting all warm-blooded animals and leading to over 60,000 deaths annually worldwide, with wildlife like bats and raccoons being primary carriers.
- The incubation period varies but averages 2-3 months; diagnosis is crucial and done through methods like the direct immunofluorescent test (dFAT) and PCR, with rapid diagnosis aiding in treatment and prevention.
- Vaccination strategies in endemic areas include live attenuated, inactivated, DNA, and recombinant vaccines, along with ongoing research into effective control measures and therapeutic approaches.