Novel Stereoselective Syntheses of (+)-Streptol and (-)-1-Streptol Starting from Naturally Abundant (-)-Shikimic Acid.

Novel highly stereoselective syntheses of (+)-streptol and (-)-1--streptol starting from naturally abundant (-)-shikimic acid were described in this article. (-)-Shikimic acid was first converted to the common key intermediate by 11 steps in 40% yield. It was then converted to (+)-streptol by three steps in 72% yield, and it was also converted to (-)-1--streptol by one step in 90% yield.

Efficient and Highly Stereoselective Syntheses of (+)--Quercitol and (-)--Quercitol Starting from the Naturally Abundant (-)-Shikimic Acid.

Efficient and highly stereoselective syntheses of (+)--quercitol and (-)--quercitol starting from the naturally abundant (-)-shikimic acid were described in this article. (-)-Shikimic acid was first converted to the key intermediate by eight steps in 53% yield. It was then converted to (+)--quercitol by three steps in 78% yield and was also converted to (-)--quercitol by five steps in 63% yield.

Novel stereoselective syntheses of -octyl-β-valienamine (NOV) and -octyl-4--β-valienamine (NOEV) from (-)-shikimic acid.

-Octyl-β-valienamine (NOV) 1 and -octyl-4--β-valienamine (NOEV) 2 are potent chemical chaperone drug candidates for the therapy of lysosomal storage disorders. Novel stereoselective syntheses of NOV 1 and NOEV 2 starting from naturally abundant (-)-shikimic acid are described in this article. The common key intermediate compound 5 was first synthesized from readily available (-)-shikimic acid 9 steps in 50% yield.

Activation of β-adrenergic receptor promotes cellular proliferation in human glioblastoma.

Glioblastoma multiforme is the most common and aggressive form of primary malignant brain tumor. Previous evidence demonstrates that β-adrenergic receptors (β-ARs) are closely associated with the occurrence and development of brain tumors. However, the functional role of β-ARs in human glioblastoma and the underlying mechanisms are not fully understood.