Heterologous expression of the insect SVWC peptide WHIS1 inhibits invasion into A549 and HeLa epithelial cells.

(), a microbe commonly isolated from patients with vaginal tract infections, transforms from yeast to hyphae and produces many toxins, adhesins, and invasins, as well as biofilms resistant to antifungal antibiotic treatment. Effective agents against this pathogen are urgently needed. Antimicrobial peptides (AMPs) have been used to cure inflammation and infectious diseases.

Insufficient TRPM5 Mediates Lipotoxicity-induced Pancreatic β-cell Dysfunction.

Objective: While the reduction of transient receptor potential channel subfamily M member 5 (TRPM5) has been reported in islet cells from type 2 diabetic (T2D) mouse models, its role in lipotoxicity-induced pancreatic β-cell dysfunction remains unclear. This study aims to study its role.

Methods: Pancreas slices were prepared from mice subjected to a high-fat-diet (HFD) at different time points, and TRPM5 expression in the pancreatic β cells was examined using immunofluorescence staining.

A novel and green method for recycling of waste feather for down via flash explosion with supercritical carbon dioxide.

Millions of tons of feather are produced worldwide each year and considered as a solid waste owing to technical or cost constraints to provide valuable functional characteristics. In this study, a novel and ecofriendly method to recycle waste feather and obtain a type of explosion down via flash explosion with a supercritical fluid of carbon dioxide (SCF-CO) was developed for the first time. The effects of flash explosion parameters on the structures and properties of feather were explored by orthogonal experiments.

Using a facile experimental manipulation to fabricate and tune a polyoxometalate-cholesterol hybrid material.

In this work, we describe how the toluene and DMF addition order influences the gelation behaviors and supramolecular structures of a self-assembled polyoxometalate-cholesterol hybrid. Morphological studies of the dried xerogel samples were performed with transmission electron microscopy and atomic force microscopy, revealing that the order of solvent addition directed the self-assembly of polyoxometalate-cholesterol hybrids toward the formation of organogels with different supramolecular structures. In the case of organogel 1, which was formed by adding DMF dropwise into a hybrid-containing toluene solution, the characteristic organogel morphology contained a three-dimensional fibrous network structure.