Publications by authors named "Shian Chiuan Tzeng"
Background: Effective therapy for COVID-19 remains limited. Hydroxychloroquine (HCQ) has been considered, but safety and efficacy concerns remain. Chitosan exhibits antiviral and immunomodulatory effects, yet how the combination of HCQ and chitosan performs in treating COVID-19 is unknown.
View Article and Find Full Text PDFThere is an urgent need for treatments for hydrofluoric acid (HF) burns and their derivative problems that prevent hydrogen ion dissociation and fluoride ion binding to tissues. This study evaluated the ability of chitosan-based hydrogels combined with a buffer solution containing either boric acid or Tris and calcium gluconate (CHS-BA-CG and CHS-Tris-CG) to repair HF burn wounds and prevent wound infections. We assessed calcium release rates and biocompatability and constructed a mouse HF burn model to assess the tissue repair effects of the hydrogels.
View Article and Find Full Text PDFArticle Synopsis
- Tigecycline, an antibiotic, shows promise as a cancer treatment by potentially addressing chemotherapy side effects and drug resistance, but high doses necessary for effectiveness may lead to increased side effects.
- * This study tested the combination of tigecycline with pyrvinium pamoate to see if it could enhance anti-cancer effects by inhibiting cell growth and inducing cell death more effectively than either drug alone.
- * Findings suggest that this combination therapy stops cancer cell progression and enhances treatment outcomes for breast cancer by employing different mechanisms, making it a novel approach worth further exploration.
Article Synopsis
- The study presents a new microfluidic hanging-drop culture system designed with a taper-tube that improves droplet stability and enhances liquid exchange rates in cell culture.* -
- The surrounding ring structure allows for better cell seeding before fluid perfusion and minimizes mechanical stress during culture, which helps maintain stem cell phenotype.* -
- This innovative system allows for easy observation and analysis of cultured cells, positioning it as a promising platform for in vitro studies that mimic in vivo conditions, particularly for regenerative therapy.*
Applications of poly(l-lactide) (PLA) and poly(d,l-lactide-co-glycolide) (PLGA) microspheres are widely used in the biomedical and pharmaceutical fields. The effects of PLA/PLGA on microsphere properties when using conventional particulate preparation methods are not easily defined due to the uncontrollable particle size and size distribution. This study was aimed to synthesize uniform PLA and PLGA microspheres using a phenol formaldehyde resin-based microfluidic chip, which has the advantage of being solvent-resistant, flexible, and is readily disassembled for cleaning.
View Article and Find Full Text PDF