Publications by authors named "Shi-Yang Guan"
Article Synopsis
- Autoimmune diseases result from both unchangeable factors like genetics and gender, and changeable factors such as lifestyle and environmental influences; this study explores how modifiable factors have affected the global burden of these diseases from 1990 to 2021.
- The research used data from the Global Burden of Diseases study, focusing on trends in disability-adjusted life-years (DALYs) and examining disparities between different socio-demographic groups using statistical methods.
- Findings indicate an increase in DALYs for type 1 diabetes due to high temperatures, especially in high socio-demographic index (SDI) countries, while other autoimmune diseases show declining trends, highlighting inequalities based on socio-economic status.
Aim: This study aims to elucidate the impact of childhood sexual abuse (CSA) on major depressive disorder (MDD) and alcohol use disorder (AUD) globally, regionally, and nationally, informing targeted public health interventions and policy.
Methods: Using data from the Global Burden of Disease (GBD) Study 2019, we assessed the impact of CSA on MDD and AUD, analyzing disability-adjusted life years (DALYs) per 100,000 population. Our analysis included age, sex, geographic locations, temporal trends in age-standardized rates (ASR), and examined the relationship between the social development index (SDI) and the burden of these disorders.
Objective: Chronic kidney disease (CKD) poses a major global health burden. Early CKD risk prediction enables timely interventions, but conventional models have limited accuracy. Machine learning (ML) enhances prediction, but interpretability is needed to support clinical usage with both in diagnostic and decision-making.
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- Previous studies suggested a link between inflammatory cytokines and tuberculosis (TB), but this research aimed to clarify that relationship using Mendelian randomization analyses with data from genetic studies and TB cases.
- The analysis found a positive causal relationship between interleukin-7 levels and TB risk, while negative associations were identified for several factors, including macrophage inflammatory protein 1 alpha and interleukins 2 and 2 receptor alpha.
- This study enhances our understanding of TB mechanisms and may lead to new ways to identify potential treatments or interventions.
Inflammatory cytokines disturbance is the main result of immune dysregulation, which is widely described in major depressive disorder (MDD). However, the potential causal relationship between these two factors has not been discovered. Therefore, the purpose of this study was to investigate the causal relationship between inflammatory cytokines and MDD risk by using the two-sample Mendelian randomization (MR) analysis.
View Article and Find Full Text PDFBackground: Current studies on musculoskeletal (MSK) disorders mainly focus on the elderly, while adolescents and young adults (AYAs) are often neglected despite their unique epidemiology, healthcare needs and societal implications. To bridge this gap, we evaluated the global burden and temporal trends of MSK disorders among AYAs from 1990 to 2019, as well as their common categories and main risk factors.
Methods: Data on the global burden and risk factors of MSK disorders were obtained from the Global Burden of Diseases study 2019.
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.
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- Pentraxin 3 (PTX3) is a molecule that reflects disease activity in rheumatoid arthritis (RA) and serves as a potential therapeutic target; this study aims to assess circulating PTX3 levels in RA patients and factors influencing them.* -
- A meta-analysis of 21 studies found that RA patients have significantly higher circulating PTX3 levels compared to healthy individuals, especially in younger patients and those with higher disease activity scores.* -
- Results indicate that specific factors, such as age and disease duration, affect PTX3 levels; however, older RA patients with lower disease activity showed no significant changes in PTX3 levels.*
B7-H3 as a newly identified costimulatory molecule that belongs to B7 ligand family, is broadly expressed in both lymphoid and non-lymphoid tissues. The overexpression of B7-H3 has been verified to be correlated with the poor prognosis and poor clinical outcome of several human cancers. In recent years, researchers reveal that B7-H3 is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), Sjögren's syndrome (SS), ankylosing spondylitis (AS), etc.
View Article and Find Full Text PDFAims: Several studies have reported a potential association between prostate volume (PV) and prostate disease. Here, we classified the risk factors for PV among benign prostatic hyperplasia (BPH) patients.
Methods: In all, 4293 BPH patients with available clinical information were enrolled.
Article Synopsis
- * Results showed that SLE patients had significantly higher PTX3 levels compared to controls, with a pooled effect size indicating this difference.
- * Subgroup analyses revealed that factors like age, ethnicity, disease activity, and sample type influenced PTX3 levels in SLE patients.
Article Synopsis
- - The study investigates the levels of 25-hydroxyvitamin D (25(OH)D) in patients with systemic lupus erythematosus (SLE) to determine its association with SLE risk and severity.
- - A meta-analysis of 19 articles reveals that SLE patients have significantly lower circulating 25(OH)D levels compared to healthy individuals, with certain subgroups (e.g., those with higher disease activity or no vitamin D supplementation) showing more pronounced deficiencies.
- - The analysis indicates that vitamin D status can influence SLE risk, where both deficiency and insufficiency increase SLE risk significantly, while sufficient levels appear to slightly mitigate the risk.
Purpose: Prostatic calculi (PCal) are commonly present with prostate disease; we aim to map the incidence and associated clinical risk factors of PCal in Han Chinese.
