Publications by authors named "Shi-Ran Yu"
Background: Several clinical studies have suggested that the early administration of statins could reduce the risk of in-hospital mortality in acute myocardial infarction (AMI) patients. Recently, some studies have identified that stimulating lymphangiogenesis after AMI could improve cardiac function by reducing myocardial edema and inflammation. This study aimed to identify the effect of rosuvastatin on postinfarct lymphangiogenesis and to identify the underlying mechanism of this effect.
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- Recent studies highlight the lymphatic system's role in atherosclerosis, particularly its involvement in immune cell movement and cholesterol management, but understanding the underlying mechanisms is still limited.
- Researchers found that increased levels of microRNA-19b in endothelial microparticles (EMPs) are linked to a worsening of atherosclerosis and lymphatic system dysfunction in mice.
- The study suggests that miRNA-19b could damage lymphatic function by preventing important processes in lymphatic endothelial cells, potentially through downregulation of the TGF-β receptor, leading to issues at both early and later stages of atherosclerosis.
In our clinical practice, we recently found some patients with severe fulminant myocarditis (FM) who showed persistently elevated cardiac troponin (cTn) levels and "seemingly normal" B-type natriuretic peptide (BNP) level, and who subsequently progressed to poor outcomes. Indeed, this sounds contrary to conventional wisdom, but it is not an accidental phenomenon. Fulminant myocarditis is a rapidly progressive disease associated with high mortality.
View Article and Find Full Text PDFTo explore the potential targets underlying the effect of rosuvastatin on heart failure (HF) by utilizing a network pharmacology approach and experiments to identify the results. PharmMapper and other databases were mined for information relevant to the prediction of rosuvastatin targets and HF-related targets. Then, the rosuvastatin-HF target gene networks were created in Cytoscape software.
View Article and Find Full Text PDFPurpose: To perform a comprehensive meta-analysis of all available evidence on the efficacy and safety of catheter-based renal denervation for heart failure with reduced ejection fraction.
Methods: We searched English and Chinese databases and calculated the weighted mean difference or standardized mean difference and 95% confidence intervals to estimate the efficacy and safety of renal denervation for heart failure. All relevant studies were screened and a meta-analysis was conducted using Review Manager 5.