The Relationship between Alzheimer's Disease and Ferroptosis: A Bibliometric Study Based on Citespace.

Background: The potential relationship between Alzheimer's Disease (AD) and ferroptosis has received considerable attention, yet there is no comprehensive visualization analysis in this field. This study aimed to explore the research frontiers and hotspots through bibliometric analysis.

Methods: Literature related to AD and ferroptosis was collected from the Web of Science Core Collection.

[Lumbar disc nucleus pulposus excision by percutaneous endoscopic interlaminar approach for single segment giant lumbar disc herniation in young adults].

Objective: To explore feasibility, clinical and imaging outcomes of percutaneous endoscopic interlaminar discectomy (PEID) for single level large lumbar disc herniation(LDH).

Methods: From October 2018 to March 2023, 31 patients with single level LDH treated with PEID were retrospectively analyzed. Among patients, including 18 males and 13 females, aged from 15 to 40 years old with an average of (28.

Different types of pesticide exposure and lung cancer incidence in the Agricultural Health Study cohort: A systematic review and meta-analysis.

Lung cancer is the dominant cause of worldwide cancer mortality. The relationship between pesticide exposure and lung cancer risk has shown mixed results epidemiologically. We hypothesized this discrepancy could arise from the varying effects of different pesticides and conducted this meta-analysis by using three pesticide classification schemes to examine the implications of diverse pesticide exposure types on lung cancer risk.

Current Knowledge on Craniodental Anatomy and Dental Pathology in Golden Snub-Nosed Monkeys (Rhinopithecus roxellana): A Comparative Review.

The Sichuan golden snub-nosed monkey (Rhinopithecus roxellana) is a rare and endangered species endemic to China that occupies a particularly important position in the evolutionary history of Rhinopithecus species. Oral health is a crucial aspect of overall well-being in both humans and nonhuman primates. We review the current limited literature on the dental characteristics and dental pathologies related to the golden snub-nosed monkey, based on skeleton data and morphological evidence.

Imbalance of muscles around the cervical spine in patients with degenerative cervical spondylotic kyphosis and myelopathy.

Background: To measure the muscle strength around the cervical spine; clarify the relationships among muscles, cervical sagittal alignment, and cervical spondylotic myelopathy(CSM); and understand the process underlying loss of cervical lordosis.

Methods: Sex, age, course of illness, and radiological data were obtained for patients with CSM and a control group of healthy individuals. C2-7 Cobb angles were measured in cervical radiographs, and the vertebral body areas(VBAs) and cross-sectional areas(CSAs) of the deep flexors, superficial flexors(SF), deep extensors, and superficial extensors(SE) were measured from the C3/4 to C6/7 intervertebral levels in T2-weighted axial magnetic resonance images.

Hydrogen sulfide-mediated inhibition of ROCK exerts a vasoprotective effecton ischemic brain injury.

As a gas molecule, hydrogen sulfide (HS) exerts neuroprotective effects. Despite its recognized importance, there remains a need for a deeper understanding of HS's impact on vascular smooth muscle cells and its role in ischemic brain injury. This study employs encompassing cultured primary cerebral vascular smooth muscle cells, oxygen-glucose deprivation/reoxygenation model, in vitro vascular tone assessments, in vivo middle cerebral artery occlusion and reperfusion experimentation in male rats, and the utilization of ROCK knockout, to unravel the intricate relationship between H2S and cerebrovascular diastolic function.

Lignin nanoparticle/MXene-based conductive hydrogel with mechanical robustness and strain-sensitivity property via rapid self-gelation process towards flexible sensor.

Conductive hydrogels have been showcased with substantial potential for soft wearable devices. However, the tedious preparation process and poor trade-off among overall properties, i.e.

Glucose oxidase-driven self-accelerating drug release nanosystem based on metal-phenolic networks orchestrates tumor chemotherapy and ferroptosis-based therapy.

Nanocarriers responding to tumor microenvironment have been extensively exploited to improve the antitumor outcome of chemotherapeutic drugs. However, selectively and completely releasing drugs within the tumor remains a challenge, thereby limiting the therapeutic effect of drug delivery nanosystem. To tackle this challenge, a metal-phenolic networks (MPNs)-based nanosystem (F-MGD) showing the capability of self-accelerating drug release was originally fabricated in this study.

