Publications by authors named "Shi-Hao Cui"
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation.
Acta Pharmacol Sin
December 2024
Article Synopsis
- Oligodendrocytes (OLs) are special cells in the brain that help protect nerves, but they can get damaged in diseases like multiple sclerosis.
- Researchers found that a certain pathway in the body called MEK/ERK stops the formation of these protective cells and makes it harder for the nerves to heal.
- They discovered that a medicine called Trametinib, which is used for cancer, can help create more OLs and improve healing of nerve damage in both mice and human cells.
The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation.
Acta Pharmacol Sin
March 2024
Oligodendrocytes (OLs) are glial cells that ensheath neuronal axons and form myelin in the central nervous system (CNS). OLs are differentiated from oligodendrocyte precursor cells (OPCs) during development and myelin repair, which is often insufficient in the latter case in demyelinating diseases such as multiple sclerosis (MS). Many factors have been reported to regulate OPC-to-OL differentiation, including a number of G protein-coupled receptors (GPCRs).
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