Combined ANFIS and numerical methods to reveal the mass transfer mechanism of ultrasound-enhanced extraction of proteins from millet.

Millet protein, as a promising plant-based protein substitute source, is an excellent basis for essential amino acids compared to commonly consumed staple grains. Compared with the traditional extraction process, ultrasound has been used to enhance the extraction efficiency of various plant-based proteins. To reveal the mechanism of ultrasound-enhanced extraction of proteins, adaptive neuro-fuzzy inference system (ANFIS) algorithm and numerical simulation based on Fick's law were applied to illustrate the mass transfer behavior of millet proteins under different ultrasonic conditions including solid-liquid ratios (S/L ratios), pH and acoustic energy density levels (AED).

Magnetically Enhanced Oxygen Evolution Reaction in Mild Alkaline Electrolytes by Building Catalysts on Magnetic Frame.

Under large current densities, the excessive hydroxide ion (OH) consumption hampers alkaline water splitting involving the oxygen evolution reaction (OER). High OH concentration (≈30 wt.%) is often used to enhance the catalytic activity of OER, but it also leads to higher corrosion in practical systems.

Protective Effects of Statins on Limb and Cardiovascular Outcomes in Patients with Peripheral Artery Disease and End-Stage Renal Disease.

Background: Previous studies have reported that statins have inconsistent and marginal cardiovascular (CV) benefits in patients with end-stage renal disease (ESRD). However, whether statins play a secondary preventive role in patients with peripheral artery disease (PAD) and ESRD remains unclear.

Objectives: This study aimed to compare the long-term clinical outcomes between statin users and nonusers with PAD and ESRD.

Corrigendum: Characterization of structure and antioxidant activity of polysaccharides from sesame seed hull.

[This corrects the article DOI: 10.3389/fnut.2022.

Bio-derived FeNi alloy confined in N-doped carbon nanosheets as efficient air electrodes for Zn-air battery.

It is imperative to design and manufacture electrocatalysts towards oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) for popularization of rechargeable Zn-air batteries. Herein, FeNi alloy confined in N-doped carbon nanosheets (FeNi@NCSs) was harvested via a facile complexation-pyrolysis strategy from the mixture of guanine and metal chlorides. After strictly exploring the pyrolysis temperature and metal types, the resulted FeNi@NCSs showed greatly improved performances on both the ORR (onset potential of 0.

Coordination regulated pyrolysis synthesis of ultrafine FeNi/(FeNi)S nanoclusters/nitrogen, sulfur-codoped graphitic carbon nanosheets as efficient bifunctional oxygen electrocatalysts.

Design of advanced carbon nanomaterials with high-efficiency oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) activities is still imperative yet challenging for searching green and renewable energies. Herein, we synthesized ultrafine FeNi/(FeNi)S nanoclusters encapsulated in nitrogen, sulfur-codoped graphitic carbon nanosheets (FeNi/(FeNi)S/N,S-CNS) by coordination regulated pyrolyzing the mixture of the metal precursors, dithizone and g-CN at 800 °C. The as-prepared FeNi/(FeNi)S/N,S-CNS exhibited distinct electrocatalytic activity and stability for the ORR with positive onset (E) and half-wave (E) potentials (E = 0.

FeCo/FeCoP encapsulated in N, Mn-codoped three-dimensional fluffy porous carbon nanostructures as highly efficient bifunctional electrocatalyst with multi-components synergistic catalysis for ultra-stable rechargeable Zn-air batteries.

Currently, it is critical but a tricky point to develop economical, high-efficiency, and durable non-precious metal electrocatalysts towards oxygen reduction and oxygen evolution reaction (ORR/OER) in rechargeable Zn-air batteries. Herein, N, Mn-codoped three-dimensional (3D) fluffy porous carbon nanostructures encapsulating FeCo/FeCoP alloyed nanoparticles (FeCo/FeCoP@NMn-CNS) are prepared by one-step pyrolysis of the metal precursors and polyinosinic acid. The optimized hybrid nanocomposite (obtained at 800 °C, named as FeCo/FeCoP@NMn-CNS-800) exhibits outstanding catalytic performance in the alkaline electrolyte with a half-wave potential (E) of 0.

CoFe alloy embedded in N-doped carbon nanotubes derived from triamterene as a highly efficient and durable electrocatalyst beyond commercial Pt/C for oxygen reduction.

