Integrating network pharmacology and model to reveal the cardiovascular protective effects of kaempferol-3--rutinoside on heart failure.

Kaempferol-3--rutinoside (KR) has an excellent cardioprotective effect, but its mechanism of action is not clear. Network pharmacology was used to predict the signaling pathways, whereas molecular docking was used for preliminary validation of KR binding to targets. AMI model rats with ligated left anterior descending coronary arteries were established.

Ezrin expression in female reproductive tissues: A review of regulation and pathophysiological implications.

Ezrin, a plasma membrane-microfilament linker, is a cytoskeletal organizer involved in many cellular activities by binding to the membrane protein-ezrin-cytoskeletal protein complex and regulating downstream signal transduction. Increasing evidence demonstrates that ezrin plays an important role in regulating cell polarity, proliferation and invasion. In this study, we analyzed the effects of ezrin on oocytes, follicle development, embryo development and embryo implantation.

2-D path following for fixed wing UAV using global fast terminal sliding mode control.

This paper considers the finite time convergence problem of 2-D path following for fixed wing unmanned air vehicle. Firstly, the UAV path following model is divided into an outer guidance loop and an inner control loop. Then, the guidance loop and control loop controllers of the UAV are derived by global fast terminal sliding mode control technique, which is able to guarantee the system state variables converge to expected values in finite time and eliminate the chattering phenomenon caused by the switching control action.

Pitavastatin attenuates AGEs-induced mitophagy via inhibition of ROS generation in the mitochondria of cardiomyocytes.

This study aimed to investigate whether pitavastatin protected against injury induced by advanced glycation end products products (AGEs) in neonatal rat cardiomyocytes, and to examine the underlying mechanisms. Cardiomyocytes of neonatal rats were incubated for 48 hours with AGEs (100 μg/mL), receptor for advanced glycation end products (RAGE), antibody (1 μg/mL) and pitavastatin (600 ng/mL). The levels of p62 and beclin1 were determined by Western blotting.

Low-loss channel optical waveguide fabrication in Nd(3+)-doped silicate glasses by femtosecond laser direct writing.

Optical waveguides were fabricated in neodymium-doped silicate glass by using a low-repetition-rate (1 kHz) femtosecond laser inscription. Two different types of waveguide structure are fabricated. In the first, guiding occurs in the focal spot.

[Centrosome amplification and chromosome instability in oral squamous cell carcinomas].

Objective: To investigate the relationship between centrosome abnormalities and aneuploidy in oral squamous cell carcinoma (OSCC) and elucidate the possible underlying mechanisms of chromosome instability (CIN) in OSCC.

Methods: Formalin-fixed, paraffin-embedded tissues of 8 cases of normal oral epithelium and 32 cases of OSCC were examined for centrosome status by using indirect immunofluorescence staining, and chromosome instability (aneuploidy) in some tissues were detected by flow cytometry. The correlation between centrosome abnormalities and aneuploidy in OSCC was statistically analyzed by SPSS12.

[Cyclin E overexpression and centrosome amplification in squamous cell carcinoma of oral cavity].

Objective: To study the correlation between cyclin E protein overexpression and centrosome amplification in oral squamous cell carcinoma (OSCC).

Methods: Formalin-fixed, paraffin-embedded tissues from 12 normal oral epithelium cases and 46 cases of OSCC were studied. Their centrosome status was analyzed by indirect immunofluorescence double staining with antibodies to centrosome protein gamma-tubulin and cytokeratin.

Optical planar waveguide fabricated in Nd:LuVO4 crystal by MeV oxygen implantation.

We report the first time optical planar waveguide fabricated in vanadate laser crystal Nd:LuVO4 by 3.0 MeV oxygen ion implantation with the dose of 6x1014 ions/cm2 at room temperature. After the implantation, an enhanced ordinary refractive index region was formed with a width of about 2.

Low propagation loss of the waveguides in fused quartz by oxygen ion implantation: errata.

The calculated data of propagation loss of the waveguide were incorrect. Corrected data show the actual results in the measurements.

Low propagation loss of the waveguides in fused quartz by oxygen ion implantation.

The planar waveguides have been fabricated in fused quartz by 3.0 MeV oxygen ion implantation at dose of 1x10;15 ions/cm2. The guiding modes were observed at wavelengths of both 633 nm and 1539 nm before and after annealing at 320 masculineC, 450 masculineC and 500 masculineC in 60 min characterized by the prism-coupling method.

Monomode optical waveguide excited at 1540 nm in LiNbO(3) formed by MeV carbon ion implantation at low doses.

The monomode enhanced-index LiNbO(3) waveguide excited at 1540 nm is reported. X-cut LiNbO(3) crystals were implanted at room temperature by 6.0 MeV C(3+) ions with a dose of 2.