Publications by authors named "Shiaowen David Hsu"
Article Synopsis
- Patients with unresectable colorectal liver metastases often undergo systemic chemotherapy to make their condition operable, but many do not achieve this after first-line treatment.
- Despite limited success with second- and third-line therapies, there’s renewed interest in combining hepatic artery infusion chemotherapy with systemic treatments as a way to improve outcomes.
- Recent studies show promising results for this combined approach, even among patients who are resistant to traditional chemotherapy, leading to wider adoption across North America and beyond.
Background: Hepatic artery infusion (HAI) is a liver-directed therapy that delivers high-dose chemotherapy to the liver through the hepatic arterial system for colorectal liver metastases and intrahepatic cholangiocarcinoma. Utilization of HAI is rapidly expanding worldwide.
Objective And Methods: This review describes the conduct of HAI pump implantation, with focus on common technical pitfalls and their associated solutions.
Despite a considerable expenditure of time and resources and significant advances in experimental models of disease, cancer research continues to suffer from extremely low success rates in translating preclinical discoveries into clinical practice. The continued failure of cancer drug development, particularly late in the course of human testing, not only impacts patient outcomes, but also drives up the cost for those therapies that do succeed. It is clear that a paradigm shift is necessary if improvements in this process are to occur.
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