Enhancement of tunneling electroresistance in metal/two-dimensional ferroelectric tunnel junctions: route for polarization-modulated interface transport.

In fabricating ferroelectric tunnel junction (FTJ) devices, it is essential to employ low-resistance metals as electrodes interfacing with two-dimensional (2D) ferroelectric materials. For FTJs with a top contact configuration, two interfaces for charge transport are present, namely the vertical interface between the metal electrode and the 2D ferroelectric material, and the lateral interface between the electrode and the central scattering region. These interfaces significantly influence the tunneling electroresistance (TER) of FTJs.

Short- and long-term impacts of the National Essential Medicines Policy on drug availability, price, and usage in a deprived rural county in southwestern China: an interrupted time series analysis across 8 years.

Background: China's National Essential Medicines Policy (NEMP) has been implemented for over 15 years; yet empirical evidence on its long-term impacts is lacking, particularly in remote and rural regions. This study aims to assess the short-and long-term effects of NEMP on the drug availability, price, and usage in a deprived rural county in southwestern China.

Methods: A quasi-experimental design was employed, featuring a single-group pre-and-post comparison.

Reutilization of post-adsorption lanthanum-loaded straw alleviates phosphorus pollution in rice-wheat system: Subsequent performance and underlying mechanisms.

Adsorption technology for phosphorus (P) removal is considered promising and reutilization of post-adsorbent can contribute to promoting sustainable agricultural production. However, the long-lasting impact of the post-adsorbent on crop growth and P remains unclear. This study assessed the effects of P-adsorbed lanthanum-modified straw (La@straw-P) on the rice yield, P fractionation and associated water quality parameters.

A systematic review of the epidemiology of pediatric autoimmune encephalitis: disease burden and clinical decision-making.

Background: Autoimmune encephalitis (AIE) comprises a group of rare, immune system-mediated conditions. Clinical manifestations among children are not well-characterized, and there are challenges in testing and diagnosis. This can result in treatment delays, which has been found to correlate with poorer long-term outcomes.

[Effects of Straw and Fertilizer Managements on Nitrogen Loss in Rice Cultivation in Taihu Lake Basin].

Nitrogen loss from rice systems is an important source of agricultural non-point source pollution. Many studies revolve around reducing the rate of nitrogen fertilizer application. However, studies examining the characteristics of nitrogen loss in multiple loss paths （runoff, leaching, and lateral seepage） under different straw and fertilizer managements are lacking.

Efficient magnetic capture of PE microplastic from water by PEG modified FeO nanoparticles: Performance, kinetics, isotherms and influence factors.

Due to their resistance to degradation, wide distribution, easy diffusion and potential uptake by organisms, microplastics (MPs) pollution has become a major environmental concern. In this study, PEG-modified FeO magnetic nanoparticles demonstrated superior adsorption efficiency against polyethylene (PE) microspheres compared to other adsorbents (bare FeO, PEI/FeO and CA/FeO). The maximum adsorption capacity of PE was found to be 2203 mg/g by adsorption isotherm analysis.

Sustainable design of photo-Fenton-like oxidation process in actual livestock wastewater through the highly dispersed FeCl anchoring on a g-CN substrate.

Photocatalytic technology emerges as a promising solution for the sustainable treatment of contaminated wastewater. However, the practical implementation of designed photocatalysts often faces challenges due to the intricate 'high carbon footprint' process and limited outdoor laboratory investigations. Herein, a simple yet versatile impregnation approach is proposed to anchor highly dispersed FeCl on a g-CN substrate (Fe-CN) with minimal energy consumption and post-processing.

Resource diversity disturbs marine diversity and community stability, but loss of diversity enhances community stability.

is a salt-tolerant heterotrophic bacterium that occupies an important ecological niche in marine environments. However, little is known about the contribution of resource diversity to the marine diversity and community stability. In this study, we investigated the association among resource diversity, taxonomic diversity, phylogenetic diversity, and community stability of marine in the Beibu Gulf.

Strategies to reduce fishy odor in aquatic products: Focusing on formation mechanism and mitigation means.

Aquatic products, integral to human diets, often bear a distinct fishy odor that diminishes their appeal. Currently, the formation mechanisms of these odoriferous compounds are not fully understood, complicating their effective control. This review aims to provide a comprehensive overview of key fishy compounds, with a focus on their formation mechanisms and innovative methods for controlling fishy odors.

