Injectable hydrogel made from antler mesenchyme matrix for regenerative wound healing creating a fetal-like niche.

Background: Scar formation and loss of cutaneous appendages are the greatest challenges in cutaneous wound healing. Previous studies have indicated that antler reserve mesenchyme (RM) cells and their conditioned medium improved regenerative wound healing with partial recovery of cutaneous appendages.

Aim: To develop hydrogels from the antler RM matrix (HARM) and evaluate the effect on wound healing.

The ctDNA-based postoperative molecular residual disease status in different subtypes of early-stage breast cancer.

Background: Breast cancer is a highly heterogeneous disease. Early-stage, non-metastatic breast cancer is considered curable after definitive treatment. Early detection of tumor recurrence and metastasis through sensitive biomarkers is helpful for guiding clinical decision-making and early intervention in second-line treatment, which could improve patient prognosis and survival.

Chemical constituents of (Kom.) Nakai and their cytotoxic activities.

A new diarylheptanoid, (1 ,2,3,5)-2,3-dihydroxy-3',3''-dimethoxy-4'-de--methylcentrolobine () and a new bisabolane-type sesquiterpenoid, (1 ,7)-1,12,13-trihydroxybisabola-3,10-diene (), together with nineteen known compounds (-) were isolated from the EtOH extract of the stems and branches of (Kom.) Nakai. Their structures were elucidated by extensive analysis of 1 D and 2 D NMR spectra and from the HRESIMS.

Regorafenib suppresses colon tumorigenesis and the generation of drug resistant cancer stem-like cells via modulation of miR-34a associated signaling.

Background: Colorectal cancer (CRC) is one of the most prevalent malignancies in the world and developed drug resistance has represented one of the most challenging tasks for management. The current therapeutic regimens may select and enrich cancer stem-like cells (CSCs) resulting in the increased resistance against treatment, metastatic potential and mortality. Regorafenib is a multi-kinase inhibitor, an FDA-approved last-of-line treatment for patients with chemo-refractory metastatic CRC.

Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine.

Trichostatin A (TSA) possess histone deacetylase (HDAC) inhibitory potential, can reverse the deactivation of tumor suppressor genes and inhibit tumor cell proliferation. We evaluated the effect of TSA on HDAC expression, tumor cell proliferation, and cancer stem cells (CSCs) activities in pancreatic ductal adenocarnoma (PDAC) cells. The PDAC cell lines MiaPaCa-2 and PANC-1 were distinctly sensitive to TSA, with enhanced apoptosis, compared to SAHA.

Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity.

Six previously undescribed diterpenoids, named euphorantins S-T and euphorneroids A-D, including ingol and ent-atisane types, along with eleven known diterpenoids, were isolated from Euphorbia neriifolia. Their structures were elucidated on the basis of extensive NMR analysis and high resolution mass spectrometry. Euphorneroid D and ent-3-oxoatisan-16α,17-acetonide exhibited moderate anti-HIV-1 activities, with EC values of 34 μM (SI = 2.

Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata.

Three new compounds ( - ), including a sesterterpenoid, aspterpenacid C (), with an unusual 5/3/7/6/5 pentacyclic skeleton, together with seven known ones ( - ), were isolated from the ethanol extract of the traditional Chinese medicinal plant Their structures were elucidated on the basis of the methods of spectroscopic NMR, MS, and computational chemistry. The structure of was further confirmed by single-crystal X-ray diffraction analysis. Compounds  -  were tested for activities on the inhibition of nitric oxide production and HIV-1 replication .

[Purification function and ecological services value of Crassostrea sp. in Yangtze River estuary].

Oyster reef ecosystem is a natural decontamination plant of estuarine environment. This paper analyzed the bioaccumulation of heavy metals by Crassostrea sp. population at the dams of Yangtze River estuary, with its purification capacity and ecological services value assessed.