Comparison of conventional diffusion-weighted imaging and multiplexed sensitivity-encoding combined with deep learning-based reconstruction in breast magnetic resonance imaging.

Purpose: To evaluate the feasibility of multiplexed sensitivity-encoding (MUSE) with deep learning-based reconstruction (DLR) for breast imaging in comparison with conventional diffusion-weighted imaging (DWI) and MUSE alone.

Methods: This study was conducted using conventional single-shot DWI and MUSE data of female participants who underwent breast magnetic resonance imaging (MRI) from June to December 2023. The k-space data in MUSE were reconstructed using both conventional reconstruction and DLR.

Multiomics analysis reveals aberrant tryptophan-kynurenine metabolism and immunity linked gut microbiota with cognitive impairment in major depressive disorder.

Objective: Cognitive impairment occurs throughout the entire course of and affects the work and life of patients with major depressive disorder (MDD). The gut microbiota, kynurenine pathway (KP) and inflammatory response may have important roles in the mechanism of cognitive impairment in MDD patients. Consequently, our goal was to investigate the association among the gut microbiota, inflammation, KP, and cognition in MDD.

Novel insights into the circ_0003489/let-7b-5p/GLUT1 axis and its possible role in multiple myeloma.

Background: Circular RNAs (circRNAs) act as vital players in multiple myeloma (MM). Herein, we focused on the function of hsa_circ_0003489 (circ_0003489) in MM development and bortezomib (BTZ) resistance.

Methods: Relative RNA levels were detected by quantitative real-time polymerase chain reaction (qRT-PCR).

Hyperoside ameliorates neuropathic pain by modulating the astroglial reactivity in the vlPAG.

Hyperoside, a natural flavonoid, exhibits a wide range of biological activities, including analgesic effects on acute and chronic inflammatory pain. This study illustrates that repeated intraperitoneal administration or microinjection of hyperoside into the ventrolateral periaqueductal grey (vlPAG) alleviated mechanical allodynia, cold allodynia, and abnormal gait induced by spared nerve injury (SNI) in male mice. Furthermore, repeated hyperoside administration suppressed SNI-induced astrocyte reactivity in the vlPAG.

Assessment of the Variability and Correlation of Biometric Measurements in Eyes with Cataracts.

Purpose: To assess the variability and correlation of ocular biometric parameters in eyes with cataracts and examine their association with age and gender.

Methods: A retrospective analysis was performed on biometric data from 7,458 eyes without retinal pathologies, using an optical biometer equipped with low-coherence reflectometry technology. Pearson's correlation coefficients (r) were used to evaluate the relationships between age, gender, and various ocular parameters, including axial length (AL), anterior chamber depth (ACD), lens thickness (LT), central corneal thickness (CCT), corneal refractive power (Km), and white-to-white (WTW) measurement.

Comparison of thrombopoietin receptor agonists plus recombinant human thrombopoietin vs. recombinant human thrombopoietin alone for hematopoietic reconstruction in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation.

Background: Hetrombopag is a novel thrombopoietin receptor agonist that has shown an additive effect in stimulating platelet production when combined with recombinant human thrombopoietin (rhTPO). But it remains unclear whether this combination can promote hematopoietic reconstruction after autologous stem cell transplant (ASCT).

Purpose: To compare the effect of recombinant human thrombopoietin (rhTPO) plus thrombopoietin receptor agonists (TPO-RA) versus rhTPO alone on hematopoietic recovery, adverse events, post-operative complications, and cost effectiveness in patients with newly diagnosed multiple myeloma (NDMM) undergoing autologous stem cell transplant (ASCT).

Blockade of PVN neuromedin B receptor alleviates inflammation via the RAS/ROS/NF-κB pathway in spontaneously hypertensive rats.

Neuromedin B (NMB) has potentially great impacts on the development of cardiovascular diseases by promoting hypertensive and sympatho-excitation effects. However, studies regarding the NMB function in paraventricular nucleus (PVN) are lacking. With selective neuromedin B receptor (NMBR) antagonist, BIM-23127, we aim to determine whether the blockade of NMB function in PVN could alleviate central inflammation and attenuate hypertensive responses.

