The basic helix-loop-helix (bHLH) transcription factors (TFs) play important roles in various plant developmental and biological processes. However, the precise mechanisms by which bHLH TFs regulate fruit ripening warrant further investigation. Polyamine oxidase (PAO) is crucial for polyamine (PA) catabolism and plays crucial roles in fruit ripening.
View Article and Find Full Text PDFThe phononic crystals composed of soft materials have received extensive attention owing to the extraordinary behavior when undergoing large deformations, making it possible to provide tunable band gaps actively. However, the inverse designs of them mainly rely on the gradient-driven or gradient-free optimization schemes, which require sensitivity analysis or cause time-consuming, lacking intelligence and flexibility. To this end, a deep learning-based framework composed of a conditional variational autoencoder and multilayer perceptron is proposed to discover the mapping relation from the band gaps to the topology layout applied with prestress.
View Article and Find Full Text PDFObjective: Wet distiller's grains (WDG) are rich in crude protein, yet challenging to preserve. Nevertheless, incorporating WDG into total mixed ration (TMR) silage holds promise for enhancing fermentation quality. This study investigated the effects of varying WDG proportions on nitrogen composition, fermentation quality, and microorganisms in TMR silage.
View Article and Find Full Text PDFUnlabelled: The study aims to investigate the clinicopathological significance of MRPL24 in human cancers, with a particular focus on breast cancer (BC). Comprehensive bioinformatics analyses were conducted using data from The Cancer Genome Atlas (TCGA) and various advanced database, including cBioPortal, UALCAN, TIMER, Prognoscan, TISIDB, KM Plotter, and The Human Protein Atlas, to provide a detailed evaluation of MRPL55's role in cancer. The findings were further validated through experimental studies.
View Article and Find Full Text PDFSmall molecules that can bind to specific cells have broad application in cancer diagnosis and treatment. Screening large chemical libraries against live cells is an effective strategy for discovering cell-targeting ligands. The DNA-encoded chemical library (DEL or DECL) technology has emerged as a robust tool in drug discovery and has been successfully utilized in identifying ligands for biological targets.
View Article and Find Full Text PDFTardigrades are captivating organisms known for their resilience in extreme environments, including ultra-high-dose radiation, but the underlying mechanisms of this resilience remain largely unknown. Using genome, transcriptome, and proteome analysis of , we explored the molecular basis contributing to radiotolerance in this organism. A putatively horizontally transferred gene, DOPA dioxygenase 1 (), responds to radiation and confers radiotolerance by synthesizing betalains-a type of plant pigment with free radical-scavenging properties.
View Article and Find Full Text PDFIntroduction: Hyperpigmentation disorders are caused by excess production of the pigment melanin, catalyzed by the enzyme tyrosinase. Novel tyrosinase inhibitors are needed as therapeutic agents to treat these conditions.
Method: To discover new inhibitors, we performed a virtual screening of the ZINC20 library containing 1.
Among the components of high-tech ships, the structural complexity of the propeller profile requires a high degree of flexibility in the CNC polishing machine. In addressing this requirement, the study formulates the flexible optimization problem pertaining to research on the propeller CNC polishing machine. A comprehensive analysis is undertaken to scrutinize the geometric features of the propeller and the phenomenon of polished contact.
View Article and Find Full Text PDFMiddle infrared stimulation (MIRS) and vibrational strong coupling (VSC) have been separately applied to physically regulate biological systems but scarcely compared with each other, especially at identical vibrational frequencies, though they both involve resonant mechanism. Taking cell proliferation and migration as typical cell-level models, herein, we comparatively studied the nonthermal bioeffects of MIRS and VSC with selecting the identical frequency (53.5 THz) of the carbonyl vibration.
View Article and Find Full Text PDFIt's of great challenge to address for heavy metal-contaminated soil. Once the farmland is contaminated with heavy metals, the microbial ecology of the plant rhizosphere will change, which in turn impacts crop productivity and quality. However, few studies have explored the effects of heavy metals on plant rhizosphere microbes in farmland and the role that plant cultivation plays in such a phytoremediation practice.
View Article and Find Full Text PDFTardigrades, commonly known as water bears, are enigmatic organisms characterized by their remarkable resilience to extreme environments despite their simple and compact body structure. To date, there is still much to understand about their evolutionary and developmental features contributing to their special body plan and abilities. This research provides preliminary insights on the conserved and specific gene expression patterns during embryonic development of water bears, focusing on the species Hypsibius exemplaris.
View Article and Find Full Text PDFThe current state of drug delivery systems allows for the resolution of specific issues like inadequate solubility, limited targeting capabilities, and complex preparation processes, requiring tailored designs for different drugs. Yet, the major challenge in clinical application lies in surmounting these obstacles with a universal carrier that is effective for a variety of anticancer drugs. Herein, with the help of computer simulation, we rationally design ultrashort peptides GY and CCYRGD, which can co-assemble with hydrophobic anticancer drugs into nanoparticles with enhanced solubility, targeting ability and anticancer efficacy.
View Article and Find Full Text PDFColorectal cancer (CRC) is a highly prevalent and lethal malignancy worldwide. Although immunotherapy has substantially improved CRC outcomes, intolerance remains a major concern among most patients. Considering the pivotal role of the tumor microenvironment (TME) in tumor progression and treatment outcomes, profiling the TME at the transcriptomic level can provide novel insights for developing CRC treatment strategies.
