Tumor-Repopulating Cell-Derived Microparticle-Based Therapeutics Amplify the Antitumor Effect through Synergistic Inhibition of Chemoresistance and Immune Evasion.

Traditional chemotherapy often encounters failure attributed to drug resistance mediated by tumor-repopulating cells (TRCs) and chemotherapy-triggered immune suppression. The effective inhibition of TRCs and the mitigation of drug-induced immune suppression are pivotal for the successful chemotherapy. Here, TRC-derived microparticles (3D-MPs), characterized by excellent tumor-targeting and high TRC uptake properties, are utilized to deliver metformin and the chemotherapeutic drug doxorubicin ((DOX+Met)@3D-MPs).

Effect of Nitrogen Fertilizer on the Rhizosphere and Endosphere Bacterial Communities of Rice at Different Growth Stages.

This study aimed to investigate the impact of nitrogen (N) fertilizer on bacterial community composition and diversity in the rhizosphere and endosphere of rice at different growth stages. Two treatments, N0 (no N application) and N1 (270 kg N ha), were implemented, with samples collected during the jointing, tasseling, and maturity stages. High-throughput sequencing was used to analyze the structure and composition of bacterial communities associated with Huaidao No.

Probing the Effects of Multisite Mutations in the Lipoic Acid Region of the BCOADC-E2 Protein.

Primary biliary cholangitis (PBC) is a chronic disease, the prevalence of which has been increasing in recent years. And the prevalence of patients who test negative with existing diagnostic techniques remains high. It was found that the antigenic BCOADC-E2 protein could detect patients with a negative original test.

Downscaling of ERA5 reanalysis land surface temperature based on attention mechanism and Google Earth Engine.

Land Surface Temperature (LST) is widely recognized as a sensitive indicator of climate change, and it plays a significant role in ecological research. The ERA5-Land LST dataset, developed and managed by the European Centre for Medium-Range Weather Forecasts (ECMWF), is extensively used for global or regional LST studies. However, its fine-scale application is limited by its low spatial resolution.

Cognitive disorders: Potential astrocyte-based mechanism.

Cognitive disorders are a common clinical manifestation, including a deterioration in the patient's memory ability, attention, executive power, language, and other functions. The contributing factors of cognitive disorders are numerous and diverse in nature, including organic diseases and other mental disorders. Neurodegenerative diseases are a common type of organic disease related to the pathology of neuronal death and disruption of glial cell balance, ultimately accompanied with cognitive impairment.

Optimizing Cu doping on carbon nitrogen holly shell for enhanced selectivity towards formate in CO reduction.

Electrochemical carbon dioxide reduction reaction (ECORR) to produce high value-added products is a promising and effective strategy for closing the artificial carbon cycle and achieving sustainable development of resource. However, catalyst structural reorganization and agglomeration caused by the reduction process will reduce the catalytic performance. In this study, a carbon nitrogen shell with cupper-doped (CNCu shell) catalyst was prepared using silicon dioxide (SiO) as a template.

Role of Pyroptosis in IVIG-Resistant Kawasaki Disease and the Establishment of a New Predictive Model.

Background: Intravenous immunoglobulin (IVIG) resistance may be an increased risk of coronary artery lesions which is the serious complication of Kawasaki disease (KD). Early and accurate identification of IVIG-resistant patients has an important clinical value.

Objective: To establish a new predicting model by detecting the pyroptosis markers with other clinical indicators.

Action recognition in rehabilitation: combining 3D convolution and LSTM with spatiotemporal attention.

This study addresses the limitations of traditional sports rehabilitation, emphasizing the need for improved accuracy and response speed in real-time action detection and recognition in complex rehabilitation scenarios. We propose the STA-C3DL model, a deep learning framework that integrates 3D Convolutional Neural Networks (C3D), Long Short-Term Memory (LSTM) networks, and spatiotemporal attention mechanisms to capture nuanced action dynamics more precisely. Experimental results on multiple datasets, including NTU RGB + D, Smarthome Rehabilitation, UCF101, and HMDB51, show that the STA-C3DL model significantly outperforms existing methods, achieving up to 96.

Nuclear Overexpression of SAMHD1 Induces M Phase Stalling in Hepatoma Cells and Suppresses HCC Progression by Interacting with the Cohesin Complex.

Emerging evidence suggests that the sterile alpha-motif (SAM) and histidine-aspartate (HD) domain-containing protein 1 (SAMHD1) is implicated in various cancers, including hepatocellular carcinoma (HCC). However, its precise role in tumor cells and the underlying mechanisms remain unclear. This study aimed to investigate the expression patterns, prognostic values, and functional role of SAMHD1 in HCC progression.

The diagnostic value of contrast-enhanced ultrasound combined with clinicopathological features in microinvasive ductal carcinoma .

Background: Ductal carcinoma in situ with microinvasion (DCISM) represents 1% of all breast cancer cases and is arguably a more aggressive subtype of ductal carcinoma in situ (DCIS). Preoperative evaluation of DCISM usually relies on core needle biopsy, and non-invasive evaluation methods are relatively limited. This study aims to explore the features of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) in DCISM and to analyze the US and clinicopathological predictors of infiltrating components.

L3-SMI as a predictor of overall survival in oesophageal cancer patients receiving PD-1 inhibitors combined with chemotherapy.

Background: Programmed death ligand-1 (PD-1), as an immunotherapy target, has been increasingly used in tumour therapies. But as reactions and outcomes to PD-1 inhibitors combined with chemotherapy vary individually, it is primarily important to identify an ideal indicator for predicting the therapeutic effectiveness in individual patients. Oesophageal cancer (EC) patients often have difficulty eating due to tumour blockage of the oesophagus, leading to malnutrition and muscle loss.