The Application of Quantum Dots in Dental and Oral Medicine: A Scoping Review.

Objectives: To present an overview of quantum dots' (QDs) applications in dental and oral medicine, identify research gaps in existing relevant research, and provide insights into future research.

Data And Sources: An extensive electronic search was conducted across five databases from their inception to April 2024, complemented by a manual search. There were no restrictions regarding language or publication year.

Vermicomposting significantly reduced antibiotic resistance genes in cow manure even under high tetracycline concentrations.

Minimizing antibiotic resistance genes (ARGs) in livestock manure is crucial for curbing ARG dissemination. Vermicomposting can eliminate ARGs, but the effect of residual antibiotics on its reduction efficacy remains unclear. Herein, Eisenia foetida was employed to convert cow manure with varying concentrations of tetracycline (i.

Trends, characteristics, and circumstances surrounding stimulant toxicity deaths in Ontario, Canada from 2018 to 2021.

Introduction: As the drug toxicity crisis continues to evolve globally, harms related to non-opioid substances, including stimulants, have risen in parallel. Our study aims were to describe trends in accidental stimulant toxicity deaths and to characterize demographic characteristics of decedents and the circumstances surrounding death.

Methods: We conducted a population-based repeated cross-sectional study, of all accidental stimulant toxicity deaths between January 1, 2018, and December 31, 2021, in Ontario, Canada.

Identification and comparative genomic analysis of endophytic fungi in Bletilla striata and its potential for promoting militarine bioaccumulation.

Bletilla striata (Thunb.) Reichb.f is renowned for its traditional medicinal applications and a spectrum of pharmacological activities, which is intricately linked to militarine.

DNAJC12 downregulation induces neuroblastoma progression via increased histone H4K5 lactylation.

Neuroblastoma (NB) is the most common extracranial solid tumor in children. Despite treatment advances, the survival rates of high-risk NB patients remain low. This highlights the urgent need for a deeper understanding of the molecular mechanisms driving NB progression to support the development of new therapeutic strategies.

Single-step genome-wide association study reveals candidate genes for body mass index trait in Yunong-black pigs.

Body mass index (BMI) can serve as a reasonable indicator of overall body fat content in pigs. This study aimed to identify underlying variants and candidate genes associated with BMI in Yunong-black pigs. A single-step genome-wide association analysis (GWAS) was performed on 1405 BMI records and 924 Yunong-black pigs genotyped using a 50 K SNP Chip.

Coordination-Defect-Driven Construction of Responsive Pure-MOF Microspheres for Switchable Mode-Dependent Anticounterfeiting Labels.

Luminescent metal-organic frameworks (MOFs) with exceptional dynamics and diverse active sites possess tremendous potential in information security and anticounterfeiting applications. However, traditional MOF systems are based on broadband spectral signals with spectrum overlap, which easily leads to low-resolution signal identification, compromising the overall security level. Here, we report the coordination-defect-induced amorphous pure-MOF microsphere with switchable whispering-gallery-mode (WGM) signals as a mode-dependent security platform.

Reconfigurable Phototransistors Driven by Gate-Dependent Carrier Modulation in WSe/TaNiSe van der Waals Heterojunctions.

Reconfigurable field-effect transistors (RFETs) offer notable benefits on electronic and optoelectronic logic circuits, surpassing the integration, flexibility, and cost-efficiency of conventional complementary metal-oxide semiconductor transistors. The low on/off current ratio of these transistors remains a considerable impediment in the practical application of RFETs. To overcome these limitations, a van der Waals heterojunction (vdWH) transistor composed of WSe/TaNiSe has been proposed.

A Spatial Registration Method Based on Point Cloud and Deep Learning for Augmented Reality Neurosurgical Navigation.

Background: In order to achieve spatial registration for surgical navigation, a spatial registration method based on point cloud and deep learning is proposed.

Methods: Neural networks are used to register medical image point clouds and patient surface point clouds to complete spatial registration of surgical navigation. An image processing method is designed to convert medical images into point clouds, and a structured light robot is used to extract patient surface point clouds.