Publications by authors named "Shi-Yun Lu"
Article Synopsis
- - The study investigates a nonclassical form of Cholesterol Ester Storage Disorder (CESD) that appears to be inherited in an autosomal dominant manner, contrary to previous beliefs about it being autosomal recessive due to mutations in the LIPA gene, which affects lysosomal acid lipase (LAL) activity.
- - Researchers analyzed a Chinese family with 15 members, finding that four living relatives displayed reduced LAL activity and liver dysfunction, while four deceased members likely died from liver failure linked to the disorder.
- - Genetic analysis identified a new heterozygous mutation (c.1133T>C) in the LIPA gene among the living family members, suggesting a potential link between this mutation and the nonclass
Objective: To investigate the clinical efficacy and safety of "3+7" regimen and decitabine + HAG pre-excitation regimen in the treatment of elderly MDS patients with AML transformed by abnormal proliferation of bone marrow.
Methods: Fifty elderly patients with AML transformed by abnormal proliferation of bone marrow in the period from March 2012 to May 2014 were chosen and randomly divided into 2 groups including A group (25 elderly patients treated with "3+7" regimen) and B group (25 elderly patients treated with decitabine+HAG pre-excitation regimen), and the clinical effeicacy, the median survival time and the incidence of drug adverse effects in 2 groups were compared.
Results: The clinical total remission rate in B group was significantly higher than that in A group(P<0.