Publications by authors named "Shi-Yuan Tong"
Article Synopsis
- The hydrolysis step of 2,7-epoxy is crucial for the production of camptothecin (CPT), a compound with potent cancer-fighting properties, yet the specific genes involved have not been previously identified.
- This study identifies three genes (CaEH1-CaEH3) responsible for the epoxide hydrolase activity in Camptotheca acuminata and highlights their ability to catalyze the opening of various oxirane rings.
- Functional tests show that these genes are actively involved in CPT biosynthesis, are expressed in all plant tissues with a concentration in leaves, and suggest a convergence in their evolutionary development from different ancestral genes.
Article Synopsis
- This study investigates the role and importance of CALU in various cancers, primarily focusing on its impact on tumor progression and treatment resistance, especially in breast cancer.
- Researchers analyzed CALU expression and its link to patient outcomes across multiple cancer types, utilizing various databases and experimental methods.
- Findings showed that higher CALU levels are associated with worse prognoses, driven by genomic changes, and CALU plays a significant role in promoting epithelial-mesenchymal transition (EMT) in both cancer cells and cancer-associated fibroblasts (CAFs).
Article Synopsis
- The review discusses how metal ions like iron, copper, zinc, and selenium play complex roles in the development and immune evasion of gliomas, which are a type of brain tumor.
- *Dysregulated metal ion metabolism leads to glioma progression by increasing oxidative stress, promoting blood vessel formation (angiogenesis), and affecting immune cell functions.
- *Therapeutic strategies targeting metal ion pathways, combined with traditional treatments, may improve glioma treatment effectiveness and future research should focus on uncovering new biomarkers and treatment targets.
The majority of neocortical projection neurons are generated indirectly from radial glial cells (RGCs) mediated by intermediate progenitor cells (IPCs) in mice. IPCs are thought to be a great breakthrough in the evolutionary expansion of the mammalian neocortex. However, the precise ratio of neuron production from IPCs and characteristics of RGC differentiation process are still unclear.
View Article and Find Full Text PDFmvPPT: A Highly Efficient and Sensitive Pathogenicity Prediction Tool for Missense Variants.
Genomics Proteomics Bioinformatics
April 2023
Next-generation sequencing technologies both boost the discovery of variants in the human genome and exacerbate the challenges of pathogenic variant identification. In this study, we developed Pathogenicity Prediction Tool for missense variants (mvPPT), a highly sensitive and accurate missense variant classifier based on gradient boosting. mvPPT adopts high-confidence training sets with a wide spectrum of variant profiles, and extracts three categories of features, including scores from existing prediction tools, frequencies (allele frequencies, amino acid frequencies, and genotype frequencies), and genomic context.
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