For development of green and sustainable energy, it is of importance to search highly efficient and low-cost electrocatalysts of oxygen reduction reaction (ORR) in energy conversion devices. Herein, CoFe alloyed nanocrystals embedded in N-doped bamboo-like carbon nanotubes (CoFe@NCNTs) were facilely synthetized by one-step co-pyrolysis with the mixture of triamterene, metal chlorides and graphitic carbon nitride (g-CN). The resultant CoFe@NCNTs exhibited excellent ORR activity with the positive shifts in the onset potential (E = 0.

Supplementation with Tetrahydrocurcumin Enhances the Therapeutic Effects of Dexamethasone in a Murine Model of Allergic Asthma.

Background: Tetrahydrocurcumin (THC) is the major active metabolite of curcumin, which is a dietary factor derived from Curcuma species. Our previous study demonstrated a significant beneficial effect of THC in mice with allergic asthma. Glucocorticosteroids (GCs) are commonly used drugs in asthma.

Qingxin Kaiqiao Recipe Improves Cognitive Performance, Inhibits Apoptosis, and Reduces Pathological Deposits in APP/PS1 Double Transgenic Mice via the PI3K/Akt Pathway.

The traditional Chinese medicine of Qingxin Kaiqiao Recipe (QKR) is effective in the treatment of Alzheimer's disease (AD). This study aims to investigate whether QKR improves the cognitive ability and takes neuroprotective effect on APP/PS1 double transgenic mice via the PI3K/Akt pathway. APP/PS1 double transgenic mice were randomly divided into a model, donepezil-treated, or QKR-treated group (L-QKR: 4.

Constituents from the Seeds of L.

Three new isoflavone glucosides, kudonol A-C (-), two new ester derivatives of phenylpropanoid, kudolignan A and B (-) and five known compounds, (-)-maackiain (), neoliquiritin (), methyl 4-coumarate (), methyl ferulate () and (+)-wikstromol (), were isolated from an extract of dried seeds of the traditional Chinese medicinal plant L. Their structures were established by NMR and HRESIMS data analyses. The monosaccharide part's configuration of isoflavone glucosides was confirmed by acid hydrolysis and analyzed by a JAsco OR-4090 chiral detector, comparing it to standard substance D-glucose.

Effects of neurostimulation for advanced Parkinson's disease patients on motor symptoms: A multiple-treatments meta-analysas of randomized controlled trials.

Deep brain stimulation (DBS) is the surgical procedure of choice for patients with advanced Parkinson disease (PD). We aim to evaluate the efficacy of GPi (globus pallidus internus), STN (subthalamic nucleus)-DBS and medical therapy for PD. We conducted a systematic review and multiple-treatments meta-analysis to investigate the efficacy of neurostimulation and medical therapy for PD patients.

Repetitive transcranial magnetic stimulation (rTMS) for the treatment of depression in Parkinson disease: a meta-analysis of randomized controlled clinical trials.

The objective of this meta-analysis was to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) for the treatment of depression in patients with Parkinson disease in order to arrive at qualitative and quantitative conclusions about the efficacy of rTMS. We included randomized controlled trials examining the effects of rTMS compared with sham-rTMS or selective serotonin re-uptake inhibitors (SSRIs). The quality of included studies was strictly evaluated.

Levodopa alone compared with levodopa-sparing therapy as initial treatment for Parkinson's disease: a meta-analysis.

To assess the long-term use of L-dopa alone vs L-dopa-sparing therapy, as initial treatment, provides the most efficient long-term control of symptoms and best quality of life for people with early Parkinson's disease (PD). PubMed; Google scholar; Cochrane Central Register of Controlled Trials and the Web of Science were searched for randomised, placebo-controlled trials (RCTs) on L-dopa alone and L-dopa sparing as initial treatment in early PD patients. We used a random effects model rather than a fixed effects model because of this takes into account heterogeneity between multi-studies.

Plasma membrane depolarization and Na,K-ATPase impairment induced by mitochondrial toxins augment leukemia cell apoptosis via a novel mitochondrial amplification mechanism.

Na,K-ATPase is a ubiquitous transmembrane protein that regulates and maintains the intracellular Na(+) and K(+) gradient necessary for cell homeostasis. Recently, the importance of this pump in external stimuli-induced leukemia cell apoptosis has been increasingly appreciated, however, the exact role of Na,K-ATPase in mitochondrial apoptotic pathway still remains little understood. In this study, we found mitochondrial toxin rotenone caused a rapid mitochondrial membrane potential (MMP) collapse in Jurkat cells followed by plasma membrane depolarization (PMP).