Conductive hydrogels: intelligent dressings for monitoring and healing chronic wounds.

Conductive hydrogels (CHs) represent a burgeoning class of intelligent wound dressings, providing innovative strategies for chronic wound repair and monitoring. Notably, CHs excel in promoting cell migration and proliferation, exhibit powerful antibacterial and anti-inflammatory properties, and enhance collagen deposition and angiogenesis. These capabilities, combined with real-time monitoring functions, play a pivotal role in accelerating collagen synthesis, angiogenesis and continuous wound surveillance.

Excellent Energy Storage and Charge-Discharge Performance in (PbCa)(ZrSn)O Antiferroelectric Ceramics.

Lead-based antiferroelectric (AFE) ceramics have the advantages of high power density, fast charge and discharge speed, and the electric-field-induced AFE-FE phase transition, making them one of the potential dielectric energy storage materials. However, the energy storage density still needs to be improved. In this work, (PbCa) (ZrSn)O (PCZS, = 0.

High-Throughput Screening and General Synthesis Strategy of Single-Atom Nanozymes for Oral Squamous Cell Carcinoma Therapy.

Single-atom nanozymes (SAzymes), with their superior enzyme-like catalytic activity, have emerged as promising candidates for oncology therapeutics. The well-defined structures of SAzymes make them well predictable by experiences and theoretical calculation. However, the effects of metal center species and coordination environments on enzyme-like activity are variable, and screening catalytic activity by artificial experiments is challenging.

Substance migration in the synthesis of single-atom catalysts.

Substance migration is universal and crucial in the synthesis of catalysts, which directly affects their existing form and the micro-structure of their active sites. Realizing migration during the synthesis of single-atom catalysts (SACs) is beneficial for not only increasing their metal loading capacity but also manipulating the electronic structures (coordination structure, long-range interactions, ) of their metal sites. This review summarizes the thermodynamics and kinetic processes involved in the synthesis of SACs to unveil the fundamental principles involved in their synthesis.

Synergistic enhancement of electrochemical alcohol oxidation by combining NiV-layered double hydroxide with an aminoxyl radical.

Electrochemical alcohol oxidation (EAO) represents an effective method for the production of high-value carbonyl products. However, its industrial viability is hindered by suboptimal efficiency stemming from low reaction rates. Here, we present a synergistic electrocatalysis approach that integrates an active electrode and aminoxyl radical to enhance the performance of EAO.

Janus Photothermal Films with Orientated Plasmonic Particle-in-Cavity Surfaces Enabling Heat Control in Solar-Thermal-Electric Generators.

Solar thermoelectric generators (STEGs) consisting of solar absorbers and thermoelectric generators (TEGs) can utilize solar energy to generate electrical power. However, performances of STEGs are limited by the heat losses of solar absorbers in air, which become more and more significant with an increase in the solar absorbing area. Herein, we describe the preparation of Au@AgPd nanostructure monolayer/poly(vinyl alcohol) (PVA) Janus photothermal films with broadband plasmonic absorption in the visible and near-infrared regions.

Microneedles based on hyaluronic acid-polyvinyl alcohol with antibacterial, anti-inflammatory, and antioxidant effects promote diabetic wound healing.

Diabetic wound healing has become one of the major clinical burdens due to uncontrolled bacterial growth and an increase in the risk of various microbial infections. Despite excellent antioxidant properties, the poor aqueous solubility of resveratrol (RES) hampers its applicability. In this study, we proposed a novel multifunctional microneedle patch loaded with RES-encapsulated polymeric micelles.

Transition Metal (Molybdenum)-Doped Drug-like Conformational Nanoarchitectonics with Altered Valence States (Mn/Mn and Mo/Mo) for Augmented Cancer Theranostics.

Despite the advancements in cancer therapy, delivering active pharmaceutical ingredients (APIs) using nanoparticles remains challenging due to the failed conveyance of the required drug payload, poor targeting ability, and poor biodistribution, hampering their clinical translation. Recently, the appropriate design of materials with intrinsic therapeutic functionalities has garnered enormous interest in the development of various intelligent therapeutic nanoplatforms. In this study, we demonstrate the fabrication of transition metal (molybdenum, Mo)-doped manganese dioxide (MnO) nanoarchitectures, exhibiting diagnostic (magnetic resonance imaging, MRI) and therapeutic (chemodynamic therapy, CDT) functionalities.

Mental Health Literacy Among Urban and Rural Residents of Guangdong Province, China.

Purpose: The study aims to understanding the mental health literacy level of urban and rural residents in Guangdong Province, the first major province in China, and its influencing factors is crucial.

Methods: A multi-stage stratified equal-volume random sampling method was adopted in October-December 2022 to select permanent residents aged 18 years and above in Guangdong Province for the questionnaire survey, which consisted of a general demographic information questionnaire and a national mental health literacy questionnaire. Rao-Scott -test with correction based on sampling design, independent samples -test and binary multivariate logistic regression analysis were performed.

Engineered liver-derived decellularized extracellular matrix-based three-dimensional tumor constructs for enhanced drug screening efficiency.

