Publications by authors named "Shi-lei Guo"

Objective: To determine the clinical impact of preventive nursing on children with hypospadias and the intervention effect on postoperative complications.

Study Design: Comparative study. Place and Duration of the Study: Department of Urology Surgery, Beijing Children's Hospital Affiliated to Capital Medical University Baoding Hospital, Hebei, China, from August 2019 to July 2021.

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  • The study aimed to compare the effectiveness of microscopic surgery versus conventional surgery for treating penile hypospadias in children, focusing on clinical outcomes and urodynamic measurements.
  • Eighty children were divided into two groups, with one receiving microscopic urethroplasty and the other traditional urethroplasty; various metrics like operation time, blood loss, and complication rates were compared.
  • Results showed that microscopic surgery led to better outcomes, including higher efficacy, less blood loss, shorter hospital stays, and improved urodynamic parameters over time compared to conventional methods.
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Objective: To evaluate the advantages of the laparoscopic approach of tunica vaginalis in the treatment of palpable cryptorchidism.

Study Design: Randomised clinical comparative study.

Place And Duration Of Study: Department of Urology Surgery, Baoding Children's Hospital, Baoding, Hebei, China, from July 2019 to June 2020.

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Objective: To evaluate the effects of conditioned medium of adipose-derived stem cells (ADSC-CM) on efficacy and side effects after fractional carbon dioxide laser resurfacing (FxCR) when treating subjects with facial atrophic acne scars or with skin rejuvenation needs.

Materials And Methods: Twenty-two subjects were enrolled in the study and divided into two groups. Nine subjects were included in skin rejuvenation group and thirteen subjects were included in acne scar group, and all subjects underwent three sessions of FxCR.

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Effective repair of peripheral nerve defects is difficult because of the slow growth of new axonal growth. We propose that "neural-like cells" may be useful for the protection of peripheral nerve destructions. Such cells should prolong the time for the disintegration of spinal nerves, reduce lesions, and improve recovery.

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Photoaging of skin occurs partially due to decreased synthesis and increased degradation of dermal collagen. Antiphotoaging therapy aims to counteract these effects. This study aimed to investigate whether secretory factors from dedifferentiated adipocytes (DAs) could alleviate photoaging in human dermal fibroblasts (HDFs) and in mice and to clarify the underlying mechanism.

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Our previous study showed that after being treated with 5-azacytidine, Nkx2.5(+) human cardiac progenitor cells (CPCs) derived from embryonic heart tubes could differentiate into cardiomyocytes. Although 5-azacytidine is a classical agent that induces myogenic differentiation in various types of cells, the drug is toxic and unspecific for myogenic differentiation.

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  • Scientists studied how using a special liquid from fat cells (ADSC-CM) can help heal skin wounds better after a specific laser treatment (FxCR).
  • They treated 19 people and compared one arm that got the special liquid to the other arm that didn’t.
  • Results showed that the arm with the special liquid healed faster and had less redness, dark spots, and water loss than the control arm.
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  • Researchers studied how high glucose levels cause certain cells in blood vessels to grow too much, which can lead to diabetes-related health problems.
  • They found that a protein called Irf-1 helps control this growth. When Irf-1 is increased, it can speed up cell growth in high glucose, but when it's reduced, the cells slow down.
  • Using antioxidants (which help protect cells), researchers saw that they could stop the fast growth caused by too much Irf-1 and high sugar levels.
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Background: Studies have shown that steroids can improve kidney survival and decrease the risk of proteinuria in patients with Immunoglobulin A nephropathy, but the overall benefit of steroids in the treatment of Immunoglobulin A nephropathy remains controversial. The aim of this study was to evaluate the benefits and risks of steroids for renal survival in adults with Immunoglobulin A nephropathy.

Methodology And Principal Findings: We searched the Cochrane Renal Group Specialized Register, Cochrane Controlled Trial Registry, MEDLINE and EMBASE databases.

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