[Establishment and validation of a sepsis 28-day mortality prediction model based on the lactate dehydrogenase-to-albumin ratio in patients with sepsis].

Objective: To develop and validate a predictive model of 28-day mortality in sepsis based on lactate dehydrogenase-to-albumin ratio (LAR).

Methods: Sepsis patients diagnosed in the department of intensive care medicine of the First Affiliated Hospital of Soochow University from August 1, 2017 to September 1, 2022 were retrospective selected. Clinical data, laboratory indicators, disease severity scores [acute physiology and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA)] were collected.

High-efficiency nonlinear frequency conversion enabled by optimizing the ferroelectric domain structure in -cut LNOI ridge waveguide.

Photonic devices based on ferroelectric domain engineering in thin film lithium niobate are key components for both classical and quantum information processing. Periodic poling of ridge waveguide can avoid the selective etching effect of lithium niobate, however, the fabrication of high-quality ferroelectric domain is still a challenge. In this work, we optimized the applied electric field distribution, and rectangular inverted domain structure was obtained in the ridge waveguide which is beneficial for efficient nonlinear frequency conversions.

Review and Future Perspectives of Stimuli-Responsive Bridged Polysilsesquioxanes in Controlled Release Applications.

Bridged polysilsesquioxanes (BPSs) are emerging biomaterials composed of synergistic inorganic and organic components. These materials have been investigated as ideal carriers for therapeutic and diagnostic systems for their favorable properties, including excellent biocompatibility, physiological inertia, tunable size and morphology, and their extensive design flexibility of functional organic groups to satisfy diverse application requirements. Stimuli-responsive BPSs can be activated by both endogenous and exogenous stimuli, offering a precise, safe, and effective platform for the controlled release of various targeted therapeutics.

A review of Lycium barbarum polysaccharides: Extraction, purification, structural-property relationships, and bioactive molecular mechanisms.

Lycium barbarum L. is of great significance medicinal and edible plant, which is native to N. & Central China.

Establishment and transcriptome analysis of single blastomere-derived cell lines from zebrafish.

Maintaining chromosome euploidy in zebrafish embryonic cells is challenging because of the degradation of genomic integrity during cell passaging. In this study, we report the derivation of zebrafish cell lines from single blastomeres. These cell lines have a stable chromosome status attributed to BMP4 and exhibit continuous proliferation in vitro.

Fe,Ce Co-Doped NiS/NiS Polymorphism Nanosheets With Improved Electrocatalytic Activity and Stability for Water Oxidation.

Balancing the relationship between electrocatalytic activity and stability of sulfide catalysts during oxygen evolution reaction (OER) has been attracting extensive research interest. Here, a simple electrodeposition-vulcanization two-step route was designed to successfully construct nickel foam supported sheet-like Fe,Ce-codoped NiS/NiS polymorphism catalyst (labeled as Fe,Ce-NiS/NiS/NF). Electrochemical measurements showed that the as-obtained Fe,Ce-NiS/NiS/NF electrode presented excellent OER electrocatalytic performances.

Evolution characteristics and multi-scenario prediction of habitat quality in Yulin City based on PLUS and InVEST models.

As a major energy city in China, Yulin City has faced huge challenges to the ecological environment with its rapid economic development and rapid urbanization. Therefore, it is of great significance to study the impact of land use changes on habitat quality. Based on three periods of land use data in Yulin City in 1995, 2005 and 2015, the PLUS model was used to simulate the land use changes in 2015.

Characterization and expression profiles of the ZmLBD gene family in Zea mays.

Background: The Lateral Organ Boundaries Domain (LBD) gene family is a family of plant-specific transcription factors (TFs) that are widely involved in processes such as lateral organ formation, stress response, and nutrient metabolism. However, the function of LBD genes in maize remains poorly understood.

Methods And Results: In this study, a total of 49 ZmLBD genes were identified at the genome-wide level of maize, they were classified into nine branches based on phylogenetic relationships, and all of them were predicted to be nuclear localized.

The impact of caregiver burden on quality of life in family caregivers of patients with advanced cancer: a moderated mediation analysis of the role of psychological distress and family resilience.

Background: The caregiver burden frequently experienced by family members tending to advanced cancer patients significantly impacts their psychological well-being and quality of life (QoL). Although family resilience might function as a mitigating factor in this relationship, its specific role remains to be elucidated. This study aims to probe the mediating effect of psychological distress on the relationship between caregiver burden and QoL, as well as the moderating effect of family resilience.

High-throughput sequencing reveals hub genes for human early embryonic development arrest fertilization: a pilot study.

Many clinical studies have shown that embryos of fertilization (IVF) are often prone to developmental arrest, which leads to recurrent failure of IVF treatment. Early embryonic arrest has always been an urgent clinical problem in assisted reproduction centers. However, the molecular mechanisms underlying early embryonic development arrest remain largely unknown.

High performance polymeric aluminum silicate sulfate (PASS) flocculant from abandoned molecular sieve.