Manure derived hydrochar reduced phosphorus loss risk via an alteration of phosphorus fractions and diversified microbial community in rice paddy soil.

Phosphorus (P) loss caused by the irrational use of manure organic fertilizer has become a worldwide environmental problem, which has caused a potential threat to water safety and intensified agricultural non-point source pollution. Hydrothermal carbonization is method with a low-energy consumption and high efficiency to deal with environmental problems. Application of pig manure-derived hydrochar (PMH) to soil exhibited potential of sustainable development compared with the pristine pig manure (PM).

Leveraging collaborative research networks against antimicrobial resistance in Asia.

Background: Antimicrobial resistance (AMR) is a global health security threat requiring research collaboration globally and regionally. Despite repeated calls for international research collaboration in Asia, literature analyzing the nature of collaborative AMR research in Asia has been sparse. This study aims to describe the characteristics of the AMR research network in Asia and investigate the factors influencing collaborative tie formation between organizations.

Enhanced tunneling electroresistance through interfacial charge-modulated barrier in-InSe-based ferroelectric tunnel junction.

The manipulation of tunneling resistance is critical for ferroelectric tunnel junction (FTJ) devices. In this work, we propose a mechanism to manipulate tunneling resistance through interfacial charge-modulated barrier in two-dimensional (2D)-type semiconductor/ferroelectric FTJs. Driven by ferroelectric reversal, different effective tunneling barriers are realized by the depletion or accumulation of electrons near the-type semiconductor surface in such devices.

Photochemical behavior of dissolved organic matter derived from Alternanthera philoxeroides hydrochar: Insights from molecular transformation and photochemically reactive intermediates.

Hydrochar-derived dissolved organic matter (HDOM) enters aquatic ecosystems through soil leaching and surface runoff following the application of hydrochar. However, the photochemical behavior of HDOM remains unclear. The photo-transformation of HDOM was analyzed by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), multiple spectroscopy methods, high-performance liquid chromatography, and combining synchronous fluorescence and Fourier-transform infrared spectroscopy with two-dimensional correlation spectroscopy.

Efficacy and safety of sacubitril/allisartan for the treatment of primary hypertension: a phase 2 randomized, double-blind study.

This randomized, double-blind phase 2 study assessed the efficacy and safety of sacubitril/allisartan, an angiotensin receptor neprilysin inhibitor, compared with placebo in Chinese patients with mild to moderate hypertension. Eligible patients aged 18-75 years (n = 235) with mild to moderate hypertension were randomized to receive sacubitril/allisartan 120 mg (n = 52), sacubitril/allisartan 240 mg (n = 52), sacubitril/allisartan 480 mg (n = 52), placebo (n = 26) or olmesartan 20 mg (n = 53) once daily for 8 weeks. The primary end point was a reduction in clinic systolic blood pressure from baseline with different doses of sacubitril/allisartan versus placebo at 8 weeks.

Efficient photocatalysis of tetracycline hydrochloride (TC-HCl) from pharmaceutical wastewater using AgCl/ZnO/g-CN composite under visible light: Process and mechanisms.

AgCl/ZnO/g-CN, a visible light activated ternary composite catalyst, was prepared by combining calcination, hydrothermal reaction and in-situ deposition processes to treat/photocatalyse tetracycline hydrochloride (TC-HCl) from pharmaceutical wastewater under visible light. The morphological, structural, electrical, and optical features of the novel photocatalyst were characterized using scanning electron microscopy (SEM), UV-visible light absorption spectrum (UV-Vis DRS), X-ray diffractometer (XRD), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), and transient photocurrent techniques. All analyses confirmed that the formation of heterojunctions between AgCl/ZnO and g-CN significantly increase electron-hole transfer and separation compared to pure ZnO and g-CN.

[Development of Zeolite Loaded Mg-La-Fe Ternary (hydr) oxides for Treatment of Low Concentration Phosphate Wastewater].

