sFRP-4, a potential novel serum marker for chronic hepatitis B-related hepatocellular carcinoma.

Background: The current methods used for diagnosing hepatocellular carcinoma (HCC) are unsatisfactory. Here, we assessed the serum levels of secreted frizzled related protein 4 (sFRP-4) for diagnosing HCC in patients infected with chronic hepatitis B (CHB).

Methods: In 272 patients with CHB enrolled, 142 were patients with HCC.