Publications by authors named "Shiau-Chi Chen"
Intracellular trafficking, an extremely complex network, dynamically orchestrates nearly all cellular activities. A versatile method that enables the manipulation of target transport pathways with high spatiotemporal accuracy in vitro and in vivo is required to study how this network coordinates its functions. Here, a new method called RIVET (Rapid Immobilization of target Vesicles on Engaged Tracks) is presented.
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- Microtubules play a critical role in regulating various cellular functions, but traditional methods to study them are slow and insufficient for understanding specific microtubule types.
- The study introduces a new technique using chemo and optogenetics to quickly disassemble targeted microtubule subtypes, allowing for real-time observation of their effects on cellular processes.
- Findings reveal that rapid microtubule disruption affects vesicular trafficking, organelle organization, mitochondrial dynamics, and cell rigidity, while preventing cell division without inducing cell death during interphase.