Publications by authors named "Shi-Hai Jiang"
Cell Signal
September 2021
Article Synopsis
- * Research shows that inhibiting a specific ISR factor, ATF4, can reduce harmful M1 polarization of microglia caused by inflammation, while using a small molecule ISR inhibitor, ISRIB, encourages a beneficial switch from M1 to M2 polarization.
- * ISRIB not only decreased harmful microglial activity but also improved behavioral outcomes in a rat model of surgical brain injury, suggesting ISR as a novel target for combating neuroinflammation post-injury.
