Publications by authors named "Shi-Shuang Cui"
Alzheimer's disease (AD) is the most common form of dementia and numerous studies reported a higher prevalence and incidence of AD among women. Although women have longer lifetime, longevity does not wholly explain the higher frequency and lifetime risk in women. It is important to understand sex differences in AD pathophysiology and pathogenesis, which could provide foundation for future clinical AD research.
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- Genetic factors significantly influence the risk and progression of Parkinson's disease (PD), but little research has been done on how these factors affect progression specifically in Chinese patients.
- The study analyzed genetic variants (single nucleotide polymorphisms) in a cohort of Chinese PD patients, comparing results with a separate PPMI cohort, and assessed progression through various scales using advanced statistical models.
- Findings indicated that the rs1799836 variant is linked to cognitive decline and overall symptom progression in Chinese patients, while another variant, rs12456492, is associated with motor symptom progression, suggesting ethnic variations in these genetic influences on PD.
Mechanisms of motor symptom improvement by long-term Tai Chi training in Parkinson's disease patients.
Transl Neurodegener
February 2022
Background: Tai Chi has been shown to improve motor symptoms in Parkinson's disease (PD), but its long-term effects and the related mechanisms remain to be elucidated. In this study, we investigated the effects of long-term Tai Chi training on motor symptoms in PD and the underlying mechanisms.
Methods: Ninety-five early-stage PD patients were enrolled and randomly divided into Tai Chi (n = 32), brisk walking (n = 31) and no-exercise (n = 32) groups.
Article Synopsis
- The study investigates the differences in clinical features between male and female Parkinson's disease (PD) patients who carry the LRRK2 G2385R genetic variant.
- It analyzes data from 613 PD patients, focusing on cognitive impairment in males and autonomic dysfunction in females, showing that carriers of the variant have a lower risk of these conditions.
- Results indicate that females without the G2385R variant may have lower risks for daily living impairment and excessive daytime sleepiness but a higher risk for mood disorders compared to males.
Background: Progressive supranuclear palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aimed to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living.
Method: All patients recruited fulfilled the movement disorder society (MDS) clinical diagnostic criteria for PSP (MDS-PSP criteria) for probable and possible PSP with median 12 years.
Hyposmia is one of the most important clinical markers of Parkinson's disease (PD) with a prevalence ranging from 50 to 96% of PD patients. A significant association was found between hyposmia and cognitive impairment of PD. However, there were no reports of event-related potentials (ERP) performance in PD patients with and without hyposmia for cognitive functions assessment.
View Article and Find Full Text PDFObjective: Lymphocyte activation gene-3 (LAG-3) could mediate pathological α-synuclein transmission in neurodegeneration and may be involved in the pathogenesis of Parkinson's disease (PD). The aim of the present study was to explore soluble LAG-3 (sLAG-3) as a potential diagnostic biomarker for PD.
Methods: Serum sLAG-3 concentrations were measured by a quantitative ELISA for patients with PD, essential tremor (ET) and age- and sex-matched controls.
Background: The differential diagnosis of Parkinson's disease (PD) and multiple system atrophy (MSA) remains a challenge, especially in the early stage. Here, we assessed the value of transcranial sonography (TCS) to discriminate non-tremor dominant (non-TD) PD from MSA with predominant parkinsonism (MSA-P).
Methods: Eighty-six MSA-P patients and 147 age and gender-matched non-TD PD patients who had appropriate temporal acoustic bone windows were included in this study.
Background: It is debatable whether transcranial sonography (TCS) could be a biomarker for monitoring disease progression. Various phenotypes of Parkinson's disease (PD) may be a major reason contributing to the inconsistency.
Objective: We classified PD patients into different subtypes and evaluated the correlation between SN echogenicity and disease progression.
Article Synopsis
- Anxiety and depression are prevalent in Parkinson disease (PD), significantly affecting patients' quality of life, yet few studies have explored both general and PD-specific risk factors comprehensively.
- A study involving 403 PD patients identified that 11.17% experienced depression and 25.81% experienced anxiety, with various factors linked to these mental health issues, including marital status, motor function severity, and sleep quality.
- Specific risk factors for depression included having no partner and poorer sleep, while anxiety was associated with being female, having a poorer autonomic symptom profile, and larger echogenic areas in the substantia nigra.
Fatigue correlates with LRRK2 G2385R variant in Chinese Parkinson's disease patients.
Parkinsonism Relat Disord
November 2017
Introduction: Fatigue is common in patients with Parkinson's disease (PD). The leucine-rich repeat kinase 2 (LRRK2) G2385R variant predisposes individuals to develop PD in China. The aim of this study was to evaluate whether the LRRK2 G2385R variant is associated with fatigue in patients with PD.
View Article and Find Full Text PDFBackground: Huntington's disease (HD) is an autosomal dominant disorder, typically characterized by chorea due to a trinucleotide repeat expansion in the HTT gene, although the clinical manifestations of patients with juvenile HD (JHD) are atypical.
Case Presentation: A 17-year-old boy with initial presentation of tics attended our clinic and his DNA analysis demonstrated mutation in the HTT gene (49 CAG repeats). After treatment, his symptoms improved.
Objective: Fatigue is a common nonmotor symptom in Parkinson's disease (PD); however, the Parkinson's disease fatigue scale (PFS), which is designed to measure fatigue in PD, has not been validated in China. The aim of this study was to determine the validity and reliability of the Chinese version of the PFS in PD patients.
Methods: A total of 115 PD patients were evaluated at baseline and after 7 days.
. has already been nominated as PARK13 which may cause Parkinson's disease, though there are still discrepancies among these results. Recently, Gulsuner et al.
View Article and Find Full Text PDFBackground: Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the association between pRBD and Parkinson's disease (PD).
Methods: The validation study of RBD1Q-C included 32 Chinese participants (14 idiopathic RBD patients and 18 controls). All participants underwent a polysomnogram (PSG).