PASS is an innovative inorganic polymer flocculant (IPF), which possesses the advantages of a polysilicate/aluminum sulfate-based flocculant. Recently, solid wastes rich in Si and Al, such as kaolinite, rice husks, and abandoned molecular sieves (AMS) have been recognized as promising raw materials for the synthesis of flocculants. The present study involved the synthesis of PASS flocculant derived from AMS.

Comprehensive evaluation of the underground space resources in Xianyang city.

With the rapid development of urbanization and the sharp increase in population, urban land is becoming increasingly scarce. The efficient and reasonable development of the underground space is a crucial way to solve the problem of urban diseases, and comprehensive evaluation of urban underground space resources is an important basic task to achieve reasonable planning of the underground space. Adopting Xianyang city as an example, in this paper, we comprehensively evaluated the underground space resources in the main urban area and established evaluation models for the amount of resources available for development, development difficulty, potential value, and comprehensive quality of the underground space.

Genome-Wide Identification of the RR Gene Family and Its Expression Analysis in Response to TDZ Induction in .

The cytokinin response regulator (RR) gene is essential for cytokinin signal transduction, which plays a crucial role in plant growth and development. Here, we applied bioinformatics to 's genome to identify its RR gene family and systematically analyzed their gene characteristics, phylogenetic evolution, chromosomal localization, collinearity analysis, promoter cis-elements, and expression patterns. Overall, 33 genes were distinguished and classified into three types.

Ac-SDKP promotes KIF3A-mediated β-catenin suppression through a ciliary mechanism to constrain silica-induced epithelial-myofibroblast transition.

Kinesin family member 3 A (KIF3A) decrease have been reported in silicotic patients and rats. However, the detailed mechanisms of KIF3A in silicosis remain unknown. In this study, we demonstrated that KIF3A effectively blocked the expression of β-catenin and downstream myocardin-related transcription factor (MRTF)-A/serum response factor (SRF) signaling, thus inhibiting silica-induced epithelial-myofibroblast transition (EMyT).

Carbon and oxygen isotope characteristics of carbonate rocks in the Mesoproterozoic Jixian System of the Ordos Basin and their implications.

The paleoenvironment of Jixian carbonate rocks in the Mesoproterozoic Ordos Basin is studied by carbon and oxygen isotope analyses, diagenetic environment analysis, and the restoration of paleosalinity and paleotemperature. The results indicate that the carbonate rocks of the Jixian System have always been in a near-surface environment and have not been deeply buried. The ranges of variation in δC and δO are relatively narrow, ranging from - 5.

Exercise training inhibits macrophage-derived IL-17A-CXCL5-CXCR2 inflammatory axis to attenuate pulmonary fibrosis in mice exposed to silica.

Exposure to crystalline silica leads to health effects beyond occupational silicosis. Exercise training's potential benefits on pulmonary diseases yield inconsistent outcomes. In this study, we utilized experimental silicotic mice subjected to exercise training and pharmacological interventions, including interleukin-17A (IL-17A) neutralizing antibody or clodronate liposome for macrophage depletion.

Dynamic changes in lactate levels within the first 24 hours in septic patients as a prognostic indicator: A retrospective cohort study utilizing latent class growth analysis.

Elevated lactate levels are common in sepsis patients. This study aimed to assess the effect of dynamic changes in lactate levels within the first 24 hours following admission on patient prognosis. We extracted data from the Medical Information Mart for Intensive Care (MIMIC)-IV database and classified patients using latent class growth analysis (LCGA).

Using IV-Tubing "Bridge" from Splenic Artery to Superior Mesentery Artery to Create a Single Arterial Cannulation for Normothermic Machine Perfusion When Donor Liver Has Replaced Right Hepatic Artery.

BACKGROUND The presence of anatomical variations of the hepatic artery poses a challenge for normothermic machine perfusion (NMP). Here, we describe our experience of creating a single arterial cannulation for NMP in 3 donor livers with replaced right hepatic artery. CASE REPORT Three donor livers with replaced right hepatic artery were perfused using NMP (OrganOx® metra®) for liver transplantation.

Family resilience and its influencing factors among advanced cancer patients and their family caregivers: a multilevel modeling analysis.

Background: Cancer is highly prevalent worldwide. Family resilience is a positive variable that helps families burdened by advanced cancer to cope effectively. This study aimed to describe the family resilience of advanced cancer patients and caregivers in dyads and identify its influencing factors at the individual and dyadic levels.

Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway.

Silicosis is a pulmonary disease caused by the inhalation of silica. There is a lack of early and effective prevention, diagnosis, and treatment methods, and addressing silicotic fibrosis is crucial. Quercetin, a flavonoid with anti-carcinogenic, anti-inflammatory, and antiviral properties, is known to have a suppressive effect on fibrosis.

In Situ Super-Hindrance-Triggered Multilayer Cracks for Random Lasing in π-Functional Nanopolymer Films.

In situ self-assembly of semiconducting emitters into multilayer cracks is a significant solution-processing method to fabricate organic high- lasers. However, it is still difficult to realize from conventional conjugated polymers. Herein, we create the molecular super-hindrance-etching technology, based on the π-functional nanopolymer PG-Cz, to modulate multilayer cracks applied in organic single-component random lasers.