View Article and Find Full Text PDFIn this study, the fundamental but previously overlooked factors of charge generation efficiency and light extraction efficiency (LEE) are explored and collaboratively optimized in tandem quantum-dot light-emitting diodes (QLEDs). By spontaneously forming a microstructured interface, a bulk-heterojunction-like charge-generation layer composed of a poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)/ZnO bilayer is fabricated and an ideal charge-generation efficiency surpassing 115% is obtained. The coupling strength of the waveguide mode for the top unit and the plasmon polariton loss for the bottom unit are highly suppressed using precise thickness control, which increases the LEE of the tandem devices.
View Article and Find Full Text PDFDNA-encoded chemical libraries (DELs) have become a powerful technology platform in drug discovery. Dual-pharmacophore DELs display two sets of small molecules at the termini of DNA duplexes, thereby enabling the identification of synergistic binders against biological targets, and have been successfully applied in fragment-based ligand discovery and affinity maturation of known ligands. However, dual-pharmacophore DELs identify separate binders that require subsequent linking to obtain the full ligands, which is often challenging.
View Article and Find Full Text PDFF-box only protein 8 (FBXO8) is a recently identified member of the F-box proteins, showcasing its novelty in this protein family. Extensive research has established FBXO8's role as a tumor suppressor in various cancers, including hepatocellular carcinoma, and colorectal cancer, Nevertheless, its functional, mechanistic, and prognostic roles in primary and metastatic breast cancer, particularly in different molecular subtypes of breast cancer, various stages, as well as its potential implications in immunotherapy, tumor microenvironment, and prognostic survival among breast cancer patients, remain unexplored. In this article, we employed a multi-dimensional investigation leveraging TCGA, TIMER, TISIDB, STRING, MEXPRESS, UALCAN, and cBioPortal databases to explore the underlying suppression mechanism of FBXO8 in breast cancer.
View Article and Find Full Text PDFHuan Jing Ke Xue
December 2023
To improve polishing performance and reduce the environmental pollution of chemical mechanical polishing (CMP) tests, mesoporous shell/core silica abrasives were prepared, and a novel green CMP slurry was developed, including sorbitol, hydrogen peroxide and sodium carbonate. Prior to CMP, fused silica was roughly polished with ceria slurry. Using developed mesoporous abrasives, surface roughness is reduced from 0.
View Article and Find Full Text PDFObjective: Vanin-1 (VNN1) is a pantetheinase that catalyses the hydrolysis of pantetheine to produce pantothenic acid and cysteamine. Our previous studies have shown that the VNN1 is specifically expressed in chicken liver which negatively regulated by microRNA-122. However, the functions of the VNN1 in lipid metabolism in chicken liver haven't been elucidated.
View Article and Find Full Text PDFBackground: Immune checkpoint inhibitors (ICIs) therapy can be complicated by their potential cardiovascular toxicities, including myocarditis. Nowadays, no prospective trials have focused on ICI-associated myocarditis optimized management. Available evidence only come from case reports or series.
View Article and Find Full Text PDF() can tolerate various extreme environments including radiation. Protein phosphorylation plays an important role in radiation resistance mechanisms; however, there is currently a lack of systematic research on this topic in . Based on label-free (phospho)proteomics, we explored the dynamic changes of under various doses of heavy ion irradiation and at different time points.
View Article and Find Full Text PDFTwo anthryl-functionalized cyanide-bridged [FeCo] cube complexes, [(pzTp)Fe(CN)Co(TpEtOAn)][OTf]·8MeCN·7EtO (1) and [NEt][(pzTp)Fe(CN)Co(TpEtOAn)][OTf]·5MeCN·2EtO (2) (pzTp = tetrapyrazolylborate, TpEtOAn = 2,2,2-tris-(pyrazol-1-yl)ethoxy(9-methyl-anthracene)), were synthesized and characterized. The crystallographic study revealed that the [FeCo] cubes are arranged into a linear supramolecular chain through significant anthryl-anthryl π-π stacking interactions in complex 1, whereas a zigzag supramolecular 1D assembly is observed in 2. The magnetic measurements showed that both compounds exhibited incomplete transitions from the paramagnetic {FeIIILS(μ-CN)CoIIHS} state to the diamagnetic {FeIILS(μ-CN)CoIIILS} state at about 200 K.
View Article and Find Full Text PDFThe solar unmanned aerial vehicle (UAV) route planning needs to comprehensively consider the conversion efficiency of solar cells under the influence of solar ground reflection radiation and sky scattering radiation. On the one hand, it is necessary to consider the cost of radar threat, mileage energy consumption, mountain impact and other costs. On the other hand, it is also necessary to consider the influence of high threat, mountain shadow occlusion cost, and cloud shading cost on solar photovoltaic conversion efficiency.
View Article and Find Full Text PDFThe measurement of tumor biomarker levels is of great significance for early diagnosis of breast cancer. The combination diagnosis of multiple tumor biomarkers will significantly improve the accuracy of early diagnosis. Here, we successfully developed a dual-ratio fluorescent sensing platform for the detection of breast cancer biomarkers (PTK7, miRNA-21) using single excitation triple-signal detection.
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