Dynamic-Cycling Zinc Sites Promote Ruthenium Oxide for Sub-Ampere Electrochemical Water Oxidation.

Although iridium-based electrocatalysts are commonly regarded as the sole stable operating acidic oxygen evolution reaction (OER) catalysts in proton-exchange membrane water electrolysis (PEMWE) devices, their exorbitant cost and scarcity severely restrict their widespread application. Herein, we introduce a promising alternative to iridium: zinc-doped ruthenium dioxide (TE-Zn/RuO), which exhibits remarkable and enduring activity for acidic OER. characterizations elucidate that the dynamic cycling of zinc dopants serves as both electron acceptors and donors, facilitating the activation of Ru sites at low overpotentials while thwarting peroxidation at high overpotentials, thus concurrently achieving heightened activity and robust stability.

Organic food consumption is positively associated with cognitive function among middle-aged and older adults: cross-sectional and longitudinal analyses.

Purpose: Examine cross-sectional and longitudinal relationships between organic food consumption and cognitive function among older adults.

Methods: In this study, 6077 participants were selected from the 2012 Health and Retirement Study (HRS) and the Health Care and Nutrition Study (HCNS) for cross-sectional analyses, and retaining 4882 individuals for longitudinal analyses. Organic food consumption was assessed using a Food Frequency Questionnaire and participants were categorized based on their organic dietary diversity score.

Modulating the Ruthenium-Cobalt Active Pair with Moderate Spacing for Enhanced Acidic Water Oxidation.

Ruthenium (Ru)-based catalysts have emerged as promising alternatives to Iridium (Ir) catalysts in proton exchange membrane water electrolysis cells due to their lower price and excellent oxygen evolution reaction (OER) activity. However, their stability is compromised by generation of unstable high-valence Ru sites and oxygen vacancy in a lattice oxygen-mediated (LOM) pathway. Here, a low-load Ru site on a Barium (Ba)-doped CoO (RuBaCoO) catalyst is developed with abundant Ruthenium─Cobalt (Ru─Co) pairs for enhanced acidic OER activity.

A green deep eutectic solvent-based aqueous two-phase system combined with chemometrics for flavonoids extracting and detecting in honey.

In this study, an eco-friendly and designable aqueous two-phase system (ATPS) was developed using natural deep eutectic solvents (DES) and short-chain alcohols. The formation mechanism and influence of various factors on phase behavior were investigated. Optimal extraction parameters were determined through single-factor experiments and response surface methodology (RSM): 45 °C temperature, 45 % -propanol, 40 % DES, and 0.

Multi-Cohort Analysis Reveals Altered Archaea in Colorectal Cancer Fecal Samples Across Populations.

Background And Aim: Archaea are important components of the host microbiome, but their roles in colorectal cancer (CRC) remain largely unclear. We aimed to elucidate the contribution of gut archaea to CRC across multiple populations.

Methods: This study incorporated fecal metagenomic data from 10 independent cohorts from 7 countries and an additional in-house cohort, totaling 2101 metagenomes (748 CRC, 471 adenoma, and 882 healthy controls [HCs]).

A green extraction method based on aqueous two-phase system for trace-level enrichment of multi-residue pesticides in traditional Chinese medicine prior to HPLC-MS/MS quantitative analysis.

At present, the matrix interference in traditional Chinese medicine (TCM) is still a great challenge for multi-residue pesticides analysis. Herein, an alcohol/salt aqueous two-phase system (ATPS) based on n-propanol and (NH)SO was developed by comparing the binodal curve phase diagrams and the extraction rates of pesticides. The specific extraction conditions, including the composition of the ATPS, temperature, pH, and extraction time were explored through single factor experiments, and subsequently optimized using orthogonal array design and response surface methodology.

Tech vs. Tradition: ChatGPT and Mindfulness in Enhancing Older Adults' Emotional Health.

To improve older adults' mental health, this study compared the effects of AI chatbots, such as ChatGPT 3.0, with traditional mindfulness therapies on loneliness and depression in older adults. Despite interest in AI as a complementary tool, empirical evidence on its impact remains limited.

Effects of Tanreqing injection on the gut microbiota in healthy volunteers.

Objectives: Many studies have confirmed that antibacterial agents can disrupt the human gut microbiota. In China, Tanreqing injection (TRQ) is a drug with antibacterial activity that is widely used in the treatment of respiratory infections. However, its specific influence on gut microbiota remains unclear.

Multimodal Photoacoustic/Elastography Imaging for the Detection of Acute Radiation Dermatitis in Breast Radiation Therapy.

Purpose: This study aimed to evaluate whether photoacoustic (PA), sound touch elastography (STE), and viscoelasticity (VE) can distinguish between normal and abnormal postradiation therapy breast skin and compare these methods with Radiation Therapy Oncology Group (RTOG) criteria at a 20 Gy threshold.

Methods And Materials: Patients who met inclusion and exclusion criteria underwent PA, STE, and VE on the same day. Collected data included radiation dose, molecular type, RTOG, Fitzpatrick skin type, pathology, neoadjuvant chemotherapy status, TNM (tumor, node, metastasis) classification, surgical procedures, primary breast cancer location, body mass index, and age.

Crude Blueberry Phenolic Extracts Improve Gut Barrier Integrity and Exert Anti-Inflammatory and Antimicrobial Activity in an In Vitro Weaning Stress Model.

Piglet weaning is accompanied by gastrointestinal tract (GIT) dysfunction, resulting in post-weaning diarrhea (PWD). The treatment involves antibiotics due to the susceptibility of the weaned GIT to pathogens. However, antibiotic resistance has shifted attitudes toward a nutraceutical approach by enriching feed with functional compounds.