Material And Methods: We retrospectively selected men who sought a medical check-up in 2018. Basic clinical items, including age, weight, height, prostate specific antigen (PSA), uric acid (UA), fasting blood glucose (FBG), urinalysis results, and transabdominal prostate ultrasound, were recorded.
Introduction: Several published results have established variations in respect to plasma/serum macrophage migration inhibitory factor (MIF) levels and gene polymorphisms with systemic lupus erythematosus (SLE). This study gave a more concise estimation on the MIF levels for SLE patients and established the association between MIF polymorphisms and SLE.
Material And Methods: All articles were searched from PubMed, Embase, Web of Science, Wan-Fang, Chinese Biological Medical Literature, and China National Knowledge Infrastructure up to 6 October 2017, with no language restriction.
Identify long non-coding RNAs (lncRNAs) that might serve as biomarkers for systemic lupus erythematosus (SLE) and explore the biological functions of the identified lncRNAs. In the screening phase, we examined the lncRNA expression profile of plasma samples from 24 patients with SLE and 12 healthy controls (HCs) using lncRNA microarray with pooled samples. The candidate lncRNAs were verified in individual samples by quantitative real-time (qRT)-PCR.
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- * A total of 490 SLE patients and 489 healthy controls were examined for seven specific SNPs of the IL-35 encoding gene to see if there were links to SLE susceptibility and symptoms.
- * Findings revealed that the rs4740 polymorphism is significantly linked to renal and hematological disorders in SLE patients, but no overall associations between the SNPs and SLE risk or plasma IL-35 levels were found.
Article Synopsis
- The study evaluated the link between two SNPs of the GPR65 gene (rs68177277 and rs11624293) and the risk of developing ankylosing spondylitis (AS) in a Chinese Han population.
- A total of 673 AS patients and 679 healthy controls were analyzed, revealing significant differences in the genotype distribution of rs11624293 between the two groups but not for rs68177277.
- The findings suggest that the rs11624293 SNP is linked to both the susceptibility and severity of AS, particularly influencing disease activity in patients with lower levels of severity.
Cardiovascular (CV) risk in type 1 diabetes mellitus (T1DM) is increased. In this study, we evaluated the differences in major markers of CV risk between patients with T1DM and healthy controls by a systematic review and meta-analysis. Literature from PubMed, EMBASE, and The Cochrane Library comparing CV risk markers between patients with T1DM and controls was obtained.
View Article and Find Full Text PDFBackground And Aims: Matrix metalloproteinase-9 (MMP-9) is closely related to the pathogenesis of autoimmune diseases, especially Systemic Lupus Erythematosus (SLE). However, published works about the circulating MMP-9 levels in SLE are contradictory. A meta-analysis was performed to estimate circulating MMP- 9 levels in SLE patients more accurately and explore its related influencing factors.
View Article and Find Full Text PDFCurrently, many studies have focused on the possibility of using mean platelet volume (MPV) as a biomarker for disease activity in patients with systemic lupus erythematosus (SLE). To derive a more accurate estimation, a meta-analysis was conducted. Embase, PubMed, The Cochrane Library database and several Chinese databases (up to Nov 1 2017) were used to acquire published literatures on association of MPV levels with disease activity in SLE patients.
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- - The study investigates the connection between pulmonary hypertension (PH) and systemic lupus erythematosus (SLE), aiming to provide a clearer estimation of PH prevalence in SLE patients through a meta-analysis of existing literature.
- - After reviewing 1366 articles, the analysis included 23 studies, finding an overall PH prevalence of 8% among SLE patients, with no signs of publication bias affecting the results.
- - Results indicated that PH prevalence varies significantly based on factors like gender, age, geographic region, publication year, and diagnostic methods used.
Article Synopsis
- - The study examines the use of procalcitonin (PCT) as a marker to differentiate between flare-ups of systemic lupus erythematosus (SLE) and infections, finding mixed results in existing literature.
- - A meta-analysis was conducted that included eight studies, analyzing over 400 SLE patients, which revealed no significant difference in PCT levels between those experiencing SLE flare and those with infections overall.
- - However, a notable finding from subgroup analysis indicates that Asian SLE patients with infections had significantly higher PCT levels compared to those with SLE flare-ups, suggesting potential differences based on population demographics.
Hypoxia-inducible factor-1α: a promising therapeutic target for autoimmune diseases.
Expert Opin Ther Targets
July 2017
Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in both innate and adaptive immunity. Emerging evidence indicates that HIF-1α is associated with the inflammation and pathologic activities of autoimmune diseases. Areas covered: Considering that the types of autoimmune diseases are complicated and various, this review aims to cover the typical kinds of autoimmune diseases, discuss the molecular mechanisms, biological functions and expression of HIF-1α in these diseases, and further explore its therapeutic potential.
View Article and Find Full Text PDFBACKGROUND To explore the significance of short message service (SMS) on the management of pulmonary tuberculosis (TB) patients in reinforcing the treatment adherence and health awareness, and provide scientific evidences for popularizing this model and formulating related polices and measures. MATERIAL AND METHODS Six counties (districts) were selected by stratified cluster sampling method, and randomly divided into control group and intervention group. Pulmonary TB patients eligible to the study criteria were included in the study.
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