Publications by authors named "Shi-Yu Liu"

Yi-Qi-Yang-Yin Decoction (YQYY), a traditional Chinese medicine (TCM) formula, has been used to treat diabetic retinopathy (DR), yet its precise mechanisms of action remain poorly understood. In this study, two distinct diabetic models, namely spontaneous type 2 diabetic db/db mice and streptozotocin (STZ)-induced type 1 diabetic rats, were employed to assess the efficacy of YQYY in ameliorating DR. Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was employed to identify the chemical composition of YQYY in mouse serum.

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Acylaminoacyl-peptide hydrolase (APEH), a serine peptidase that belongs to the prolyl oligopeptidase (POP) family, catalyzes removal of N-terminal acetylated amino acid residues from peptides. As a key regulator of protein N-terminal acetylation, APEH was involved in many important physiological processes while its aberrant expression was correlated with progression of various diseases such as inflammation, diabetics, Alzheimer's disease (AD), and cancers. However, while emerging attention has been attracted in APEH-related disease diagnosis and drug discovery, the mechanisms behind APEH and related disease progression are still unclear; thus, further investigating the physiological role and function of APEH is of great importance.

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Background: Resistance to senescence in retinal pigment epithelial (RPE) cells can delay the progression of age-related macular degeneration (AMD). However, the mechanisms underlying RPE cell senescence remain inadequately understood, and effective therapeutic strategies are lacking. While astragaloside IV (Ast) has demonstrated anti-aging properties, its specific effects on RPE cell senescence and potential mechanisms are not yet fully clarified.

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Diabetic cardiomyopathy is a unique cardiomyopathy that is common in diabetic patients, and it is also a diabetic complication for which no effective treatment is currently available. Moreover, relevant studies have revealed that a link exists between type 2 diabetes and heart failure and that abnormal thickening of EAT is inextricably linked to the development of diabetic heart failure. Numerous clinical studies have demonstrated that EAT is implicated in the pathophysiologic process of diabetic myocardial disease.

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As the global population ages, the incidence and prevalence of Alzheimer's disease (AD) continues to rise, posing a serious threat to human health. Butyrylcholinesterase (BChE), which is overexpressed in the brains of patients with AD, is a potential drug target and biomarker. However, the molecular mechanism underlying BChE's role in the AD process remains unclear.

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Article Synopsis
  • The study investigates how body composition, age, and tumor staging affect the prognosis of gastric cancer, using machine learning techniques to create prediction models.
  • It analyzed data from 1,132 gastric cancer patients, revealing significant factors impacting recurrence-free survival (RFS) and overall survival (OS), including age, tumor staging, and muscle characteristics.
  • The results showed distinct prognostic subgroups based on these factors, suggesting that combining these analytical methods can improve treatment planning and clinical decisions for gastric cancer patients.
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  • High ionic conductivity solid-state electrolytes, like LiYBr and LiLaBr, are crucial for efficient solid-state lithium-ion batteries.
  • Using simulations, researchers discovered optimal crystal structures and uniform lithium ion distributions in these materials, with notable electrochemical stability windows (2.64 V for LiYBr and 2.57 V for LiLaBr).
  • The study indicated that LiYBr and LiLaBr possess significant room temperature conductivity (3.9 mS/cm and higher), with low activation energies (0.26 eV and 0.24 eV respectively), suggesting their potential in enhancing solid-state battery performance.
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Epithelial mesenchymal transition (EMT) is a critical process implicated in the pathogenesis of retinal fibrosis and the exacerbation of diabetic retinopathy (DR) within retinal pigment epithelium (RPE) cells. Apigenin (AP), a potential dietary supplement for managing diabetes and its associated complications, has demonstrated inhibitory effects on EMT in various diseases. However, the specific impact and underlying mechanisms of AP on EMT in RPE cells remain poorly understood.

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Background: The alleviating effect of paeoniflorin (Pae) on liver fibrosis has been established; however, the molecular mechanism and specific target(s) underlying this effect remain elusive.

Purpose: This study was to investigate the molecular mechanism underlying the regulatory effect of Pae on hepatic stellate cells (HSCs) activation in liver fibrosis, with a specific focus on the role of Pae in modulating histone methylation modifications.

Methods: The therapeutic effect of Pae was evaluated by establishing in vivo and in vitro models of carbon tetrachloride (CCl)-induced mice and transforming growth factor β (TGF-β)-induced LX-2 cells, respectively.

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Gastroscopy, a critical tool for the diagnosis of upper gastrointestinal diseases, has recently incorporated artificial intelligence (AI) technology to alleviate the challenges involved in endoscopic diagnosis of some lesions, thereby enhancing diagnostic accuracy. This narrative review covers the current status of research concerning various applications of AI technology to gastroscopy, then discusses future research directions. By providing this review, we hope to promote the integration of gastroscopy and AI technology, with long-term clinical applications that can assist patients.

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  • The study uses density-functional calculations and thermodynamics to analyze the stability and mechanical properties of 15 quaternary high-entropy metal disilicides made from silicon and four transition metals.
  • A three-dimensional diagram was created to assess the thermodynamic stability, indicating that 14 of the 15 metal disilicides can be formed favorably, except for TiZrHfVSi.
  • The predicted metal disilicides have better mechanical properties and higher melting points compared to traditional single-metal disilicides, with TiHfNbTaSi already successfully synthesized.
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Background: Soothing the liver and regulating qi is one of the core ideas of traditional Chinese medicine (TCM) in the treatment of fatty liver. Si-Ni-San (SNS) is a well-known herbal formula in TCM for liver soothing and qi regulation in fatty liver treatment. However, its efficacy lacks modern scientific evidence.