The decellularized extracellular matrix (dECM) has emerged as an effective medium for replicating the -like conditions of the tumor microenvironment (TME), thus enhancing the screening accuracy of chemotherapeutic agents. However, recent dECM-based tumor models have exhibited challenges such as uncontrollable morphology and diminished cell viability, hindering the precise evaluation of chemotherapeutic efficacy. Herein, we utilized a tailor-made microfluidic approach to encapsulate dECM from porcine liver in highly poly(lactic--glycolic acid) (PLGA) porous microspheres (dECM-PLGA PMs) to engineer a three-dimensional (3D) tumor model.

Photothermal and Antibacterial PDA@Ag/SerMA Microneedles for Promoting Diabetic Wound Repair.

Diabetic foot ulcer (DFU) is a common and severe complication of diabetes characterized by wound neuropathy, ischemia, and susceptibility to infection, making its treatment difficult. Dressings are commonly used in treating diabetic wounds; however, they have disadvantages, including lack of flexibility and mechanical strength, lack of coagulation activity, resistance to biodegradation, and low drug delivery efficiency. Developing more effective strategies for diabetic wound treatment has become a new focus.

Psychometric properties of International Trauma Questionnaire (ITQ) and symptom structure of complex post-traumatic stress disorder among Chinese patients with MDD.

Aims: To assess the validity and internal reliability of the International Trauma Questionnaire (ITQ) among patients diagnosed with major depressive disorder (MDD) and to explore the network structure of Complex post-traumatic stress disorder (CPTSD) among MDD patients in China.

Methods: Eligible individuals were recruited from a large tertiary hospital in Guangdong Province. Trained researchers conducted in-person interviews and administered self-report questionnaires, including demographics, medical information, and psychological assessments.

Curing and Cross-Linking Processes in the Poly(3,3-bis-azidomethyl oxetane)-tetrahydrofuran/Toluene Diisocyanate/Trimethylolpropane System: A Density Functional Theory and Accelerated ReaxFF Molecular Dynamics Investigation.

The physical and chemical properties of solid propellant are influenced by the composition and structure of the binder, with its network structure being formed through curing and cross-linking reactions. Therefore, understanding the mechanisms of these reactions is crucial. In this study, we investigated the curing and cross-linking mechanisms of poly(3,3-bis-azidomethyl oxetane)-tetrahydrofuran (PBT), toluene diisocyanate (TDI), and trimethylolpropane (TMP) using a combination of density functional theory (DFT) calculations and accelerated ReaxFF molecular dynamics (MD) simulations.

Revealing the Size and Potential Dependent DO Microkinetics on Pt Nanoparticles Using Grand Canonical Ensemble Modeling.

Revealing the potential and nanoparticle size effect is significant for understanding the electrochemical microkinetic behaviors under real reaction conditions. Herein, an efficient strategy of combining the robust fully converged constant potential (FCP) algorithm and the size dependent site distribution rule assumption was proposed. A simple reaction of isotopic DO/HO adsorption and dissociation on Pt nanoparticles was set as the model reaction.

Biosensing of Cysteine through the Induction of Oxygen Vacancies in a Cu/Zr Heterostructure Prepared by Supercritical Antisolvent Technique.

There has been a growing emphasis on facile preparation of binary heterogeneous composite materials. Leveraging the eco-friendly efficiency of supercritical CO technology, we achieved precise control over the influencing factors of mass transfer, enabling the accurate modulation of the resulting product morphology and properties. In the current study, CuO/ZrO composite materials were prepared using this technology and calcined to obtain electrode materials for the detection of cysteine (Cys).

Air Leakage Characteristics of Gas Boreholes in Deep Coal Seams and Application of Short-Hole Grouting and Plugging.

Drilling for gas extraction is widely used as the main approach to manage gas in mines. However, gas leakage during borehole extraction reduces the root cause of the effectiveness of gas extraction. Given that forming a normal hole in the prominent coal seam of the Qingdong Coal Mine is impossible and that air leakage leads to difficulties in prepumping gas in the coal seam, we selected coal seam 3# as the object of this study.

Prussian blue nanoparticle-based pH-responsive self-assembly for enhanced photothermal and chemotherapy of tumors.

In recent years, there has been growing interest in size-transformable nanoplatforms that exhibit active responses to acidic microenvironments, presenting promising prospects in the field of nanomedicine for tumor therapy. However, the design and fabrication of such size-adjustable nanotherapeutics pose significant challenges compared to size-fixed nanocomposites, primarily due to their distinct pH-responsive requirements. In this study, we developed pH-activated-aggregating nanosystems to integrate chemotherapy and photothermal therapy by creating size-transformable nanoparticles based on Prussian blue nanoparticles (PB NPs) anchored with acid-responsive polyoxometalates (POMs) quantum dots via electrostatic interactions (PPP NPs).

Application of Stereo Digital Image Correlation on Facial Expressions Sensing.

Facial expression is an important way to reflect human emotions and it represents a dynamic deformation process. Analyzing facial movements is an effective means of understanding expressions. However, there is currently a lack of methods capable of analyzing the dynamic details of full-field deformation in expressions.