Reconstruction and analysis of potential biomarkers for hypertrophic cardiomyopathy based on a competing endogenous RNA network.

Hypertrophic cardiomyopathy (HCM) is a common heritable cardiomyopath. Although considerable effort has been made to understand the pathogenesis of HCM, the mechanism of how long noncoding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) network result in HCM remains unknown. In this study, we acquired a total of 520 different expression profiles of lncRNAs (DElncRNAs) and 371 messenger RNAs (mRNA, DEGs) by microarray and 33 microRNAs (DEmiRNAs) by sequencing in plasma of patients with HCM and healthy controls.

Gender differences of the improvement in balance control based on the real-time visual feedback system with smart wearable devices.

Purpose: The body maintains stability by integrating inputs from the central nervous system of vision, hearing, proprioception, and multiple senses. With the development of smart wearable devices, smart wearable devices can provide real-time center of pressure position-assisted balance control, which is beneficial to maintain physical balance.

Methods: Forty healthy college students (20 male, 20 female) participated in this study, and the posture balance actions of left-leg stance non-visual feedback, left-leg stance visual feedback, right-leg stance non-visual feedback, and right-leg stance visual feedback were performed.

[Analysis of allele dropout at TH01 locus in paternity testing].

Objective: To analyze allele dropout at TH01 locus in paternity testing in order to determine the accurate genotype.

Methods: To use a two STR loci genotyping system to verify an abnormal genotype for the TH01 locus with PCR using specific primers, cloning and DNA sequencing.

Results: A rare allele at TH01 locus named 5.