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The mechanism of melting is significant, as it links the structure and dynamics between crystal and liquid. In two dimensions, the crystal could first melt into a hexatic liquid before finally reaching a disordered liquid. However, such a hexatic liquid phase is unstable in three dimensions, and melting is recognized as a one-step process.

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With the development of imaging technology and artificial intelligence, hyperspectral imaging technology provides a fast, non-destructive, intelligent, and precise new method for the analysis of Chinese materia medica(CMM). This paper summarized the methods and applications of hyperspectral imaging technology combined with intelligent analysis technology in the field of CMM in recent years, focusing on the acquisition and preprocessing of hyperspectral data, intelligent analysis methods of hyperspectral data, and practical cases of these technologies in the field of CMM. Hyperspectral data of CMM can provide spectral information with nanometer-level resolution and rich spatial texture information simultaneously.

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Hydrogenation-induced modification of magnetic properties has been widely studied. A Mg spacer layer with high hydrogen storage stability was clamped in a Pd/Co/Mg/Fe multilayer structure to enhance its hydrogen storage stability and explore the structure's magneto-transport properties. After 1 bar hydrogen exposure, the formation of a stable MgH phase was demonstrated in an ambient environment at room temperature through X-ray diffraction.

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  • Perovskite solar cells made from hybrid organic-inorganic lead halide materials have gained popularity due to their high efficiency, but issues with toxic lead and material stability pose challenges for their use.
  • Researchers used density functional theory to investigate ten lead-free perovskite materials that incorporate cesium, tin, and various halogens (Cl, Br, I).
  • The study revealed that the types and amounts of halogen atoms affect the stability and properties of these materials, with specific lead-free combinations identified as suitable candidates for solar cell applications.
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Intrinsic relaxation processes determine the crucial properties of glass, yet their underlying mechanisms are far from well understood. The brand-new glass-forming metal-organic frameworks (MOFs) provide desirable opportunities for looking inside glass relaxation, especially the secondary β-relaxation phenomenon and mechanism. For a representative zeolitic imidazolate framework-62 (ZIF-62) glass, reliable and fine powder mechanical spectroscopy was performed based on home-made mountings combined with a commercial dynamical mechanical analyzer.

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Neuronal apoptosis has been well-recognized as a critical mediator in the pathogenesis of depressive disorders. Tissue kallikrein-related peptidase 8 (KLK8), a trypsin-like serine protease, has been implicated in the pathogenesis of several psychiatric disorders. The present study aimed to explore the potential function of KLK8 in hippocampal neuronal cell apoptosis associated with depressive disorders in rodent models of chronic unpredictable mild stress (CUMS)-induced depression.

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Precipitation and landscape pattern are two main factors affecting runoff process of the watershed. Understanding their runoff effect is of great significance to water resources management and ecological construction of watershed. Based on the data of precipitation, runoff, and land use from 1958 to 2020, we analyzed the characteristics of precipitation, landscape pattern and runoff in Lianshui watershed in red soil hilly area of southern Jiangxi Pro-vince, established the relationship between precipitation, landscape pattern and annual runoff, flood runoff, low runoff, respectively.

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Chymotrypsin, an extensively known proteolytic enzyme, plays a substantial role in maintaining physiological functions, including protein digestion, immune response, and tissue repair. To date, intense attention has been focused on the invention of efficient and sensitive chemical tools for chymotrypsin activity measurement. Among them, the "nonpeptide"-based chymotrypsin probe design strategy utilizing the esterase activity of chymotrypsin has been well-developed due to its low cost and high atom-economy feature.

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Early diagnosis of cancer is an efficient strategy to prevent tumor progression and improve the survival rate of patients. However, to discovery of reliable tumor-specific biomarkers remains a great challenge. Leukotriene A4 hydrolase (LTAH) is a bifunctional zinc metalloenzyme with epoxide hydrolase activity and aminopeptidase activity, which plays important roles in allergic and inflammatory reactions and showed strong relevance with carcinoma progression.

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Baseflow is an important part of water resources. Exploring the characteristics of baseflow and its response to precipitation is of great significance to optimize the partition of water resources. Based on the data of daily precipitation and runoff from 1982 to 2019 in Jiuqushui watershed, we analyzed the characteristics of baseflow change, investigated the time lag effect of baseflow on precipitation, and calculated the contribution rate of precipitation to baseflow change by using digital filtering method, cross wavelet transform method, and slope change ratio of accumulative quantity method.

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Metabolic-associated fatty liver disease (MAFLD) is a growing global problem associated with increasing obesity prevalence. Lifestyle modifications are currently recommended, including weight reduction, exercise, and diet control. This study evaluated the short-term effect of lifestyle modifications on transient elastography (TE) values in an obese population with MAFLD.

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Carboxylesterase 2 (CES2) is a serine-type hydrolase that plays important roles in xenobiotic detoxification and lipid metabolism. Its abnormal expression is highly associated with diseases such as diabetes and carcinoma. To date, intense attention has been attracted to CES2 targeted drug discovery and disease diagnosis.

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Thyroid cancer (TC) has increased globally, with a prominent increase in small, papillary thyroid cancers. PEST-containing nuclear protein (PCNP), a nuclear protein, has been found to be associated with human cancers in recent years. However, the role and molecular mechanism of PCNP in thyroid cancer remain underexplored.

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