Publications by authors named "Shi-Jia Huang"
Augmented CD4 T cell response in autoimmunity is characterized by extensive metabolic reprogramming. However, the epigenetic molecule that drives the metabolic adaptation of CD4 T cells remains largely unknown. Here, we show that lysine acetyltransferase 6A (KAT6A), an epigenetic modulator that is clinically associated with autoimmunity, orchestrates the metabolic reprogramming of glucose in CD4 T cells.
View Article and Find Full Text PDFThe microbiota plays an important role in both hypertension (HTN) and periodontitis (PD), and PD exacerbates the development of HTN by oral and gut microbiota. Previous studies have focused on exploring the importance of the bacteriome in HTN and PD but overlooked the impact of the virome, which is also a member of the microbiota. We collected 180 samples of subgingival plaques, saliva, and feces from a cohort of healthy subjects (nHTNnPD), subjects with HTN (HTNnPD) or PD (PDnHTN), and subjects with both HTN and PD (HTNPD).
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated the causal link between certain cytokines and periodontitis using Mendelian randomization (MR) based on large-scale genetic data from genome-wide association studies (GWAS).
- - Using various MR methods, the research found that interleukin 9 (IL9) showed a positive causal link to periodontitis, while interleukin 17 (IL17) showed a negative link.
- - However, the bidirectional MR analysis indicated that periodontitis itself did not cause changes in cytokine levels, highlighting the complex relationship between these factors.
Mineralocorticoid receptor (MR) is a classic nuclear receptor and an effective drug target in the cardiovascular system. The function of MR in immune cells such as macrophages and T cells has been increasingly appreciated. The aim of this study was to investigate the function of Treg MR in the process of inflammatory bowel disease (IBD).
View Article and Find Full Text PDFContext: Thyroid hormones are associated with birth weight in singleton pregnancy. Twin pregnancies need more thyroid hormones to maintain the normal growth and development of the fetuses compared with single pregnancy.
Objective: We aimed to investigate the association of thyroid hormones and birth weight in twins.
Response of gut microbiota to serum metabolome changes in intrahepatic cholestasis of pregnant patients.
World J Gastroenterol
December 2020
Background: Intrahepatic cholestasis in pregnancy (ICP) is the most common liver disease during pregnancy, and its exact etiology and course of progression are still poorly understood.
Aim: To investigate the link between the gut microbiota and serum metabolome in ICP patients.
Methods: In this study, a total of 30 patients were recruited, including 15 patients with ICP (disease group) and 15 healthy pregnant patients (healthy group).
Introduction: The association between obesity before pregnancy and preterm birth varies with age and ethnicity.
Objective: To study the association between early body mass index (BMI) and risk of preterm birth in Chinese women.
Methods: This was a hospital-based retrospective cohort study including 36,596 Chinese women who gave birth to a live singleton infant from 2015 to 2018.