Publications by authors named "Shi-Yuan Tao"
Rapid eye movement (REM) sleep disturbances are prevalent in various psychiatric disorders. However, the neural circuits that regulate REM sleep remain poorly understood. Here, we found that in male mice, optogenetic activation of rostromedial tegmental nucleus (RMTg) GABAergic neurons immediately converted REM sleep to arousal and then initiated non-REM (NREM) sleep.
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- The rostromedial tegmental area (RMTg) plays a key role in behaviors like sleep and addiction, but the activity patterns of GABAergic neurons in this area were not fully understood before this study.
- Researchers used a specialized method involving rabies viruses to identify and map the brain regions that send signals to RMTg GABAergic neurons in mice, discovering 71 projection regions.
- The study found that a significant majority of input neurons originated from nearby areas, with key regions identified as the lateral hypothalamus and the pontine reticular nucleus, revealing intricate connections that help the RMTg GABAergic neurons process various types of information.