Publications by authors named "Shi-Man Fu"
Article Synopsis
- Excess sodium intake contributes to hypertension through lymphatic dysfunction, with a focus on the role of the adenosine A2A receptor (A2AR) in lymphatic endothelial cells (LECs) during salt-induced hypertension.*
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- Mice with LEC-specific knockout of A2AR showed higher blood pressure and decreased lymphatic density, while A2AR activation using an agonist improved lymphatic density and lowered blood pressure, indicating its importance in regulating lymphatic function.*
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- The findings suggest A2AR-mediated signaling promotes lymphangiogenesis and sodium balance independently of VEGF, pointing to its potential as a therapeutic target for managing salt-sensitive hypertension.*
