Publications by authors named "Shi-Ping Yu"
The Golgi apparatus is one of the most important organelles in cells. Targeting and monitoring the morphology and structure of the Golgi apparatus are crucial and challenging. Aimed at the cysteine (Cys) receptor on the surface of the Golgi apparatus, ligand-directed carbon quantum dots (CQDs) were synthesized for Golgi apparatus-targeting imaging.
View Article and Find Full Text PDFPurpose: Parvovirus B19 (B19V) infection is a viral threat after kidney transplantation. It is mainly transmitted by close-contact inhalation of aerosolized viral particles. The risk of nosocomial spread of B19V in the transplantation ward is quite high.
View Article and Find Full Text PDFHigh pH tolerance of a chitosan-PAA nanosuspension for ophthalmic delivery of pilocarpine.
J Biomater Sci Polym Ed
May 2010
Article Synopsis
- Researchers developed nanoparticles made from chitosan (CS) and poly(acrylic acid) (PAA) to create an effective ophthalmic drug carrier.
- They used hydrogen peroxide to lower chitosan's molecular weight, enhancing its solubility and pH tolerance, which reached 7.1 under specific conditions (2 M concentration, 60°C for 2 hours).
- Both in vitro and in vivo tests indicated that these nanoparticles release the drug pilocarpine more effectively than standard eye drops, demonstrating their potential for improved ocular drug delivery.
Pilocarpine-loaded chitosan-PAA nanosuspension for ophthalmic delivery.
J Biomater Sci Polym Ed
March 2007
Chitosan-poly(acrylic acid) (CS-PAA) nanoparticles, to be used as ophthalmic drug carrier, were successfully prepared using template polymerization of acrylic acid (AA) in a chitosan solution. When the polymerization was done at 70 degrees C for 45 min with a CS/AA weight ratio of 1:1, the surface structure of the prepared nanoparticles was most stable with the smallest mean diameter (92.0 +/- 7.
View Article and Find Full Text PDFCharacterization of pilocarpine-loaded chitosan/Carbopol nanoparticles.
J Pharm Pharmacol
February 2006
Article Synopsis
- Patients using eye drops face challenges with frequent dosing and application difficulties, prompting the development of a long-lasting pilocarpine-loaded nanoparticle formulation using chitosan and Carbopol.
- The nanoparticles were characterized through various techniques, revealing a size of about 294 nm and demonstrating that the interaction between chitosan and Carbopol helps stabilize the formulation.
- In tests, the pilocarpine-loaded nanoparticles showed superior sustained-release effects compared to traditional formulations, with significant long-lasting effects observed in animal studies, indicating their potential for improved clinical application in ophthalmic treatments.
[Intraoperative 125I brachytherapy combined with chemotherapy for pancreatic cancer].
Zhonghua Zhong Liu Za Zhi
July 2004
Objective: To evaluate the efficacy, toxicity and survival of intraoperative 125I brachytherapy combined with chemotherapy for advanced pancreatic cancer.
Methods: Thirty-six patients with advanced pancreatic cancer were randomized to two groups: brachy-chemotherapy group (n = 18) and control group (n = 18). For the combined group, intraoperative 125I implantation and gemcitabine, 5-Fu were given.