Publications by authors named "Shi-Hui Lei"

Article Synopsis
  • The study assessed the effects of Zuogui Jiangtang Jieyu Formula (ZJJ) on intestinal flora, short-chain fatty acids (SCFAs), and neuroinflammation in diabetic rats with depression.
  • Rats with a diabetes and depression model were divided into different treatment groups, including ZJJ low-dose and high-dose, and standard drugs (metformin + fluoxetine), with a blank group for comparison.
  • Results showed that ZJJ improved glucose metabolism, reduced depressive-like behaviors, decreased inflammatory markers in cerebrospinal fluid, and normalized intestinal flora and SCFA levels in the diabetic rats.
View Article and Find Full Text PDF

In the peripheral nervous system, the activation of Sirtuin 1 can improve insulin resistance; however, the role played by Sirtuin 1 in the central nervous system remains unknown. In this study, rat models of diabetes mellitus were generated by a single injection of streptozotocin. At 8 weeks after streptozotocin injection, the Morris water maze test and western blot assays confirmed that the diabetic model rats had learning and memory deficits, insulin resistance, and Sirtuin 1 expression could be detected in the hippocampus.

View Article and Find Full Text PDF