A novel Mg-La-Fe ternary (hydr)oxide magnetic zeolite adsorbent (MLFZ) was prepared using the hydrothermal method and employed for effective phosphate removal in this study. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) indicated that the MLFZ presented an amorphous surface with Mg, Fe, and La dispersed on the surface of the zeolite. The isothermal adsorption and kinetics results showed that the adsorption behavior of the MLFZ was consistent with that of the Langmuir isothermal model and quasi-second-order kinetics model.

Antimicrobial Resistance Research Collaborations in Asia: Challenges and Opportunities to Equitable Partnerships.

Antimicrobial Resistance is recognized as a major threat to global health security. The WHO Southeast Asia region is dubbed a "global hub for AMR emergence", as it runs the highest risk for AMR emergence among all WHO regions in Asia. Hence, there is a need for Asia-centric, collaborative AMR research aligned with the true needs and priorities of the region.

Phosphate removal from actual wastewater via La(OH)-CN adsorption: Performance, mechanisms and applicability.

In this study, La(OH) nanoparticles were immobilized on CN to effectively restrict their aggregation and subsequently enhance the La utilization efficiency to promote phosphate adsorption. The prepared La(OH)-CN nanocomposite was characterized by SEM, XRD, FTIR, XPS, BET and Zeta potential analysis. Batch and continuously-fed (fixed-bed column) experiments to assess the adsorption performance of La(OH)-CN showed that the composite exhibits superior utilization efficiency, resulting to relatively quick adsorption with a short equilibrium time of 30 min.

Effect of axitinib regulating the pathological blood-brain barrier functional recovery for glioblastoma therapeutics.

Aims: Dysfunction of the blood-brain barrier (BBB) is a prominent pathological feature of glioblastoma (GBM). Vascular endothelial growth factor (VEGF) is confirmed to be abnormally elevated in the pathogenesis of GBM, causing BBB pathological disruption, which further allows the leakage of neurotoxic blood-derived molecules into the central nervous system (CNS), interfering brain homeostasis and leading to poor patient outcome. Since BBB is an integral and pivotal part of the brain microenvironment, which strongly supports the occurrence and the pathological progression of GBM, here we have selected the VEGFR antagonist axitinib as a BBB functional regulator and hypothesized to regulate pathological BBB restoration for GBM effective treatment.

A randomized, double-blind, placebo-controlled, single, and multiple dose-escalation Phase I clinical trial to investigate the safety, pharmacokinetic, and pharmacodynamic profiles of oral S086, a novel angiotensin receptor-neprilysin inhibitor, in healthy Chinese volunteers.

Background: This study evaluated the safety, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of single ascending doses (SAD) and multiple ascending doses (MAD) of S086 in healthy Chinese volunteers.

Research Design And Methods: This randomized, double-blind, placebo-controlled, Phase I clinical trial enrolled 113 subjects, including 65 subjects in the SAD (60-1080 mg) study and 48 subjects in the MAD study (180-720 mg). The safety, PK (sacubitril, LBQ657, and EXP3174) and PD (MAD study: blood pressure, pulse) of S086 were assessed.

Biowaste hydrothermal carbonization aqueous product application in rice paddy: Focus on rice growth and ammonia volatilization.

Hydrothermal carbonization (HTC) is known as a green biomass conversion technology. However, it often suffers from the issue of disposing hydrothermal carbonization aqueous products (HCAP). Based on the characterization and composition of acidic HCAP, a rice paddy soil column experiment was conducted to observe the effects of HCAP on ammonia (NH) volatilization form paddy soil and rice yield.

[Effects of Film Materials on Ammonia Volatilization Emissions from a Paddy System After Reducing Nitrogen Fertilizer Application].

Ammonia volatilization emissions constitute the main pathway of nitrogen loss from paddy systems. Present control technologies are based on reducing the amount of nitrogen fertilizer applied. However, ratio of nitrogen loss through ammonia volatilization emissions has not changed, and it has become a bottleneck for promoting nitrogen use efficiency.

[Fabrication of La-MHTC Composites for Phosphate Removal: Adsorption Behavior and Mechanism].

Lanthanum (La)-based materials have shown great potential for phosphate removal owing to the strong affinity between La and phosphate. In this study, magnetic hydrothermal biochar immobilized La(OH) (La-MHTC) were prepared and used as phosphate adsorbents. Hydrochar was produced by the hydrothermal carbonization process (220℃, 2 h).