Aqueous Extract of Whitmania Pigra Whitman Alleviates Thrombus Burden Via Sirtuin 1/NF-κB Pathway.

Background: Whitmania pigra Whitman (W pigra), a traditional Chinese medicine, has functions of breaking stagnant and eliminating blood stasis. The aim of this study was to investigate the underlying mechanism of W pigra against deep vein thrombosis (DVT).

Methods: A rat model of DVT induced by inferior vena cava stenosis was successfully established.

Enhancement of the oral bioavailability of breviscapine by nanoemulsions drug delivery system.

Aim to design an effective breviscapine nanoscale drug delivery system to realize the improvement of its oral bioavailability. Based on the investigations of the stabilities in the gastrointestinal tract (GIT), permeation and efflux across the cell membrane, the breviscapine nanoemulsion (NE) was formulated and evaluated in vitro and in vivo. The globule size and polydispersity index of the NE was 45.

Characteristics and evaluation of an injectable clarithromycin lipid-based complex in vitro and in vivo.

The purpose of this paper is to prepare a less-irritating and lipid-based clarithromycin complex (LCC) by the route of intravenous administration qualified with high drug-loading and fine particle size. The LCC was prepared by the injection of organic solvent phase (containing clarithromycin, sodium cholesterol sulfate and phospholipid at a molar ratio of 1:1:1.5) into the Tris buffer solution (0.

Evaluation of tetrandrine sustained release calcium alginate gel beads in vitro and in vivo.

An approach for the preparation of tetrandrine sustained release calcium alginate gel beads was described. In vitro the release of tetrandrine from sustained release dosage forms went on a time of 12 hours which fitted non-Fickian diffusion with matrix erosion significantly. In vivo the plasma concentration of tetrandrine extended preparation given in dogs reached Cmax 2.