Harnessing polysialic acid (PSA)-embedded exudate-absorbing hydrogel for on-demand trigeminal neuralgia treatment.

A key characteristic of trigeminal neuralgia (TN) is cytokine-enriched exudate and a "reactive oxygen species (ROS) storm" generated from the inflammatory cascade, resulting in demyelination of the sensory root of the trigeminal nerve, tissue swelling, and intense electric shock-like pain. The clinically approved drug carbamazepine (CBZ) is capable of inhibiting pain, reducing inflammatory factors, and alleviating oxidative stress, but its clinical application is restricted by its systemic toxicity. Herein, we developed an exudate-absorbing hydrogel incorporating polysialic acid (PSA) and CBZ (F127@PSA@CBZ) for on-demand TN treatment.

[Characteristics of soil pH and exchangeable acidity in red soil profile under different vegetation types].

The characteristics of soil pH and exchangeable acidity in soil profile under different vegetation types were studied in hilly red soil regions of southern Hunan Province, China. The soil samples from red soil profiles within 0-100 cm depth at fertilized plots and unfertilized plots were collected and analyzed to understand the profile distribution of soil pH and exchangeable acidity. The results showed that, pH in 0-60 cm soil from the fertilized plots decreased as the following sequence: citrus orchard > Arachis hypogaea field > tea garden.

Mitigation of cadmium and arsenic in rice grain by applying different silicon fertilizers in contaminated fields.

A field experiment was established to support the hypothesis that application of different silicon (Si) fertilizers can simultaneously reduce cadmium (Cd) and arsenic (As) concentration in rice grain. The "semi-finished product of Si-potash fertilizer" treatment at the high application of 9000 kg/ha (NP+S-KSi9000) significantly reduced the As concentration in rice grain by up to 20.1%, compared with the control.

[Characteristics of soil phosphorous loss under different ecological planting patterns in hilly red soil regions of southern Hunan Province, China].

Taking a large standard runoff plot on a red soil slope in Qiyang County, southern Hunan Province as a case, this paper studied the surface soil phosphorus loss characteristics in the hilly red soil regions of southern Hunan under eight ecological planting patterns. The phosphorus loss from wasteland (T1) was most serious, followed by that from natural sloped cropping patterns (T2 and T3), while the phosphorus loss amount from terrace cropping patterns (T4-T8) was the least, only occupying 9.9%, 37%, 0.