Publications by authors named "Shi-Ya Xie"
Article Synopsis
- Cervical cancer (CC) affects women globally, and while extensive research has been conducted on its development at various biological levels, there has been limited focus on post-translational modifications (PTMs) in understanding CC progression.
- This study compared PTM levels between normal cervical tissues and CC tissues, identifying that pan-acetylation was significantly decreased in cancer samples, while the acetylation of PARP1 at K119 was notably increased.
- Overexpressing PARP1-WT reduced cancer cell proliferation and impacted specific signaling pathways, particularly decreasing p-ERK1/2 levels, indicating that the acetylation of PARP1 at K119 plays a crucial role in regulating the progression of cervical cancer.
Microtubule-severing enzymes (MTSEs) play important roles in mitosis and meiosis of the primitive organisms. However, no studies have assessed their roles in mammalian meiosis of females, whose abnormality accounts for over 80% of the cases of gamete-originated human reproductive disease. In the current study, we reported that katanin-like 2 (KL2) was the only MTSE concentrating at chromosomes.
View Article and Find Full Text PDFMicrotubule-severing proteins (MTSPs), are a family of proteins which use adenosine triphosphate to sever microtubules. MTSPs have been shown to play an important role in multiple microtubule-involved cellular processes. One member of this family, fidgetin ( ), is also involved in male fertility; however, no studies have explored its roles in female fertility.
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